何冰芳 - 南京工业大学

个人简介

1978.10-1982.7中国药科大学（原“南京药学院”）药物化学（学士） 1982.7-1987.10中国药科大学生物化学教研室助教、讲师 1984.9-1987.6中国药科大学，生物药物学(硕士) 1987.10-1995.3日本筑波大学(University of Tsukuba, Japan)化学系，医学系外国人研究员 1995.4-1997.11中国药科大学生物制药学院讲师、副教授 1997.11-2001.3日本筑波大学(University of Tsukuba)应用生化系微生物（博士） 2001.9-2013.4南京工业大学制药与生命科学学院（09年~副院长）教授、2003年博士生导师 2013.4-至今，南京工业大学药学院党委书记、教授、博士生导师

研究领域

微生物学与生化制药、分子生物学、酶工程。主要从事生化制药，包括微生物菌种筛选, 非水相生物催化, 酶催化机理与调控, 生物制药高效酶类的设计与制备，高效生化药物合成等研究,；特别是极端微生物新功能及其新酶类的发现与开发，尤其是耐有机溶媒极端微生物及其工业用生物催化剂等发现与功能开发，并将其用于医药中间体的拆分与制备，活性小肽的制备，中草药有效成分改造

近期论文

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Yan Cao, Yu Zhuang, Changjin Yao, Bin Wu, Bingfang He*; Purification and characterization of an organic solvent-stable lipase from Pseudomonas stutzeri LC2-8 and its application for efficient resolution of (R, S)-1-phenylethanol. Biochemical Engineering Journal 2012, 64(15), 55–60 (IF 2.645) Lu Zheng, Zhong-zhong Bai, Ting-ting Xu, Bing-fang He*; Glucokinase contributes to glucose phosphorylation in D-lactic acid production by Sporolactobacillus inulinus Y2-8 J Ind Microbiol Biotechnol 2012, 39:1685–1692 (IF 2.735) Chenghua Wang, Ribo Huang, Bingfang He, Qishi Du*，Improving the thermostability of alpha-amylase by combinatorial coevolving-site saturation mutagenesis BMC Bioinformatics 2012, 13:263 Changjin Yao; Yan Cao; Shanshan Wu; Shuang Li; Bingfang He*, An organic solvent and thermally stable lipase from Burkholderia ambifaria YCJ01: purification, characteristics and application for chiral resolution of mandelic acid J. Molecular Catalysis B: Enzymatic 2013, 85-86， 105-110 (IF 2.735) Jiaxing Xu，Yu Zhuang，Bin Wu，Long Su，Bingfang He* Calcium ion-Induced Stabilization of the Protease from Bacillus cereus WQ9-2 in Aqueous Hydrophilic Solvents: Effect of Calcium Ion Binding on the Hydration Shell and Intramolecular Interactions J. Biological Inorganic Chemistry 2013, 18:211-221 (IF 3.289) Jiaxing Xu, Honglin Sun, Xuejun He, Zhongzhong Bai, Bingfang He*，Highly efficient synthesis of endomorphin-2 under thermodynamic control catalyzed by organic solvent stable proteases with in situ product removal Bioresource technology 2013 (129) 663–666 (IF 4.98) Sen Zhang, Zhi Zhou, Zhong Yao, Bingfang He*; Efficient production of skimmin and 6'-succinylskimmin from umbelliferone by organic solvent-tolerant Bacillus licheniformis ZSP01 using nitrogen sources regulation strategy. Biochemical Engineering Journal 2013 (71) 105–110 (IF 2.645) Xueming Wu, Jianlin Chu, Bin Wu，Sen Zhang，Bingfang He*；An Efficient Novel Glycosylation of Flavonoid by β-Fructosidase Resistant to Hydrophilic Organic Solvents. Bioresource technology 2013 (129) 659–662 (IF 4.98) Xueming Wu, Jianlin Chu, Jingyu Liang and Bingfang He*；Efficient enzymatic synthesis of mangiferin glycosides in hydrophilic organic solvents. RSC Advances (Royal Society of Chemistry Advances) 2013, 3, 19027–19032 (IF 2.562) Xueming Wu, Jianlin Chu, Tingting Xu, Bingfang He；Isolation, identification and pharmacokinetic analysis of fructosyl puerarins from enzymatic glycosylation. J of chromatography B, 2013; 935C:70-74. (IF2.78) Lu Zheng, Tingting Xu, Zhongzhong Bai, Bingfang He*; Mn2+/Mg2+-dependent pyruvate kinase from a D-lactic acid-producing bacterium Sporolactobacillus inulinus: characterization of a novel Mn2+-mediated allosterically regulated enzyme Applied Microbiology and Biotechnology 2014，98(4): 1583-1593 (IF 3.811) Jiaxing Xu, Zhi Zhou, Bin Wu, Long Su, Bingfang He* Enzymatic formation of a novel cell-adhesive hydrogel based on small peptides with laterally grafted L-3, 4-dihydroxyphenylalanine group, Nanoscale, 2014, 6, 1277–1280 (IF6.739) Jianlin Chu， Xueming Wu，Bo Li，Bingfang He*; Efﬁcient Glucosylation of Flavonoids by Organic Solvent-Tolerant Staphylococcus saprophyticus CQ16 in Aqueous Hydrophilic Media, J. Molecular Catalysis B: Enzymatic 2014, 99: 8-13 (IF 2.745) Yan Cao, Shanshan Wu, Jiahuang Li, Bin Wu, Bingfang He*； Highly efficient resolution of mandelic acid using lipase from Pseudomonas stutzeri LC2-8 and a molecular modeling approach to rationalize its enantioselectivity J. Molecular Catalysis B: Enzymatic 2014, 99:108-113 (IF 2.745) Jiaxing Xu, Bingfang He, Bin Wu, Bin Wang, Chenghua Wang, Lei Hu; An ionic liquid tolerant cellulase derived from chemically polluted microhabitats and its application in in situ saccharification of rice straw Bioresource Technology 2014, 157(1): 166–173. (IF: 5.039). Bin Wang, Wenhao Li, Bin Wu, Bingfang He*; Efﬁcient resolution of 3-phenoxy-1,2-propanediol by immobilized lipase on amphiphilic comb polymer modiﬁed TiO2. J. Molecular Catalysis B: Enzymatic 2014, 106: 105–110 (IF 2.745) Jianlin Chu, Xueming Wu, Bin Wu, Rui Wang, Bingfang He*; Characteristics of an organic solvent-tolerant β-fructofuranosidase from Arthrobacter arilaitensis NJEM01 with board substrate specificity and efficiently biosynthesize prebiotic kestose. J. Agricultural & Food Chemistry 2014 62(4): 5408-5411 (IF 3.107) Chenghua Wang, Qingyan Wang, Siming Liao, Bingfang He, Ribo Huang*; Thermal stability and activity improvements of a Ca-independentα-amylase fromBacillus subtilisCN7 by C-terminal truncation and hexahistidine-tag fusion。 Biotechnology and Applied Biochemistry 2014，2，99-100 (IF 1.322) Keke Liu, Fucheng Zhu, Ling Zhu, Guoguang Chen, Bingfang He*; Highly efficient enzymatic synthesis of Z-aspartame in aqueous medium via in situ product removal. Biochemical Engineering Journal 98 (2015) 63–67 Sen Zhang, Guoguang Chen, Jianlin Chu, Bin Wu, Bingfang He*; High production of succinyl isoflavone glycosides by Bacillus licheniformis ZSP01 resting cells in aqueous miscible organic medium. Biotechnology and Applied Biochemistry DOI: 10.1002/bab.1258 Jiaduo Sun, Lu Zheng, Bin Wu, Bingfang He*; Enhanced production rate of D-lactic acid by Sporolactobacillus sp.Y2-8 mutant generated by atmospheric and room temperature plasma. Biotechnology and Applied Biochemistry DOI: 10.1002/bab.1267