当前位置: X-MOL首页全球导师 海外导师 › Carreira, Erick M.
扫描左侧二维码
使用公众号菜单
手机上轻松查询100,000+导师

个人简介

Professor Carreira was born in Havana, Cuba in 1963. He obtained a B.S. degree in 1984 from the University of Illinois at Urbana-Champaign under the supervision of Scott E. Denmark and a Ph.D. degree in 1990 from Harvard University under the supervision of David A. Evans. After carrying out postdoctoral work with Peter Dervan at the California Institute of Technology through late 1992, he joined the faculty at the same institution as an assistant professor of chemistry and subsequently was promoted to the rank of associate professor of chemistry in the Spring of 1996, and full Professor in Spring 1997. He is the recipient of the American Chemical Society Award in Pure Chemistry, Nobel Laureate Signature Award, Fresenius Award, a David and Lucile Packard Foundation Fellowship in Science, Alfred P. Sloan Fellowship, Camille and Henry Dreyfus Teacher Scholar Award, Merck Young Investigator Award, Eli Lilly Young Investigator Award, Pfizer Research Award, National Science Foundation CAREER Award, Arnold and Mabel Beckman Young Investigator Award, and a Camille and Henry Dreyfus New Faculty Award. He is also the recipient of the Associated Students of the California Institute of Technology Annual Award in Teaching and a Richard M. Badger Award in Teaching.

研究领域

Organic Synthesis/Natural Products

Professor Carreira's research program focuses on the asymmetric synthesis of biologically active, stereochemically complex, natural products. Target molecules are selected which pose unique challenges in asymmetric bond construction. A complex multistep synthesis endeavor provides a goal-oriented setting within which to engage in reaction innovation and design. Drawing from the areas of organometallic chemistry, coordination chemistry, and molecular recognition, Carreira's group is developing catalytic and stoichiometric reagents for asymmetric stereocontrol.

近期论文

M. Brandstätter, M. Freis, N. Huwyler, E.M. Carreira, Angew. Chem. Int. Ed., Accepted Article. https://doi.org/10.1002/ange.201813090 Pyridyl Radical Cation for C–H Amination of Arenes S.L. Rössler, B.J. Jelier, P.F. Tripet, A. Shemet, G. Jeschke, A. Togni, E.M. Carreira, Angew. Chem. Int. Ed. 2019, 131, 536 –541.http://dx.doi.org/10.1002/ange.201810261 [1,3]‐Sigmatropic Shift of an Allylic Chloride J. Boshkow, T. Scattolin, F. Schoenebeck, E.M. Carreira, Helv. Chim. Acta. 2018, 101, e18001. https://doi.org/10.1002/hlca.201800148 Total Synthesis of (–)-Mitrephorone A M.J.R. Richter, M. Schneider, M. Brandstätter, S. Krautwald, E.M. Carreira, J. Am. Chem. Soc., 2018, 140, 16704–16710.http://dx.doi.org/10.1021/jacs.8b09685 Identification of biologically active δ-lactone eicosanoids as paraoxonase substrates J.F. Teiber, J. Xiao, G.L. Kramer, S. Ogawa, C. Ebner, H. Wolleb, E.M. Carreira, D.M. Shih, R.W. Haley, Biochem. Biophys. Res. 2018, 505, 87–92 https://doi.org/10.1016/j.bbrc.2018.09.083 Total Synthesis of Epicolactone A. G. Kravina, E.M. Carreira, Angew. Chem. Int. Ed. 2018, 57, 13159–13162 http://dx.doi.org/10.1002/anie.201807709 Unconventional Rose Odorants: Serendipitous Discovery and Unique Olfactory Properties of 2,2-Bis(prenyl)-3-oxobutyronitrile and Its Derivatives N. Hauser, P. Kraft, E.M. Carreira, Synthesis 2018, 50,4490–4500. http://dx.doi.org/10.1055/s-0037-1610199 Trimethyl Orthoacetate and Ethylene Glycol Mono-Vinyl Ether as Enolate Surrogates in Enantioselective Iridium-Catalyzed Allylation Y. Sempere, E.M. Carreira, Angew. Chem. Int. Ed., 2018, 57, 7654–7658. http://dx.doi.org/10.1002/anie.201803558 Synthesis and Structure–Activity Relationship Studies of Anti-Inflammatory Epoxyisoprostane Analogues H. Wolleb, S. Ogawa, M. Schneider, A. Shemet, J. Muri, M. Kopf, E.M. Carreira, Org. Lett., 2018, 20, 3014−3016. http://dx.doi.org/10.1021/acs.orglett.8b01042 HATRIC-based identification of receptors for orphan ligands N. Sobotzki, M.A. Schafroth, A. Rudnicka, A. Koetemann, F. Marty, S. Goetze, Y. Yamauchi, E.M Carreira, B. Wollscheid, Nat. Comm. 2018, 9, 1519. http://dx.doi.org/10.1038/s41467-018-03936-z Apoc Social: A Mobile Interactive and Social Learning Platform for Collaborative Solving of Advanced Problems in Organic Chemistry N. Sievertsen, E.M. Carreira, Chimia, 2018, 72, 43–47. https://doi.org/10.2533/chimia.2018.43 Allenylic Carbonates in Enantioselective Iridium-Catalyzed Alkylations D.A. Petrone, M. Isomura, I. Franzoni, S.L. Rössler, E.M. Carreira, J. Am. Chem. Soc. 2018, 140, 4697–4704. http://dx.doi.org/10.1021/jacs.8b01416 Natural Products Synthesis: A Personal Retrospective and Outlook E.M. Carreira, Isr. J. Chem. 2018, 58, 114–121.http://dx.doi.org/10.1002/ijch.201700127 Selective Photoaffinity Probe That Enables Assessment of Cannabinoid CB2 Receptor Expression and Ligand Engagement in Human Cells M. Soethoudt, S.C. Stolze, M.V. Westphal, L. van Stralen, A. Martella, E.J. van Rooden, W. Guba, Z.V. Varga, H. Deng, S.I. van Kasteren, U. Grether, A.P. IJzerman, P. Pacher, E.M. Carreira, H.S. Overkleeft, A. Ioan-Facsinay, L.H. Heitman, M. van der Stelt, J. Am. Chem. Soc., 2018, 140, 6067–6075.http://dx.doi.org/10.1021/jacs.7b11281 Total Synthesis of (+)-Sarcophytin L.J. Nannini, Suren J.Nemat, E.M. Carreira, Angew. Chem. Int. Ed., 2018, 130, 831–834.http://dx.doi.org/10.1002/anie.201711372 Synthesis of Photoswitchable Δ9-Tetrahydrocannabinol Derivatives Enables Optical Control of Cannabinoid Receptor 1 Signaling M.V. Westphal, M.A. Schafroth, R.C. Sarott, M.A. Imhof, C.P. Bold, P. Leippe, A. Dhopeshwarkar, J.M. Grandner, V. Katritch, K. Mackie, D. Trauner, E.M. Carreira, J.A. Frank, J. Am. Chem. Soc. 2017, 139, 18206–18212. http://dx.doi.org/10.1021/jacs.7b06456 Total Synthesis of (−)-Rhazinilam and Formal Synthesis of (+)-Eburenine and (+)-Aspidospermidine: Asymmetric Cu-Catalyzed Propargylic Substitution A. Shemet, E.M. Carreira, Org. Lett. 2017, 19, 5529-5532. http://dx.doi.org/10.1021/acs.orglett.7b02619 Total Synthesis and Stereochemical Assignment of (+)-Broussonetine H S.L. Rössler, B.S. Schreib, M. Ginterseder, J.Y. Hamilton, E.M. Carreira, Org. Lett. 2017, 19, 5533–5536.http://dx.doi.org/10.1021/acs.orglett.7b02620 Stereochemistry and biological activity of chlorinated lipids: a study of danicalipin A and selected diastereomers J. Boshkow, S. Fischer, A.M. Bailey, S. Wolfrum, E.M. Carreira, Chem. Sci. 2017, 8, 6904-6910.http://dx.doi.org/10.1039/C7SC03124F

down
wechat
bug