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G蛋白偶联受体的功能研究;基于G蛋白偶联受体的中药新药发现

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Chi AP, Kang CZ, Zhang Y, Tang L, Guo HH, Li H, Zhang KR. (2015): Immunomodulating and antioxidant effects of polysaccharide conjugates from the fruits of Ziziphus Jujube on Chronic Fatigue Syndrome rats. Carbohydrate Polymers. 122: 189-196. Long Z, Zhang Y (Co-first author), Guo Z.M, Wang L.E, Xue X.Y, Zhang X.L, Wang S.S, Wang Z.W, Civelli O, Liang X.M.(2014): Amide alkaloids from Scopolia tangutica. Planta Medica, 80(13): 1124-1130. Zhang Y, Wang C.R, Guo Z.M, Zang X.L, Wang Z.W, Liang X.M, Civelli O. (2014): Discovery of N-methyltetrahydroprotoberberines with κ-opioid receptor agonists activities from corydalis yanhusuo W. T. Wang by using two-dimensional liquid chromatography. Journal of Ethnopharmacology, 155(3): 1597-1562. Zhang Y, Wang C.R, Wang L.E, Parks G.S, Zhang X.L, Guo Z.M, Ke Y.X, Li K.W, Kim M.K, Vo B, Borrelli E, Ge G.B, Yang L, Wang Z.W, Garcia-Fuster M.J, Luo Z.D, Liang X.M, Civelli O. (2014): A novel analgesic isolated from a Traditional Chinese medicine. Current Biology, 24 (2):117-123. Civelli O, Reinscheid R.K, Zhang Y, Wang Z.W, Fredriksson R, Schi?th H.B. (2013) : G protein-coupled receptor deorphanizations. Annual review of pharmacology and toxicology, 53:127-146. Zhang Y, Xu J.Y, Wang Z.W, Zhang X.L, Liang X.M, Civelli O. (2012): BmK-YA, an enkephalin-like peptide in scorpion venom. PLoS One, 7(7), e40417. Zhang Y, Wang Z.W, Cox D.P, Civelli O. (2012): Study on the activation of the opioid receptors by a set of morphine derivatives in a well-defined assay system. Neurochemical Research, 37(7), 410-416. Zhang Y, Wang Z.W, Parks G.S, Civelli O. (2011): Novel neuropeptides as ligands of orphan G protein-coupled receptors. Current Pharmaceutical Design, 17 (25), 2626-2631. Cai X.M, Zhang Y, Yu L, Guo Z.M, Zhang X.L, Liang X.M. (2011): Detection of drug-human serum albumin binding ratios of two Chinese medicinal ingredients by high performance affinity chromatography. Chinese Journal of Chromatography, 29(4):358-361. (In Chinese) Sun Y.G, Zhang X, Xue X.Y, Zhang Y, Xiao H.B, Liang X.M. (2009): Rapid identification of polyphenol C-glycosides from Swertia franchetiana by HPLC-ESI-MS-MS. Journal of Chromatographic Science, 47(3):190-196. Zhang C.N, Wang X.M, Zhang X.Z, Zhang Y, Xiao H.B, Liang X.M. (2009): Bioassay-guided separation of citreorosein and other oestrogenic compounds from Polygonum cuspidatum. Phytotherapy Research, 23(5):740-741. Zhang Y, Xue X.Y, Xu Q, Zhang F.F, Liang X. M. (2006): Development of the method of HPLC analysis of kudzu root crude extract, Chinese Journal of Chromatography , 24(04):354-358. (In English) Zhang C.N, Zhang X.Z, Zhang Y, Xu Q, Xiao H.B, Liang X.M. (2006): Analysis of estrogenic compounds in Polygonum cuspidatum by bioassay and high performance liquid chromatography. Journal of Ethnopharmacology, 105, 223-228. Zhang Y, Chen J.P, Zhang C.Z, Wu W.Z, Liang X.M. (2005): Analysis of the estrogenic components in kudzu root by bioassay and high performance liquid chromatography. The Journal of Steroid Biochemistry and Molecular Biology, 94, 375-381. Zhang Y, Xu Q, Zhang X.Z, Chen J.P, Liang X.M, Kettrup A. (2005): Identification of isoflavones and description of the biotransformation of kudzu root by high-performance liquid chromatography-tandem mass spectrometry. Analytical & Bioanalytical Chemistry, 383 (5), 787-796. Zhang Y, Zhang C.Z, Liang X.M. (2005): Determination of the estrogenic activity of enzyme-hydrolyzed kudzu root isoflavones by recombinant yeast. Chinese Journal of Food And Fermentation Industries, 2005, 31: 30-33. (In Chinese) Zhang Y, Zhang C.Z, Liang X.M. (2005): Study of the enzyme hydrolysis of kudzu root isoflavones, Chinese Journal of Fine Chemicals, 5, 354-356. (In Chinese) Zhang Y, Xu Q, Liang X.M. (2005): Construction of Multi-Components library of kudzu root, Chinese Journal of World Science and Technology Modernization of Traditional Chinese Medicine and Material Medic, 7(6), 62-66. (In Chinese) Zhang C.Z, Wang S.X, Zhang Y, Chen J.P, Liang X.M. (2005): In vitro estrogenic activities of Chinese medicinal plants traditionally used for the management of menopausal symptoms. Journal of Ethnopharmacology, 98, 295-300.

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