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个人简介

学习经历 2001/9 - 2005/6,山东大学,制药工程,学士 2005/9 - 2008/6,山东大学,药物化学,硕士,导师:刘新泳 2008/9 - 2010/6,山东大学,药物化学,博士,导师:刘新泳 工作经历 2010/7 - 2012/11,山东大学,药学院药物化学研究所,讲师 2010/7 - 2012/07,山东大学,医学院病原生物学研究所,博士后 2012/11 - 2014/11,日本学术振兴会外国人特别研究员,国家留学基金委公派访问学者 2014/11 - 2020.12,山东大学,药学院药物化学研究所,副教授,硕士生导师 2021.01 - 今,山东大学,药学院药物化学研究所,教授,博士生导师

研究领域

1. 基于合理药物设计与表型筛选的抗病毒创新药物研究(艾滋病、乙肝、流感、冠状病毒感染等) 2. 基于药效团及作用机制的抗痛风创新药物研究 3. 类药性化合物库构建与高效筛选方法研究

近期论文

查看导师最新文章 (温馨提示:请注意重名现象,建议点开原文通过作者单位确认)

Ma Y, Frutos-Beltrán E, Kang D, Pannecouque C, De Clercq E*, Menéndez-Arias L*, Liu X*, Zhan P*. Medicinal chemistry strategies for discovering antivirals effective against drug-resistant viruses. Chem Soc Rev. 2021;50(7):4514-4540. Sun L, Dick A, Meuser ME, Huang T, Zalloum WA, Chen CH, Cherukupalli S, Xu S, Ding X, Gao P, Kang D, De Clercq E, Pannecouque C, Cocklin S*, Lee KH*, Liu X*, Zhan P*. Design, Synthesis, and Mechanism Study of Benzenesulfonamide-Containing Phenylalanine Derivatives as Novel HIV-1 Capsid Inhibitors with Improved Antiviral Activities. J Med Chem. 2020;63(9):4790-4810. Zhao T, Meng Q, Sun Z, Chen Y, Ai W, Zhao Z, Kang D, Dong Y, Liang R, Wu T, Pang J*, Liu X*, Zhan P*. Novel Human Urate Transporter 1 Inhibitors as Hypouricemic Drug Candidates with Favorable Druggability. J Med Chem. 2020;63(19):10829-10854. Kang D, Feng D, Sun Y, Fang Z, Wei F, De Clercq E, Pannecouque C*, Liu X*, Zhan P*. Structure-Based Bioisosterism Yields HIV-1 NNRTIs with Improved Drug-Resistance Profiles and Favorable Pharmacokinetic Properties. J Med Chem. 2020; 63(9):4837-4848. Kang D, Ruiz FX, Feng D, Pilch A, Zhao T, Wei F, Wang Z, Sun Y, Fang Z, De Clercq E, Pannecouque C, Arnold E*, Liu X*, Zhan P*. Discovery and Characterization of Fluorine-Substituted Diarylpyrimidine Derivatives as Novel HIV-1 NNRTIs with Highly Improved Resistance Profiles and Low Activity for the hERG Ion Channel. J Med Chem. 2020;63(3):1298-1312. Wu G, Zhao T, Kang D, Zhang J, Song Y, Namasivayam V, Kongsted J, Pannecouque C, De Clercq E, Poongavanam V*, Liu X*, Zhan P*. Overview of Recent Strategic Advances in Medicinal Chemistry. J Med Chem. 2019;62(21):9375-9414. Huang B, Chen W, Zhao T, Li Z, Jiang X, Ginex T, Vílchez D, Luque FJ, Kang D, Gao P, Zhang J, Tian Y, Daelemans D, De Clercq E, Pannecouque C*, Zhan P*, Liu X*. Exploiting the Tolerant Region I of the Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI) Binding Pocket: Discovery of Potent Diarylpyrimidine-Typed HIV-1 NNRTIs against Wild-Type and E138K Mutant Virus with Significantly Improved Water Solubility and Favorable Safety Profiles. J Med Chem. 2019;62(4):2083-2098. Kang D, Zhang H, Wang Z, Zhao T, Ginex T, Luque FJ, Yang Y, Wu G, Feng D, Wei F, Zhang J, De Clercq E, Pannecouque C, Chen CH, Lee KH, Murugan NA, Steitz TA, Zhan P*, Liu X*. Identification of Dihydrofuro[3,4- d]pyrimidine Derivatives as Novel HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors with Promising Antiviral Activities and Desirable Physicochemical Properties. J Med Chem. 2019;62(3):1484-1501. Zhang J, Murugan NA, Tian Y, Bertagnin C, Fang Z, Kang D, Kong X, Jia H, Sun Z, Jia R, Gao P, Poongavanam V, Loregian A, Xu W, Ma X, Ding X, Huang B*, Zhan P*, Liu X*. Structure-Based Optimization of N-Substituted Oseltamivir Derivatives as Potent Anti-Influenza A Virus Agents with Significantly Improved Potency against Oseltamivir-Resistant N1-H274Y Variant. J Med Chem. 2018;61(22):9976-9999. Zhang J, Poongavanam V, Kang D, Bertagnin C, Lu H, Kong X, Ju H, Lu X, Gao P, Tian Y, Jia H, Desta S, Ding X, Sun L, Fang Z, Huang B, Liang X, Jia R, Ma X, Xu W, Murugan NA, Loregian A, Huang B*, Zhan P*, Liu X*. Optimization of N-Substituted Oseltamivir Derivatives as Potent Inhibitors of Group-1 and -2 Influenza A Neuraminidases, Including a Drug-Resistant Variant. J Med Chem. 2018;61(14):6379-6397.

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