Bayley, Hagan - University of Oxford - Department of Chemistry

研究领域

Our laboratory uses the techniques of protein chemistry, molecular genetics and biophysics. Much of our work is centered on membrane proteins, in particular channels and pores. We investigate both the fundamental properties of these proteins and their applications in biotechnology.

近期论文

查看导师最新文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Pulcu, G.S., Mikhailova, E., Choi, L.-S. and Bayley, H. Continuous observation of the stochastic motion of an individual small-molecule walker. Nature Nanotechnology, published ASAP (2015) DOI: 10.1038/nnano.2014.264 Czekalska, M.A., Kaminski, T.S., Jakiela, S. K., Sapra, T., Bayley, H. and Garstecki, P. Automated microfluidic system for generation of lipid bilayers and screening of membrane protein activity. Lab on a Chip, published ASAP (2014) DOI: 10.1039/C4LC00985A Trick, J.L., Wallace, E.J., Bayley, H. and Sansom, M.S. Designing a hydrophobic barrier within biomimetic nanopores. ACS Nano, published ASAP (2014). DOI: 10.1021/nn503930p Rodriguez-Larrea, D. and Bayley, H. Protein co-translocational unfolding depends on the direction of pulling. Nature Communications 5, 4841 (2014). DOI: 10.1038/ncomms5841 Steffensen, M. B., Rotem, D. and Bayley, H. Single-molecule analysis of chirality in a multicomponent reaction network. Nature Chemistry, published ASAP (2014). DOI: 10.1038/nchem.1949 Stoddart, D., Ayub, M., Höfler, L., Raychaudhuri, P., Klingelhoefer, J.W., Maglia, G., Heron, A. and Bayley, H. Functional truncated membrane pores. Proc. Natl. Acad. Sci. USA 111, 2425-2430 (2014). DOI: 10.1073/pnas.131297611 Rosen, C. B., Rodriguez-Larrea, D. and Bayley, H. Single-molecule site-specific detection of protein phosphorylation. Nature Biotechnology, (2014). DOI: 10.1038/NBT.2799 Clamer, M., Hofler, L., Mikhailova, E., Viero, G. and Bayley, H. Detection of 3’-end RNA uridylation with a protein nanopore. ACS Nano, (2014). DOI: 10.1021/nn4050479 Wauer, T., Gerlach, H., Mantri, S., Hill, J., Bayley, H. and Sapra, K.T. Construction and manipulation of functional 3D droplet networks. ACS Nano, (2014). DOI: 10.1021/nn405433y Top | 2013 Ayub, M., Hardwick, S., Luisi, B. and Bayley, H. Nanopore-based identification of individual nucleotides for direct RNA sequencing. Nano Letters, (2013). DOI: 10.1021/nl403469r Harrington, L., Cheley, S. Alexander, L.T., Knapp, S. and Bayley, H. Stochastic detection of Pim kinases reveals electrostatically enhanced association of a peptide substrate. Proc. Natl. Acad. Sci. USA, in press (2013). DOI: 10.1073/pnas.1312739110 Reeve, J.E., Corbett, A.D., Boczarow, I., Kaluza, W., Barford, W., Bayley, H., Wilson, T. and Anderson, H.L. Porphyrins for probing electrical potential across lipid bilayer membranes by second harmonic generation. Angew. Chem. Int. Ed. 52, 9044-9048 (2013). DOI: 10.1002/anie.201304515 Kong, L. Li, Q., Harrington, L., Cheley, S., Davis, B. G. and Bayley, H. An extracellular inhibitor of the pore component of E. coli K30 polysaccharide transport. Nature Chemistry 5 651-659 (2013). DOI: 10.1038/nchem.1695 Choi, L.-S., Mach, T. and Bayley, H. Rates and stoichiometries of metal ion probes of cysteine residues within ion channels. Biophysical Journal 105, 356-364 (2013). DOI: 10.1016/j.bpj.2013.04.046 Housden, N.G., Hopper, J.T.S., Lukoyanova, N., Rodriguez-Larrea, D., Wojdyla, J.A., Klein, A., Kaminska, R., Bayley, H., Saibil, H.R., Robinson, C.V. and Kleanthous, C. Intrinsically disordered protein threads through the bacterial outer membrane porin OmpF. Science 340, 1570-1574 (2013). DOI: 10.1126/science.1237864 Cracknell, J.A., Japrung, D. and Bayley, H. Translocating kilobase RNA through the staphylococcal α-hemolysin nanopore. Nano Letters 13, 2500-2505 (2013). DOI: 10.1021/nl400560r Mantri, S., Sapra, K.T., Cheley, S., Sharp, T. and Bayley, H. An engineered dimeric protein pore that spans adjacent lipid bilayers. Nature Communications 4, 1725 (2013). DOI: 10.1038/ncomms2726 Li, W.-W., Gong, L. and Bayley, H. Single-molecule detection of 5-hydroxymethylcytosine in DNA through chemical modification and nanopore analysis. Angew. Chem. Int. Ed. 52, 4350-4355 (2013). DOI: 10.1002/anie.201300413 Villar, G., Graham, A.D. and Bayley, H. A tissue-like printed material. Science 340, 48-52 (2013). DOI: 10.1126/science.1229495 Rodriguez-Larrea, D. and Bayley, H. Multistep protein unfolding during nanopore translocation. Nature Nanotechnology 8, 288-295 (2013). DOI: 10.1038/nnano.2013.22 Top | 2012 Sapra, K.T. and Bayley, H. Lipid-coated hydrogel shapes as components of electrical circuits and mechanical devices. Scientific Reports 2, 848 (2012). DOI: 10.1038/srep00848 Ayub, M. and Bayley, H. Individual RNA base recognition in immobilized oligonucleotides using a protein nanopore. Nano Letters 12, 5637-5643 (2012). DOI: 10.1021/nl3027873 Syeda, R., Santos, J.S., Montal, M. and Bayley, H. Tetrameric assembly of KvLm K+ channels with defined numbers of voltage-sensors. Proc. Natl. Acad. Sci. USA 109, 16917-16922 (2012). DOI: 10.1073/pnas.1205592109 Boersma, A. and Bayley, H. Continuous stochastic detection of amino acid enantiomers with a protein nanopore. Angew. Chem. Int. Ed. 51, 9606-9609 (2012). DOI: 10.1002/anie.201205687 Reeve, J.E., Corbett, A.D., Boczarow, I., Wilson, T, Bayley, H and Anderson, H.L. Probing the orientational distribution of dyes in membranes through multiphoton microscopy. Biophysical Journal 103, 907-917 (2012). DOI: 10.1016/j.bpj.2012.08.003 Soskine, M., Biesemans, A., Moeyaert, B., Cheley, S., Bayley, H. and Maglia, G. An engineered ClyA nanopore detects folded target proteins by selective binding and translocation. Nano Letters 12, 4895-4900 (2012). DOI: 10.1021/nl3024438 Choi, L.-S. and Bayley, H. S-Nitrosothiol chemistry at the single-molecule level. Angew. Chem. Int. Ed. 51, 7972-7976 (2012). DOI: 10.1002/anie.201202365 Boersma, A., Brain, K. and Bayley, H. Real-time stochastic detection of multiple neurotransmitters with a protein nanopore. ACS Nano 6, 5304-5308 (2012). DOI: 10.1021/nn301125y Rotem, D., Jayasinghe, K., Salichou, M. and Bayley, H. Protein detection by nanopores equipped with aptamers. J. Am. Chem. Soc. 134, 2781-2787 (2012). DOI: 10.1021/ja2105653