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过渡金属配合物的合成、生物活性及机理 蛋白质组学在药物开发和疾病诊断中的应用 核磁共振分子成像、磁性/光学探针肿瘤诊断、多模式影像指导下的肿瘤治疗

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Siu, Fung-Ming†; Lin, Iris Wing-Shan†; Yan, Kun†; Lok, Chun-Nam; Low, Kam-Hung; Leung, Thomas Yun-Chung; Lam, Tin-Lun; Che, Chi-Ming*. “Anticancer Dirhodium(II) Carboxylates as Potent Inhibitors of Ubiquitin-Proteasome System” Chemical Science 2012, 3, 1785-1793. (封面文章, †并列第一作者) Zhou, Jinyuan*; Yan, Kun; Zhu, He. “A Simple Model for Understanding the Origin of the Amide Proton Transfer MRI Signal in Tissue”, Appl. Magn. Reson 2012, 42, 393-402. Wang, Silun; Chen, Yifei; Lal, Bachchu, Ford, Eric; Tryggestad, Erik; Armour, Michael; Yan, Kun; Laterra, John; Zhou, Jinyuan*. “Evaluation of Radiation Necrosis and Malignant Glioma in Rat Models Using Diffusion Tensor MR Imaging”, J Neurooncol. 2012, 107, 51-60. Zhou, Jinyuan*; Tryggestad, Erik; Wen, Zhibo; Lal, Bachchu; Zhou, Tingting; Grossman, Rachel; Wang, Silun; Yan, Kun; Fu, De-Xue; Ford, Eric; Tyler, Betty; Blakeley, Jaishri; Laterra, John; van Zijl, Peter C.M. “Differentiation between glioma and radiation necrosis using molecular magnetic resonance imaging of endogenous proteins and peptides”, Nature Medicine 2011, 17, 130-134. Yan, Kun; Lok, Chun-Nam; Bierla, Katarzyna; Che, Chi-Ming*. “Gold(I) complex of N,N’-disubstituted cyclic thiourea with in vitro and in vivo anti-cancer properties - potent tight-binding inhibition of thioredoxin reductase”, Chem. Commun. 2010, 46, 7691–7693. (封面文章) Zhang, Zhi; Guo, Qian-ni; Lu, Yun-guo; Jia, Tao; Yan, Kun*; Li, Zao-ying*. “Interaction between novel porphyrin-dextran nanoparticles and human serum albumin”, J. Porphyrins Phthalocyanines 2010, 14, 264–270. Zhang, Zhi; He, Rui; Yan, Kun; Guo, Qian-ni; Lu, Yun-guo; Wang, Xu-xia; Lei, Hao; Li, Zao-ying*. “Synthesis and in vitro and in vivo evaluation of manganese(III) porphyrin–dextran as a novel MRI contrast agent”, Bioorg. Med. Chem. Lett. 2009, 19, 6675-6678. Siu, Fung-Ming; Ma, Dik-Lung; Cheung, Yee-Wai; Lok; Chun-Nam, Yan, Kun; Yang, zhiqi; Yang, Mengsu; Xu, SongXiao; Ko, Ben Chi-Bun; He, Qing-Yu; Che, Chi-Ming*. “Proteomic and transcriptomic study on the action of a cytotoxic saponin (Polyphyllin D): Induction of endoplasmic reticulum stress and mitochondriamediated apoptotic pathways”, Proteomics 2008, 8, 3105–3117.

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