Gu, Zhen - University of California, Los Angeles

个人简介

Dr. Zhen Gu is a Full Professor in the Department of Bioengineering and Director of the NIH Biotechnology Training in Biomedical Sciences and Engineering Program at the University of California, Los Angeles (UCLA). Dr. Gu received his B.S. degree in Chemistry and M.S. degree in Polymer Chemistry and Physics from Nanjing University. In 2010, he obtained Ph.D. at UCLA, under the guidance of Dr. Yi Tang in the Department of Chemical and Biomolecular Engineering. He was a Postdoctoral Associate working with Dr. Robert Langer at MIT and Harvard Medical School during 2010 to 2012. Before he moved to UCLA in 2018, he had been appointed as a Jackson Family Distinguished Professor in the Joint Department of Biomedical Engineering at the University of North Carolina at Chapel Hill and North Carolina State University.Dr. Gu’s group studies controlled drug delivery, bio-inspired materials and nanobiotechnology, especially for cancer and diabetes treatment. He has published over 160 research papers and applied over 50 patents. He is a co-founder of five start-up companies. He serves as an Associate Editor for Nano Research and Focus Group Chair of Bioinspired and Biomimetic Drug Delivery (BBDD) in the Controlled Release Society (CRS). Dr. Gu is the recipient of the Sloan Research Fellowship (2016), Biomaterials Science Lectureship Award (2018), Young Investigator Award of CRS (2017), Alcoa Foundation Research Achievement Award (2017), Pathway Award of the American Diabetes Association (ADA, 2015) and Young Innovator Award in Cellular and Molecular Engineering of the Biomedical Engineering Society (BMES, 2015). MIT Technology Review listed him in 2015 as one of the global top innovators under the age of 35 (TR35). He was elected to the College of Fellows of the American Institute for Medical and Biological Engineering (AIMBE) in 2019. Education 2010 PHD University of California, Los Angeles (UCLA), USA 2006 MSN anjing University, China 2003 BS Nanjing University, China Professional Appointments 2018-present Professor University of California, Los Angeles, USA 2016-2018 Associate Professor University of North Carolina at Chapel Hill | North Carolina State University, USA 2012-2016 Assistant Professor University of North Carolina at Chapel Hill | North Carolina State University, USA 2010-2012 Postdoctoral Fellow MIT | Harvard Medical School, USA

研究领域

Key Words: Bioresponsive Materials/Formulations/Devices; Cell Therapy; Smart Insulin Delivery; Cancer Immunotherapy; Bioinspired and Biomimetic Design Featured Inventions: Bioresponsive Microneedle Patches (Smart Insulin Patch; Browning Patch; Melanin Patch; Blood Thinner Patch; Cell Patch); Platelet-Delivered Immunotherapy; Adipocytes-Mediated Drug Delivery; Sprayable Immunotherapeutic Gel; Liquid-Metal Nanomedicine; Elastic Drug Delivery; Cold Plasma-Mediated Immunotherapy; Photothermal-Enhanced CAR T Therapy Our research laboratory is interested in exploring strategies that apply stimuli-responsive systems for delivering therapeutics in dose-, spatial- and temporal-controlled fashions. By accumulating and integrating tools of biomolecular engineering, materials chemistry and micro/nano fabrication, we are adapting the concept of “artificial vesicles”, which are inspired by effective approaches found in natural particulates, from viruses to cells. Drug delivery through such vehicles can be specifically regulated by physiological signals, such as glucose, ATP and reactive oxygen species, the level or activity of which is often closely associated with many diseases, including diabetes and cancer. In particular, we are studying glucose-responsive synthetic formulations and devices for delivering insulin in a self-regulated manner, which mimics the function of pancreatic β-cells. We are also developing the “programmed” anticancer drug delivery systems that can respond upon the elements within tumor microenvironment or subcellular environment and sequentially release multiple drugs to their most active destinations. In addition to endogenous triggers, we are also interested in utilizing exogenous triggers, such as ultrasound and light to achieve spatiotemporal administration.

近期论文

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Jicheng Yu, Jinqiang Wang, Yuqi Zhang, Guojun Chen, Weiwei Mao, Yanqi Ye, Anna R. Kahkoska, John B. Buse, Robert Langer, and Zhen Gu*, “Glucose-responsive insulin patch for the regulation of blood glucose in mice and minipigs", Nature Biomedical Engineering, 4(499), 2020 Link. Watch Video Introduction: Youtube or Youku Guojun Chen+, Zhitong Chen+, Di Wen, Zejun Wang, Hongjun Li, Yi Zeng, Gianpietro Dotti, Richard Wirz*, and Zhen Gu*, “Transdermal cold atmospheric plasma-mediated immune checkpoint blockade therapy”, Proceedings of the National Academy of Sciences U.S.A. (PNAS), 7(3687), 2020. Link Quan Zhou+, Shiqun Shao+, Jinqiang Wang, Changhuo Xu, Jiajia Xiang, Ying Piao, Zhuxian Zhou, Qingsong Yu, Jianbin Tang, Xiangrui Liu, Zhihua Gan, Ran Mo, Zhen Gu*, and Youqing Shen*, “Enzyme-Activatable Polymer-Drug Conjugate Augments Tumour Penetration and Treatment Efficacy”, Nature Nanotechnology, 14(799), 2019. Link Di Wen, Jinqiang Wang, George Van Den Driessche, Qian Chen, Yuqi Zhang, Guojun Chen, Hongjun Li, Jennifer Soto, Ming Liu, Masao Ohashi, Zejun Wang, Peter Abdou, Quanyin Hu, Gianpietro Dotti, Song Li, Denis Fourches, and Zhen Gu*, “Adipocytes as Anticancer Drug Delivery Depot”, Matter, 5(1203), 2019. (Cover) Link Jinqiang Wang, Jicheng Yu, Yuqi Zhang, Anna R.Kahkoska, Zejun Wang, Jun Fang, Julian P. Whitelegge, Song Li, John B. Buse, and Zhen Gu*, “Glucose Transporter Inhibitor-Conjugated Insulin Mitigates Hypoglycemia”, Proceedings of the National Academy of Sciences U.S.A. (PNAS), 22(10744), 2019. Link Zhaowei Chen, Zejun Wang, and Zhen Gu*, “Bioinspired and Biomimetic Nanomedicines”, Accounts of Chemical Research, 5(1255), 2019. Link Qian Chen, Chao Wang, Xudong Zhang, Guojun Chen, Quanyin Hu, Hongjun Li, Jinqiang Wang, Di Wen, Yuqi Zhang, Yifei Lu, Guang Yang, Chen Jiang, Jun Wang, Gianpietro Dotti and Zhen Gu*, “In situ sprayed bioresponsive immunotherapeutic gel for post-surgical cancer treatment”, Nature Nanotechnology, 14(89), 2019. Link (View PDF) Also see: Nat. Nano’s highlights Quanyin Hu, Wujin Sun, Jinqiang Wang, Huitong Ruan, Xudong Zhang, Yanqi Ye, Song Shen, Chao Wang, Weiyue Lu, Ke Cheng, Gianpietro Dotti, Joshua F. Zeidner, Jun Wang, and Zhen Gu*, “Conjugation of Haematopoietic Stem Cells and Platelets Decorated with Anti-PD-1 Antibodies Augments Anti-leukaemia Efficacy”, Nature Biomedical Engineering, 2(831), 2018. Link (View PDF) also see: Nat. Biomed. Eng’s highlight (View PDF) Zhaowei Chen, Jinqiang Wang, Wujin Sun, Edikan Archibong, Anna R. Kahkoska, Xudong Zhang, Yue Lu, Frances S. Ligler, John B. Buse, Zhen Gu*, “Synthetic β-cells for Fusion-Mediated Dynamic Insulin Secretion”, Nature Chemical Biology, 14(86), 2018. Link also see: JAMA‘s highlight Chao Wang+, Jinqiang Wang+, Xudong Zhang, Shuangjiang Yu, Di Wen, Quanyin Hu, Yanqi Ye, Hunter Bomba, Xiuli Hu, Zhuang Liu, Gianpietro Dotti, Zhen Gu*, “In Situ Formed Reactive Oxygen Species-Responsive Scaffold with Gemcitabine and Checkpoint Inhibitor for Combination Therapy”, Science Translational Medicine, 10(eaan3682), 2018. Link also see: Nat. Rev. Cancer‘s highlight Jicheng Yu, Yuqi Zhang, Yanqi Ye, Rocco DiSanto, Wujin Sun, Davis Ranson, Frances Ligler, John Buse, Zhen Gu*, “Microneedle-Array Patches Loaded with Hypoxia-Sensitive Vesicles Provide Fast Glucose-Responsive Insulin Delivery”, Proceedings of the National Academy of Sciences U.S.A. (PNAS), 112(8260), 2015. Link also see: Nature‘s highlight Chao Wang, Wujin Sun, Yanqi Ye, Quanyin Hu, Hunter Bomba, Zhen Gu*, " In situ Activation of Platelets with Checkpoint Inhibitors for Post-Surgical Cancer Immunotherapy", Nature Biomedical Engineering, 0011, 2017. Link (View PDF) also see: Nat. Rev. Clin. Oncol‘s highlight (View PDF) Yue Lu, Alex Aimetti, Robert Langer*, Zhen Gu*, “Bioresponsive Materials”, Nature Reviews Materials, 2(16075), 2016 Link (View PDF) Naveed Bakh, Mabel Cortinas, Michael Weiss, Robert Langer, Daniel Anderson, Zhen Gu, Sanjoy Dutta, Michael Strano*, “Glucose-Responsive Insulin by Molecular and physical Design”, Nature Chemistry, 9(937), 2017. Link Jicheng Yu, Yuqi Zhang, Zhen Gu*, “Advances in Bioresponsive Closed-loop Drug Delivery Systems", International Journal of Pharmaceutics, 544(350), 2018. Link Wujin Sun, Wenyan Ji, Quanyin Hu, Zhen Gu*, “Leveraging Physiology for Precision Drug Delivery”, Physiological Reviews, 97(189), 2017. Link Yuqi Zhang, Jicheng Yu, Hunter Bomba, Yong Zhu, Zhen Gu*, “Mechanical Force-Triggered Drug Delivery”, Chemical Reviews, 116(19), 2016. Link Jicheng Yu, Yuqi Zhang, Anna R. Kahkoska, Zhen Gu*, “Bioresponsive Transcutaneous Patches", Current Opinion in Biotechnology, 48(28), 2017. Link Yue Lu, Quanyin Hu, Yiliang Lin, Dennis B. Pacardo, Chao Wang, Wujin Sun, Frances S. Ligler, Michael D. Dickey, Zhen Gu*, “Transformable Liquid-Metal Nanomedicine”, Nature Communications, 6(10066), 2015. Link Wujin Sun, Wenyan Ji, Jordan M. Hall, Quanyin Hu, Chao Wang, Chase L. Beisel, Zhen Gu*, “Self‐Assembled DNA Nanoclews for the Efficient Delivery of CRISPR–Cas9 for Genome Editing”, Angewandte Chemie International Edition, 127(12197), 2015. Link