研究领域

Organic Chemistry

Research within the Davies group is concerned with investigations into a wide variety of topics including the development of new synthetic methodology, catalysis, mechanistic investigations, total synthesis and collaborative projects in medicinal chemistry. For example, this includes new applications for the conjugate addition of enantiopure lithium amides, development of kinetic resolution processes for the preparation of functionalised molecular building blocks, new methods for nucleophilic fluorination, methodology for the chemoselective functionalisation of unsaturated amines at the olefin (rather than the nitrogen atom), and application of these methodologies to the total synthesis of natural products of biological significance (including pyrrolidines, piperidines, tropanes, pyrrolizidines, and imino- and aminosugars).

近期论文

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(559). Conformational analysis of triphenylphosphine ligands in stereogenic monometallic complexes: tools for predicting the preferred configuration of the triphenylphosphine rotor Costello, J. F.; Davies, S. G.; Gould, E. T. F.; Thomson, J. E. Dalton Trans. 2015, 44, 5451 Diastereoselective conjugate additions to alkoxycarbene cations of the iron chiral auxiliary [(η5-C5H5)Fe(CO)(PPh3)=C(OMe)CH=CHR]+ Davies, S. G.; Easton, R. J. C.; McKenna, J. M; Polywka, M. E. C; Thomson, J. E. J. Organomet. Chem. 2015, DOI: 10.1016/j.jorganchem.2015.01.026 [View Journal Page] Stemistry: The Control of Stem Cells in Situ Using Chemistry Davies, S. G.; Kennewell, P. D.; Russell, A. J.; Seden, P. T.; Westwood, R.; Wynne, G. M. J. Med. Chem., 2015, DOI: 10.1021/jm500838d [View Journal Page] Pinacolatoboron fluoride (pinBF) is an efficient fluoride transfer agent for synthesis of benzylic fluorides Cresswell, A. J.; Davies, S. G.; Figuccia, A. L. A.; Fletcher, A. M.; Heijnen, D.; Lee, J. A.; Morris, M. J.; Kennett, A. M. R.; Roberts, P. M.; Thomson, J. E. Tetrahedron Lett. 2015, DOI: 10.1016/j.tetlet.2014.12.044 [View Journal Page] Concise total asymmetric syntheses of (–)-fagomine, two of its epimers, and two seven-membered ring congeners Csatayová, K.; Davies, S. G.; Fletcher, A. M.; Ford, J. G.; Klauber, D. J.; Roberts, P. M. Thomson, J. E.Tetrahedron 2015, DOI: 10.1016/j.tet.2014.12.004 [View Journal Page] Epoxidation of trans-4-aminocyclohex-2-en-1-ol derivatives: competition of hydroxyl-directed and ammonium-directed pathways Brennan, M. B.; Davies, S. G.; Fletcher, A. M.; Lee, J. A.; Roberts, P. M.; Russell, A. J.; Thomson, J. E. Aust. J. Chem. 2015, DOI: 10.1071/CH14531 [View Journal Page] Beyond the Balz-Schiemann reaction: the utility of tetrafluoroborates and boron trifluoride as nucleophilic fluoride sources Davies, S. G.; Roberts, P. M.; Cresswell, A. J.; Thomson, J. E. Chem. Rev. 2015, 115, 566 The homalium alkaloids: isolation, synthesis and absolute configuration assignment Davies, S. G.; Thomson J. E. In The Alkaloids: Chemistry and Biology; Knölker, H.-J., Ed.; Elsevier: London, U.K., 2015; Vol. 74, pp 121–158 [View Abstract] Selective electrochemical determination of cysteine with a cyclotricatechylene modified carbon electrode Lee, P. T.; Thomson, J. E.; Karina, A.; Salter, C.; Johnston, C.; Davies, S. G.; Compton, R. G. Analyst 2014, 140, 236 [View Journal Page] Asymmetric syntheses of (–)-3-epi-fagomine, (2R,3S,4R)-dihydroxypipecolic acid and several polyhydroxylated homopipecolic acids Csatayová, K.; Davies, S. G.; Fletcher, A. M.; Ford, J. G.; Klauber, D. J.; Roberts, P. M.; Thomson, J. E. J. Org. Chem. 2014, 79, 10932 [View Journal Page]