个人简介

2009-present Vice-Chancellor, Oxford University Professor of Organic Chemistry, Oxford University. 2004-2008 Provost, Yale University Benjamin Silliman Professor of Chemistry, Yale University. 2003-2004 Deputy Provost for Science and Technology, Yale University. 1999-2003 Chair of the Department of Chemistry, Yale University. 1998-2009 Professor, Molecular Biophysics and Biochemistry, Yale University. 1997-2004 Irénée duPont Professor of Chemistry, Yale University. 1994-1997 Chair of the Department of Chemistry, University of Pittsburgh. 1992-1997 Full Professor, Department of Chemistry, University of Pittsburgh. 1988-1992 Associate Professor, Department of Chemistry, University of Pittsburgh. 1981-1988 Assistant Professor, Department of Chemistry, Princeton University. 1981 Postdoctoral Fellow, Université Louis Pasteur, Strasbourg. 1980 Ph.D., Cambridge University. 1976 MSc, University of British Columbia. 1974 BSc, Exeter University. Recent Honors 2011 International Izatt Christiansen Award in Macrocyclic Chemistry. 2010 Member of the American Academy of Arts and Sciences. 2004 Fellow of the Royal Society, elected May. Howard Lecturer, Sydney Chemical Society. 2003 Project of the Year, Medicines for Malaria Venture, Geneva. Frontiers in Chemistry Lecturer, Texas A&M. 2002 Bender Lecturer, Northwestern University. Raymond N. Castle Student Conference Lecturer, University of South Florida. Gustavson Lecturer, University of Denver. 2001 Iddles Lecturer, University of New Hampshire. MIKI Plenary Lecturer, University of Minnesota. 2000 Boehringer Ingelheim Distinguished Lecturer, Colorado State University. 1999 Karcher Lecturer, University of Oklahoma. Friedman Lecturer, Rutgers University, Newark. Mary E. Knapp Award Lecturer, Virginia Commonwealth University. Arthur C. Cope Scholar Award, American Chemical Society.

研究领域

Organic Chemistry

The principal research interest of the Hamilton group is in the field of molecular recognition and its application to problems in organic and biological chemistry. Approaches include: • Artificial Receptor Design • Catalyst Development • Enzyme Inhibition • Peptidomimetic Design • Proteomimetic Design • Disruption of Protein-Protein Interactions • Modulation of Signal Transduction

近期论文

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E. A. German, J. E. Ross, P. C. Knipe, M. F. Don, S. Thompson, A. D. Hamilton β-Strand mimetic foldamers rigidified through dipolar repulsion Angewandte Chemie International Edition 2015, 54, 2649-2652. DOI: 10.1002/anie.201410290 P. C. Knipe, S. Thompson, A. D. Hamilton Ion-Mediated Conformational Switches Chemical Science 2015, 6, 1630-1639. DOI: 10.1039/C4SC03525A M. K. P. Jayatunga, S. Thompson, and A. D. Hamilton alpha-Helix mimetics: Outwards and upwards Bioorganic & Medicinal Chemistry Letters 2014, 24, 717-724. DOI: 10.1016/j.bmcl.2013.12.003 H. Lingard, J. T. Han, A. L. Thompson, I. K. H. Leung, R. T. W. Scott, S. Thompson, and A. D. Hamilton Diphenylacetylene-Linked Peptide Strands Induce Bidirectional beta-Sheet Formation Angewandte Chemie International Edition 2014, 53, 3650-3653. DOI: 10.1002/anie.201309353 Front Cover: 10.1002/anie.201401099 I. M. Jones, P. C. Knipe, T. Michaelos, S. Thompson, A. D. Hamilton Redox-Dependent Conformational Switching of Diphenylacetylenes Molecules 2014, 8, 11316-11332. DOI: 10.3390/molecules190811316 P. C. Knipe, H. Lingard, I. M. Jones, S. Thompson, A. D. Hamilton A Lewis Acid-Mediated Conformational Switch Organic & Biomolecular Chemistry 2014, 12, 7937-7941. DOI: 10.1039/C4OB01556H P. C. Knipe, I. M. Jones, S. Thompson, A. D. Hamilton Remote Conformational Control of a Molecular Switch via Methylation and Deprotonation Organic & Biomolecular Chemistry 2014. DOI: 10.1039/C4OB01991A M. K. P. Jayatunga, S. Thompson, T. C. McKee, M. C. Chan, K. M. Reece, A. P. Hardy, R. Sekirnik, P. T. Seden, K. M. Cook, J. B. McMahon, W. D. Figg, C. J. Schofield, A. D. Hamilton Inhibition of the HIF1α-p300 interaction by quinone- and indandione-mediated ejection of structural Zn(II) Eur. J. Med. Chem. 2014. DOI: 10.1016/j.ejmech.2014.06.006 C. G. Cummings, and A. D. Hamilton. Expedient route to functionalized and water soluble 5-6-5 imidazole-phenyl-thiazole based alpha-helix mimetics Tetrahedron 2013, 69(5), 1663-1668. DOI: 10.1016/j.tet.2012.11.070 O. V. Kulikov, S. Thompson, H. Xu, C. D. Incarvito, R. T. W. Scott, I. Saraogi, L. Nevola, and A. D. Hamilton Design and Synthesis of Oligoamide-Based Double α-Helix Mimetics European Journal of Organic Chemistry 2013, 17, 3433-3445. DOI: 10.1002/ejoc.201300363 P. C. Simister, J. Luccarelli, S. Thompson, D. H. Appella, S. M. Feller, and A. D. Hamilton Novel Inhibitors of a Grb2 SH3C domain interaction identified by a virtual screen Bioorganic and Medicinal Chemistry 2013, 21(14), 4027-4033. DOI: 10.1016/j.bmc.2012.10.023 A. B. Wolk, E. Garand, I. M. Jones, A. D. Hamilton, and M. A. Johnson Quantifying intrinsic ion-driven conformational changes in diphenylacetylene supramolecular switches with cryogenic ion vibrational spectroscopy The Journal of Physical Chemistry A 2013, 117(29), 5962-5969. DOI: 10.1021/jp3111925 L. Nevola, J. M. Rodriguez, S. Thompson, and A. D. Hamilton Super-secondary structure peptidomimetics: design and synthesis of an α-α hairpin analogue Supramolecular Chemistry 2013, 25, 586-590. DOI: 10.1080/10610278.2013.817581 W. E. Martucci, J. M. Rodriguez, M. A. Vargo, M. Marr, A. D. Hamilton and K. S. Anderson Exploring novel strategies for AIDS protozoal pathogens: α-helix mimetics targeting a key allosteric protein-protein interaction in C. hominis thymidylate synthase-dihydrofolate reductase (TS-DHFR) MedChemComm 2013, 4, 1247-1256. DOI: 10.1039/C3MD00141E P. S. Ghosh, and A. D. Hamilton. Supramolecular dendrimers: convenient synthesis by programmed self-assembly and tunable thermoresponsivity Chemistry- A European Journal 2012, 18(8), 2361-2368. DOI: 10.1002/chem.201103051 O. V. Kulikov, and A. D. Hamilton Synthesis of the novel trimeric benzamides- potential inhibitors of protein-protein interactions RSC Advances 2012, 2(6), 2454-2461. DOI: 10.1039/c2ra01153k A. G. Jamieson, D. Russell, and A. D. Hamilton. A 1,3-phenyl-linked hydantoin oligomer scaffold as a beta-strand mimetic Chemical Communications 2012, 48(31), 3709-3711. DOI: 10.1039/c2cc30295k S. Thompson, and A. D. Hamilton. Amphiphilic α-helix mimetics based on a benzoylurea scaffold Organic & Biomolecular Chemistry 2012, Advanced Article. DOI: 10.1039/C2OB25273B L. K. Tsou, C. H. Chen, G. E. Dutschman, Y. C. Cheng, and A. D. Hamilton. Blocking HIV-1 entry by a gp120 surface binding inhibitor Bioorganic & Medicinal Chemistry Letters 2012, 22(9), 3358-3361. DOI: 10.1016/j.bmcl.2012.02.079 S. Thompson, R. Vallinayagam, M. J. Adler, R. T. W. Scott, and A. D. Hamilton. Double-sided alpha-helix mimetics Tetrahedron 2012, 68(23), 4501-4505. DOI: 10.1016/j.tet.2011.11.010