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个人简介

​教育及科研经历 1987, 9-1991, 8 河南大学化学化工学院化学专业学习并获理学学士学位 1991, 9-1994, 6 南开大学元素所有机化学专业学习并获理学硕士学位 1994, 7-1996, 8 广州百花香料股份有限公司研发部工作(助理研究员) 1996, 9-1999, 6 南开大学元素所精细有机及农药化学专业并获理学博士学位(导师黄润秋教授) 1999, 7-2002,11 南开大学化学学院元素所工作(讲师、副教授) 2002,12-2003,12 法国国家科研中心(CNRS)精细化学研究所博士后 (合作教授: Dominique Cahard) 2004, 1-2005, 6 德国马谱(MPI)煤炭化学研究所博士后(合作教授:Manfred T. Reetz) 2008, 4-2008, 9 日本理化学研究所RIKEN(JSPS fellow)(合作教授:Mikiko Sodeoka) 2005, 7-至今 天津大学理学院化学系工作(教授)

研究领域

1、手性化合物不对称合成研究: (1)新型手性催化剂的设计合成; (2)催化不对称新反应及新合成方法研究; (3)具有生物活性的手性化合物设计合成 2、有机氟化学工程化研究: (1)含氟有机功能化合物的设计、合成及反应研究; (2)18F-PET成像探针及药物设计合成,主要用于肿瘤诊断; (3)天然产物及药物氟工程化修饰及活性筛选,主要用于创制新药物

近期论文

查看导师最新文章 (温馨提示:请注意重名现象,建议点开原文通过作者单位确认)

Xiaohua Luo, Wei Mao, Chen-Fei Liu, Yu-Qi Wang, Jing Nie,* Shi-Liang Shi,* Jun-An Ma*& Ming Joo Koh*. Enantioselective synthesis of multifunctional alkylboronates via N-heterocyclic carbene–nickel-catalysed carboboration of alkenes. Nature Synthesis. 2024. https://doi.org/10.1038/s44160-024-00492-x Xiaodong Tang,† Ming-Yue He,† Ran Guo, Hao-Nan Liu, Jing Nie, Ilan Marek, Jun-An Ma and Fa-Guang Zhang*. The Smallest Monofluorodiazoethane Reagent and Its [3 + 2] Cycloaddition Reactions. CCS Chem. 2024. DOI: 10.31635/ccschem.024.202403849 Ze-Long Mei, Cong-Cong Li, Xu Han, Yu-Chen Tian, Shuo-Han Li, Weidong Liu, Ge Qu, Manfred T. Reetz, Zhoutong Sun,* Jun-An Ma,* and Fa-Guang Zhang*. Enzymatic Stereodivergent Access to Fluorinated β‑Lactam Pharmacophores via Triple-Parameter Engineered Ketoreductases. ACS Catal. 2024, 14, 6358–6368. DOI: 10.1021/acscatal.4c00945. Weimin Xuan*and Jun-An Ma*. Pinpointing Acidic Residues in Proteins. ChemMedChem, 2024, 19, e202300623. DOI: 10.1002/cmdc.202300623 Xinyi Li, Fa-Guang Zhang, Jun-An Ma,* and Yongjun Liu*. Computational insights into the binding modes, keto-enol tautomerization and stereo-electronically controlled decarboxylation of oxaloacetate in the active site of Macrophomate synthase. Phys. Chem. Chem. Phys., 2024, DOI: 10.1039/D4CP00716F. Haonan Liu, Jianxu Chen, Zan Yang, Liuyin Jiang, Wenya Liu, Jun-An Ma,* and Saihu Liao*. Light-Controlled Cationic RAFT Polymerization of Vinyl Ethers Using N‑Arylacridinium Photocatalysts. Macromolecules, 2024. https://doi.org/10.1021/acs.macromol.4c00265. Ye Yuan, Muliang Zhang, Xiaodong Tang, Jared L. Piper, Zhi-Hui Peng, Jun-An Ma,* Jie Wu,* and Fa-Guang Zhang*. Photoinduced Defluorinative Branch-Selective Olefination of Multifluoro (Hetero)arenes. Org. Lett. 2023, 25, 883-888. https://doi.org/10.1021/acs.orglett.3c00115 Yue-Ji Chen, Jie Zheng, Jun-An Ma * , Fa-Guang Zhang *. Radical-initiated diazo-retaining nucleophilic addition reaction of trifluorodiazoethane and diazoacetate with 2Hazirines. Journal of Fluorine Chemistry, 2023. https://doi.org/10.1016/j.jfluchem.2023.110129 Meng Li, Jun-An Ma, and Saihu Liao*. Atom-Transfer Radical Polymerization of a SuFExable Vinyl Monomer and Polymer Library Construction via SuFEx Click Reaction. Macromolecules 2023, 56, 806-814. https://doi.org/10.1021/acs.macromol.2c01492 Guangrong Wang, Hui Shao, Jun-An Ma, and Saihu Liao*. Chalcogenide-Doped Anthracenes as Organophotocatalysts for Metal-Free Atom Transfer Radical Polymerization. Macromol. Chem. Phys. 2023, 224, 2200382. Feng-Ling Qing1*, Xin-Yuan Liu2*, Jun-An Ma3*, Qilong Shen1*, Qiuling Song4*, Pingping Tang5*. A Fruitful Decade of Organofluorine Chemistry: New Reagents and Reactions. CCS Chem. 2022. DOI: 10.31635/ccschem.022.202201935. Xuan-Yu Liu, Fa-Guang Zhang∗ , Jun-An Ma∗. Regioselective Construction of Coumarin-1,2,4-triazines via a Cs2CO3-Catalyzed [3+3] Cycloaddition Reaction. Synlett. 2022. DOI: 10.1055/a-1828-7504 Cheng-Feng Gao1, Yin Zhou1, Hai Ma2, Yue Zhang1, Jing Nie1, Fa-Guang Zhang1* & Jun-An Ma1*. Dual Incorporation of Trifluoromethyl and Cyano Groups into Pyrazole Pharmcophores via Silver-Catalyzed Cycloaddition Reaction of Trifluorodiazoethane. CCS Chem. 2022. DOI: 10.31635/ccschem.022.202201923 Xue-Qi Wang,a Fang-Fang Feng,a Jing Nie,a Fa-Guang Zhang,a,* and Jun-An Maa,*. Enantioselective Construction of Amino Carboxylic-Phosphonic Acid Derivatives Enabled by Chiral Amino Thiourea-Catalyzed Decarboxylative Mannich Reaction. Adv. Synth. Catal. 2022, 364, 1 –6. https://doi.org/10.1002/adsc.202200306 Yu-Ting Tian, Fa-Guang Zhang,* and Jun-An Ma*, Et3N-catalyzed direct cycloaddition reaction of allenoates with acceptor diazo compounds[J]. Tetrahedron, 2021, 81, 131922. DOI: 10.1016/j.tet.2021.131922 Yu-Ting Tian, Fa-Guang Zhang,* and Jun-An Ma*, Regioselective [3 + 2] Cycloaddition Reaction of 3‑Alkynoates with Seyferth−Gilbert Reagent[J]. J. Org. Chem. 2021, 86, 3574−3582. DOI: 10.1021/acs.joc.0c02957 Lu-Nan Zhou, Fang-Fang Feng, Chi Wai Cheung,* and Jun-An Ma*, Cu-Enabled [3 + 2] Annulation of In Situ Formed Nitrile Ylides with Aryldiazonium Salts: Access to 5‑Cyano-1,2,4-Triazoles[J]. Org. Lett. 2021, 23, 739−744. DOI: 10.1021/acs.orglett.0c03960 Hao-Qiang Cao, Jun-Kuan Li, Fa-Guang Zhang,* Dominique Cahard,* and Jun-An Ma*, Asymmetric Synthesis of Chiral Amino Carboxylic-Phosphonic Acid Derivatives[J]. Adv. Synth. Catal. 2021, 363, 688 – 729. DOI: 10.1002/adsc.202001345 Yu-Chen Tian, Jun-Kuan Li, Fa-Guang Zhang,* and Jun-An Ma*, Regioselective Decarboxylative Cycloaddition Route to Fully Substituted 3-CF3-Pyrazoles from Nitrilimines and Isoxazolidinediones[J]. Adv. Synth. Catal. 2021, 363, 1 –6. DOI: 10.1002/adsc.202100091 Fang-Fang Feng, Xue-Qi Wang, Long Sun, Chi Wai Cheung, Jing Nie,* and Jun-An Ma*. Switching of Enantioselectivity in the Cu-Catalyzed Asymmetric Decarboxylative Aldol Reaction of Tryptanthrin with β-Keto Acids: An Unexpected Counteranion Effect. DOI: 10.1021/acs.orglett.1c01315 Fang-Fang Feng, Xuan-Yu Liu, Chi Wai Cheung,* and Jun-An Ma*. Tungsten-Catalyzed Transamidation of Tertiary Alkyl Amides. ACS Catal. 2021, 11, 7070−7079. DOI: 10.1021/acscatal.1c01840 Shi-Jing Zhai, Fa-Guang Zhang*, Jun-An Ma*. Metal-free regioselective construction of 2-aryl-2H-tetrazol-5-yl diflfluoromethylene phosphonates. Chinese Chemical Letters. https://doi.org/10.1016/j.cclet.2021.08.007 Fa-Guang Zhang,* Zhen Chen, Xiaodong Tang, and Jun-An Ma*. Triazines: Syntheses and Inverse Electron-demand Diels−Alder Reactions. Chem. Rev. https://doi.org/10.1021/acs.chemrev.1c00611 Fang-Fang Feng, Jun-An Ma,* and Dominique Cahard*. Radical 1,5-Chloropentaflfluorosulfanylation of Unactivated Vinylcyclopropanes and Transformation into αSF5 Ketones. J. Org. Chem. https://doi.org/10.1021/acs.joc.1c01886 Yue-Ji Chen, Fa-Guang Zhang,* and Jun-An Ma*. Zinc-Enabled Annulation of Triflfluorodiazoethane with 2HAzirines to Construct Triflfluoromethyl Pyrazolines, Pyrazoles, and Pyridazines. Org. Lett. 2021, 23, 6062−6066. https://doi.org/10.1021/acs.orglett.1c02139 Catalytic regioselective construction of phenylthio- and phenoxyldifluoroalkyl tetrazoles from difluorodiazoketones. Hong-Song Shi, Shuo-Han Li, Fa-Guang Zhang *, and Jun-An Ma. Chem. Commun. DOI: 10.1039/d1cc05890h Shi-Jing Zhai,† Xing Peng,† Fa-Guang Zhang,*,†,‡ and Jun-An Ma*,†,‡. Catalytic Direct Regioselective Synthesis of Phosphonylated Tetrazoles from Aryl Diazonium Salts and Seyferth-Gilbert Reagent [J]. Org. Lett. 2019, 21, 9884−9888. DOI: 10.1021/acs.orglett.9b03800 Xing-Fa Tan, Fa-Guang Zhang and Jun-An Ma. Asymmetric synthesis of CF2-functionalized aziridines by combined strong Brønsted acid catalysis [J]. Beilstein J. Org. Chem. 2020, 16, 638–644.DOI: 10.3762/bjoc.16.60 Hao-Nan Liu, Hao-Qiang Cao, Chi Wai Cheung and Jun-An Ma. Cu-Mediated Expeditious Annulation of Alkyl 3-Aminoacrylates with Aryldiazonium Salts: Access to Alkyl N2-Aryl 1,2,3-Triazole-carboxylates for Druglike Molecular Synthesis [J]. Org. Lett. 2020, 22, 1396–1401.DOI: 10.1021/acs.orglett.0c00006 Ming-Yang Xiao, Zhen Chen, Fa-Guang Zhang, Jun-An Ma. Regioselective synthesis of carboxylic and fluoromethyl tetrazoles enabled by silver-catalyzed cycloaddition of diazoacetates and aryl diazonium salts [J]. Tetrahedron. 2020, 76, 131063. DOI: 10.1016/j.tet.2020.131063

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