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Yanjuan Huang, Zilin Guan, Xiuling Dai, Yifeng Shen, Qin Wei, Lingling Ren, Jingwen Jiang, Zhanghong Xiao, Yali Jiang, Di Liu, Zeqian Huang, Xiaoyu Xu, Yong Luo, Chunshun Zhao*. Engineered macrophages as near-infrared light activated drug vectors for chemo-photodynamic therapy of primary and bone metastatic breast cancer. Nat Commun. 2021; 12(1):4310. doi: 10.1038/s41467-021-24564-0.
Xiaoyu Xu, Zishan Zeng, Xin Ding, Ting Shan, Qiuxing Liu, Meixu Chen, Jie Chen, Meng Xia, Yuanfeng He, Zeqian Huang, Yanjuan Huang, Chunshun Zhao*. Reactive oxygen species-activatable self-amplifying Watson-Crick base pairing-inspired supramolecular nanoprodrug for tumor-specific therapy. Biomaterials, 2021; 227:121128. DOI: 10.1016/j.biomaterials.2021.121128
Congjun Xu,† Zhanghong Xiao,† Jing Wang, Hualu Lai, Tao Zhang, Zilin Guan, Meng Xia, Meixu Chen, Lingling Ren, Yuanfeng He, Yuqi Gao, and Chunshun Zhao*. Discovery of a Potent Glutathione Peroxidase 4 Inhibitor as a Selective Ferroptosis Inducer. J Med Chem. 2021, 64(18):13312-13326. doi: 10.1021/acs.jmedchem.1c00569.
Yifeng Shen, Congjun Xu, Jie Chen, Zilin Guan, Yanjuan Huang, Zishan Zeng, Xiaoyu Xu, Xiaomin Tan, Chunshun Zhao*. Phototriggered Self-Adaptive Functionalized MOC-Based Drug Delivery Platform Promises High Antitumor Efficacy. Adv Healthc Mater. 2021, 10(19):e2100676. doi: 10.1002/adhm.202100676.
Congjun Xu, Haolan Yang, Zhanghong Xiao, Tao Zhang, Zilin Guan, Jie Chen, Hualu Lai, Xiaoyu Xu, Yanjuan Huang, Zeqian Huang, Chunshun Zhao*. Reduction-responsive dehydroepiandrosterone prodrug nanoparticles loaded with camptothecin for cancer therapy by enhancing oxidation therapy and cell replication inhibition. Int J Pharm. 2021; 603:120671. doi: 10.1016/j.ijpharm.2021.120671.
Yanjuan Huang, Zhanghong Xiao, Zilin Guan, Yifeng Shen, Yali Jiang, Xiaoyu Xu, Zeqian Huang, Chunshun Zhao*. A light-triggered self-reinforced nanoagent for targeted chemophotodynamic therapy of breast cancer bone metastases via ER stress and mitochondria mediated apoptotic pathways. J. Control Release, 2020;319:119-134. https://doi.org/10.1016/j.jconrel.2019.12.043
Zeqian Huang, Yanjuan Huang, Meixu Chen, Jie Chen, Zishan Zeng, Xiaoyu Xu, Binyao Huang, Yong Luo, Zhanghong Xiao, Yaqing Ding, Chunshun Zhao*. Bone-targeted oxidative stress nanoamplifier for synergetic chemo/chemodynamic therapy of bone metastases through increasing generation and reducing elimination of ROS. Chem. Eng. J., 2020; 399:125667, https://doi.org/10.1016/j.cej.2020.125667
Xiaoyu Xu, Zishan Zeng, Jie Chen, Binyao Huang, Zilin Guan, Yanjuan Huang, Zeqian Huang, Chunshun Zhao*. Tumor-targeted supramolecular catalytic nanoreactor for synergistic chemo/chemodynamic therapy via oxidative stress amplification and cascaded Fenton reaction. Chem. Eng. J., 2020; 390:124628, https://doi.org/10.1016/j.cej.2020.124628
Yanjuan Huang#, Yali Jiang#, Zhanghong Xiao#, Yifeng Shen, Liangfeng Huang, Xiaoyu Xu, Gaofei Wei, Congjun Xu, Chunshun Zhao⁎ . Three birds with one stone: A ferric pyrophosphate based nanoagent for synergetic NIR-triggered photo/ chemodynamic therapy with glutathione depletion. Chem. Eng. J., 2020;380:122369.
Yanjuan Huang, Zhanghong Xiao, Zilin Guan, Zishan Zeng, Yifeng Shen, Xiaoyu Xu, Chunshun Zhao*. Bone-seeking nanoplatform co-delivering cisplatin and zoledronate for synergistic therapy of breast cancer bone metastasis and bone resorption. Acta Pharm Sin B, 2020;10(12):2384-2403. https://doi.org/10.1016/j.apsb.2020.06.006
Xiaoyu Xu#, Binyao Huang#, Zishan Zeng, Jie Chen, Zeqian Huang, Zilin Guan, Meixu Chen, Yanjuan Huang, Chunshun Zhao*. Broaden sources and reduce expenditure: Tumor-specific transformable oxidative stress nanoamplifier enabling economized photodynamic therapy for reinforced oxidation therapy. Theranostics, 2020; 10(23): 10513-10530. doi: 10.7150/thno.49731
Xiaoyu Xu, Zishan Zeng, Zeqian Huang, Yangwen Sun, Yanjuan Huang, Jie Chen, Junxian Ye, Haolan Yang, Chanzhen Yang, Chunshun Zhao⁎. Near-infrared light-triggered degradable hyaluronic acid hydrogel for ondemand drug release and combined chemo-photodynamic therapy. Carbohyd Polym, 2020; 229:115394.
Xiaoqi Sun, Di Liu, Xiaoyu Xu, Yifeng Shen, Yanjuan Huang, Zishan Zeng, Meng Xia, Chunshun Zhao*. NIR-triggered thermo-responsive biodegradable hydrogel with combination of photothermal and thermodynamic therapy for hypoxic tumor. Asian J Pharm Sci, 2020; 15(6): 713-727. https://doi.org/10.1016/j.ajps.2019.1007
Zeqian Huang#, Gaofei Wei#, Zishan Zeng, Yanjuan Huang, Liangfeng Huang, Yifeng Shen, Xiaoqi Sun, Congjun Xu, Chunshun Zhao*. Enhanced cancer therapy through synergetic photodynamic/immune checkpoint blockade mediated by a liposomal conjugate comprised of porphyrin and IDO inhibitor. Theranostics, 2019; 9(19):5542-5557.
Gaofei Wei, Liangfeng Huang, Yifeng Shen, Zeqian Huang, Xiaoyu Xu, and Chunshun Zhao*. Porphyrin-based porous organic frameworks as oxygen reservoirs to overcome tumor hypoxia for enhanced photodynamic therapy. Adv. Ther., 201900059.
Gaofei Wei#*, LiangfengHuang#, YaliJiang#, YifengShen, ZeqianHuang, YanjuanHuang, XiaoqiSun, Chunshun Zhao*. Lenvatinib-zinc phthalocyanine conjugates as potential agents for enhancing synergistic therapy of multidrug-resistant cancer by glutathione depletion. Eur J Med Chem., 2019; 169:53-64.
Liangfeng Huang#, Gaofei Wei#,*, Xiaoqi Sun, Yali Jiang, Zeqian Huang, Yanjuan Huang, Yifeng Shen, Xiaoyu Xu, Yunhui Liao, Chunshun Zhao*. A tumor-targeted Ganetespib-zinc phthalocyanine conjugate for synergistic chemo-photodynamic therapy. Eur J Med Chem., 2018; 151: 294-303.
Xuefei Zhang, Binyao Huang, Yifeng Shen, Chanzhen Yang, Zeqian Huang, Yanjuan Huang, Xiaoyu Xu, Yali Jiang, Xiaoqi Sun, Xining Li, Mina Yan and Chunshun Zhao*. Near infrared light triggered reactive oxygen species responsive nanoparticles for chemo-photodynamic combined therapy. J. Mater. Chem. B, 2018; 6: 2347-2357.
Yuanfeng He1, Yanjuan Huang1, Ziyuan Huang, Yali Jiang, Xiaoqi Sun, Yifeng Shen, Weijing Chu, Chunshun Zhao*. Bisphosphonate-functionalized coordination polymer nanoparticles for the treatment of bone metastatic breast cancer. J Control Release. 2017; 264:76-88.
Xiaoyu Xu, Ziyuan Huang, Zeqian Huang, Xuefei Zhang, Siyu He, Xiaoqi Sun, Yifeng Shen, Mina Yan, Chunshun Zhao*. Injectable, NIR/pH-Responsive Nanocomposite Hydrogel as Long-Acting Implant for Chemo-Photothermal Synergistic Cancer Therapy. ACS Appl Mater Interfaces. 2017;9(24):20361-20375
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