个人简介
教育背景:
1997 年 6 月,武汉大学化学系,理学学士
2000 年 5 月 - 2001 年 5 月,日本大阪大学,从事高分子溶液理论研究
2002 年 6 月,武汉大学化学与分子科学学院,理学博士
工作经历:
2001 年 7 月 - 2008 年 10 月,武汉大学化学与分子科学学院,从事高分子教学和科研
2008 年 10 月 - 2010 年 10 月,日本神户大学,从事多糖的结构 - 活性相关性研究
2010 年 10 月 - 至今,武汉大学化学与分子科学学院,从事高分子教学和科研
获奖荣誉:
2012 年入选武汉市 “黄鹤英才计划”;2013 年入选 “教育部新世纪优秀人才计划”;2015 年获聘武汉大学珞珈特聘教授;2022 年获聘武汉大学 - 中南医院交叉研究院特聘教授;2005 年湖北省自然科学一等奖(排名第 2);教育部 2012 年度 “高等学校十大科技进展”(排名第 3);担任 Bioactive Carbohydrates and Dietary Fibre 期刊编委 (2015 - 现在)
研究领域
多糖的多尺度结构、溶液性质及品质功能
多糖基微纳米材料
多糖的生物活性、构效关系及作用机制
近期论文
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1. Liqin Cai†, Shujun Zhou†, Xiaojuan Xu*, Yanfeng Wang*, Zongwei Cai*, Lina Zhang. The composites of triple-helix glucan nanotubes/selenium nanoparticles target hepatocellular carcinoma to enhance ferroptosis by depleting glutathione and augmenting redox imbalance. Chem. Eng. J. 2022, 446(3): 137110.
2. Liqin Cai, Lina Zhang, Xiaojuan Xu*. One-step synthesis of ultra-small silver nanoparticles-loaded triple-helix β-glucan nanocomposite for highly catalytic hydrogenation of 4-nitrophenol and dyes. Chem. Eng. J. 2022, 442(1): 136114.
3. Huanhuan Chen#, Ying Sun#, Xiaojuan Xu*, Qifa Ye*. Targeted delivery of methotrexate by modified yeast β-glucan nanoparticles for rheumatoid arthritis therapy. Carbohydr. Polym. 2022, 284: 119183.
4. Bingchao Duan, Ying Sun, Siwei Zou, Xiaojuan Xu*. Fabrication of tumor-targeting composites based on the triple helical a-glucan through conjugation of aptamer. Carbohydr. Polym. 2021, 254: 117476.
5. Ying Sun, Bingchao Duan, Huanhuan Chen, Xiaojuan Xu*. A novel strategy for treating inflammatory bowel disease by targeting delivery of methotrexate through glucan particles. Adv. Healthcare Mater. 2020, 9 (6): 1901805.
6. Siwei Zou, Bingchao Duan, Xiaojuan Xu*. Inhibition of tumor growth by b-glucans through promoting CD4+ T cell immunomodulation and neutrophil-killing in mice. Carbohydr. Polym. 2019, 213: 370-381. 25.
7. Bingchao Duan#, Mengxia Li#, Ying Sun, Siwei Zou, Xiaojuan Xu*. Orally delivered antisense oligodeoxyribonucleotides of TNF-a via polysaccharide-based nanocomposites targeting intestinal inflammation. Adv. Healthcare Mater. 2019, 8(5): 1801389.
8. Bingchao Duan, Ying Sun, Siwei Zou, Xiaojuan Xu*. Nanoplatform constructed from a β-glucan and polydeoxyadenylic acid for cancer chemotherapy and imaging. Biomacromolecules 2019, 20 (4): 1567–1577.
9. Yan Meng, Xiaodan Shi, Liqin Cai, Sihai Zhang, Kan Ding, Shaoping Nie, Chuanfu Luo*, Xiaojuan Xu*, Lina Zhang*. Triple helix conformation of a polysaccharide determined with light scattering, AFM and molecular dynamic simulation. Macromolecules 2018, 51 (24): 10150
10. Zhaohua Ping, Ting Liu, Hui Xu, Yan Meng, Wenhua Li, Xiaojuan Xu*, Lina Zhang*. Construction of highly stable selenium nanoparticles embedded in hollow nanofibers of polysaccharide and their antitumor activities. Nano Res. 2017, 10: 3775–3789.