夏宁邵 - 厦门大学 - 生命科学学院

个人简介

1995-2002年，厦门大学生命科学学院，副教授； 2002年至今，厦门大学生命科学学院，教授、博导； 2005年至今，国家传染病诊断试剂与疫苗工程技术研究中心主任； 2011-2021年，厦门大学公共卫生学院，院长。

研究领域

从事传染病防控的基础研究、应用基础研究、转化医学研究，诊断试剂、疫苗、抗体研发，涉及病毒性肝炎、艾滋病、流感、手足口病、结核、人乳头瘤病毒相关疾病等。主持研制出全球首个戊肝疫苗、首个国产宫颈癌疫苗、新一代国际“金标准”戊肝诊断试剂、全球首个乙肝核心抗体定量试剂、全球首个艾滋尿液自检试剂；第二代九价宫颈癌疫苗进入III期临床试验、新型水痘减毒活疫苗（敲除毒力基因ORF7）进入II期临床试验，鼻喷流感病毒载体新冠肺炎疫苗已完成II期临床试验，正在菲律宾等国开展海外III期临床试验；向全球疫苗巨头葛兰素史克、赛诺菲巴斯德授权新一代宫颈癌疫苗和新型轮状病毒疫苗专利技术。

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1. Xu LF#, Zheng QB#, Zhu R#, Yin ZC#, Yu H#, Lin Y, Wu YY, He MZ, Huang Y, Jiang YC, Sun H, Zha ZH, Yang HW, Huang QZ, Zhang DQ, Chen ZQ, Ye XZ, Han JL, Yang LS, Liu C, Que YQ, Fang MJ, Gu Y, Zhang J, Luo W, Zhou ZH*, Li SW*, Cheng T*, Xia NS*. Cryo-EM structures reveal the molecular basis of receptor-initiated coxsackievirus uncoating. Cell Host & Microbe. 2021. (IF=15.923) 2. He MZ#, Xu LF#, Zheng QB#, Zhu R#, Yin ZC#, Zha ZH, Lin Y, Yang LS, Huang Y, Ye XZ, Li SX, Hou WH, Wu YT, Han JL, Liu DX, Li ZK, Chen ZQ, Yu H, Que YQ, Wang YB, Yan XD, Zhang J, Gu Y, Zhou ZH*, Cheng T*, Li SW*, Xia NS*. Identification of Antibodies with Non-overlapping Neutralization Sites that Target Coxsackievirus A16. Cell Host & Microbe. 2020;27(2):249-+. (IF=15.923) 3. Wang W#, Zheng QB#, Pan DQ#, Yu H#, Fu WK, Liu J, He MZ, Zhu R,Cai YZ,Huang Y,Zha ZH,Chen ZQ,Ye XZ,Han JL,Que YQ,Wu T,Zhang J,Li SW*,Zhu H*,Zhou ZH*,Cheng T*,Xia NS*.Near-atomic cryo-electron microscopy structures of varicella-zoster virus capsids. Nature Microbiology. 2020;10.1038/s41564-020-0785-y. (IF=15.54) 4. Wang DN#, Liu XL#, Wei MX#, Qian CY, Song S, Chen J, Wang ZP, Xu Q, Yang YR, He MZ, Chi X, Huang SW, Li TT, Kong ZB, Zheng QB, Yu H, Wang YB, Zhao QJ, Zhang J, Xia NS*, Gu Y*, Li SW*. Rational design of a multi-valent human papillomavirus vaccine by capsomere-hybrid co-assembly of virus-like particles. Nature Communications. 2020;11(1). （IF=12.121） 5. Wen GP#, He LL#, Tang ZM#, Wang SL#, Zhang X, Chen YZ, Lin XH, Liu C, Chen JX, Ying D, Chen ZH, Wang YB, Luo WX, Huang SJ, Li SW, Zhang J, Zheng ZZ*, Zhu J*, Xia NS*. Quantitative evaluation of protective antibody response induced by hepatitis E vaccine in humans. Nature Communications. 2020;11(1). （IF=12.121） 6. Zhang YL#, Wang SJ#, Wu YT#, Hou WH#, Yuan LZ#, Sheng CG#, Wang J, Ye JH, Zheng QB, Ma J, Xu JJ, Wei M, Li ZL, Nian S, Xiong HL, Zhang L, Shi Y, Fu BR, Cao JL, Yang CL, Li ZY, Yang T, Liu L, Yu H, Hu JD, Ge SX, Chen YX, Zhang TY, Zhang J, Cheng T*, Yuan Q*, Xia NS*. Virus-Free and Live-Cell Visualizing SARS-CoV-2 Cell Entry for Studies of Neutralizing Antibodies and Compound Inhibitors. Small Methods. （IF=12.13） 7. Zhang TY#, Chen HY#, Cao JL#, Xiong HL, Mo XB, Li TL, Kang XZ, Zhao JH, Yin B, Zhao X, Huang CH, Yuan Q*, Xue D*, Xia NS*, Yuan YA. Structural and functional analyses of hepatitis B virus X protein BH3-like domain and Bcl-xL interaction. Nature Communications. 2019;10(1):3192. (IF=11.878) 8. Liu X#, Liu C#, Zheng ZZ#, Chen SY, Pang X, Xiang XC, Tang JX, Ren E, Chen YZ, You M, Wang XY, Chen XY, Luo WX*, Liu G*, Xia NS*. Vesicular Antibodies: A Bioactive Multifunctional Combination Platform for Targeted Therapeutic Delivery and Cancer Immunotherapy. Adv Mater. 2019;31(17). (IF=25.809) 9. Yuan L#, Jiang J#, Liu X#, Zhang Y, Zhang L, Xin J, Wu K, Li X, Cao J, Guo X, Shi D, Li J, Jiang L, Sun S, Wang T, Hou W, Zhang T, Zhu H, Zhang J, Yuan Q, Cheng T*, Li J*, Xia N*. HBV infection-induced liver cirrhosis development in dual-humanised mice with human bone mesenchymal stem cell transplantation. Gut. 2019;68(11):2044-56.. (IF=17.943) 10. Zhang T-Y#, Guo X-R#, Wu Y-T#, Kang X-Z, Zheng Q-B, Qi R-Y, Chen B-B, Lan Y, Wei M, Wang S-J, Xiong H-L, Cao J-L, Zhang B-H, Qiao X-Y, Huang X-F, Wang Y-B, Fang M-J, Zhang Y-L, Cheng T, Chen Y-X, Zhao Q-J, Li S-W, Ge S-X, Chen P-J, Zhang J*, Yuan Q*, Xia N-S*. A unique B cell epitope-based particulate vaccine shows effective suppression of hepatitis B surface antigen in mice. Gut. 2020;69(2):343-54. (IF=17.943) 11. Qiao Y-L#*, Wu T#, Li R-C#, Hu Y-M#, Wei L-H#, Li C-G#, Chen W#, Huang S-J, Zhao F-H, Li M-Q, Pan Q-J, Zhang X, Li Q, Hong Y, Zhao C, Zhang W-H, Li Y-P, Chu K, Li M, Jiang Y-F, Li J, Zhao H, Lin Z-J, Cui X-L, Liu W-Y, Li C-H, Guo D-P, Ke L-D, Wu X, Tang J, Gao G-Q, Li B-Y, Zhao B, Zheng F-X, Dai C-H, Guo M, Zhao J, Su Y-Y, Wang J-Z, Zhu F-C, Li S-W, Pan H-R, Li Y-M, Zhang J*, Xia N-S*. Efficacy, safety, and immunogenicity of an Escherichia coli-produced bivalent human papillomavirus vaccine: An interim analysis of a randomized clinical trial. J Natl Cancer Inst. 2020;112(2):145-53.（IF=10.211） 12. Zheng Q,# Jiang J#, He M#, Zheng Z#, Yu H, Li T, Xue W, Tang Z, Ying D, Li Z, Song S, Liu X, Wang K, Zhang Z, Wang D, Wang Y, Yan X, Zhao Q, Zhang J, Gu Y*, Li S*, Xia N*. Viral neutralization by antibody-imposed physical disruption. Proc Natl Acad Sci U S A. 2019；116 (52) :26933-26940. (IF=9.58)