刘小华 - 四川大学

个人简介

1996.9-2000.6 湖北师范学院化学系学习，获理学学士学位 2000.9-2003.6 四川大学化学学院分析化学专业学习，获理学硕士学位 2003.9-2006.6 四川大学化学学院有机化学专业学习，获理学博士学位 2006.7-2010.6 四川大学化学学院副教授，硕士生导师 2010.7-至今四川大学化学学院教授，2012年担任博士生导师 2011年获教育部新世纪优秀人才计划资助；2012年获国家自然科学基金委优秀青年基金资助；2013年入选四川省学术和技术带头人后备人选；获霍英东青年教师基金资助；2015年入选第二届国家高层次人才特殊支持计划青年人才，享受国务院政府特殊津贴专家；2016年获国家杰出青年科学基金资助；2017年国家百千万人才工程入选者和有突出贡献中青年专家；2018年入选四川省学术和技术带头人；2020年获全国三八红旗手称号；2021年当选英国皇家化学会会士。

研究领域

主要从事新型手性催化剂的设计合成、不对称催化反应、手性药物和生理活性化合物的高效高选择性合成研究。

近期论文

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Dong Zhang,# Maoping Pu,# Zhenzhong Liu, Yuqiao Zhou, Zhendong Yang, Xiaohua Liu,* Yun-Dong Wu,* and Xiaoming Feng,* J. Am. Chem. Soc. 2023, 145, ASAP, 10.1021/jacs.2c13810 Tangyu Zhan, Liangkun Yang, Qiyou Chen, Rui Weng, Xiaohua Liu,* Xiaoming Feng,* Chiral Lewis Acid-Catalyzed Norrish Type II Cyclization to Synthesize α-Oxazolidinones via Enantioselective Protonation, CCS Chem. 2023, 5, accepted, 10.31635/ccschem.022.202202405 Zhikun Wu,† Xiying Zhang,† Nian Xu, Xiaohua Liu,* Xiaoming Feng,* Asymmetric Catalytic Aerobic Oxidative Radical Addition/Hydroxylation/1,4-Aryl Migration Reaction of Olefins, ACS Catal. 2023, 13, 815−823. Yuhao Mo, Qiyou Chen, Jinzhao Li, Dong Ye, Yuqiao Zhou, Shunxi Dong, Xiaohua Liu,* Xiaoming Feng,* Asymmetric Catalytic Conjugate Addition of Cyanide to Chromones and β‑Substituted Cyclohexenones, ACS Catal. 2023, 13, 877−886. Yongyan Zhang, Jin Wu, Lichao Ning, Qianping Chen, Xiaoming Feng, Xiaohua Liu,* Enantioselective Synthesis of Tetrasubstituted Allenes via Addition/Arylation Tandem Reaction of 2-Activated 1,3-Enynes, Sci. China Chem. 2023, 66, 526−533. Siyuan Wang, Yuqiao Zhou, Wanlong Xiao, Zegong Li, Xiaohua Liu,* Xiaoming Feng,* Asymmetric Synthesis of Complex Tricyclo[3.2.2.0] Nonenes from Racemic Norcaradienes: Kinetic Resolution via Diels–Alder Reaction, Chem. Sci. 2023, 14, 1844−1851. Changli He, Xiaoxue Tang, Xin He, Yuqiao Zhou, Xiaohua Liu,* Xiaoming Feng,* Regio- and Enantioselective Conjugate Addition of β-Nitro α,β-Unsaturated Carbonyls to Construct 3-Alkenyl Disubstituted Oxindoles, Chin. Chem. Lett. 2023, 34, 107487. Wei Yang, Zhendong Yang, Long Chen, Yican Lu, Cefei Zhang, Zhishan Su, Xiaohua Liu,* Xiaoming Feng,* Chiral Nickel(II) Complex Catalyzed Asymmetric (3 + 2) Cycloaddition of α-Diazo Pyrazoleamides with 2-Siloxy-1-alkenes, Chin. Chem. Lett. 2023, 33, 107791. Jianglin Qiao, Shiyu Wang, Xiaohua Liu,* Xiaoming Feng,* Enantioselective [3+2] Cycloaddition of Donor-Acceptor Aziridines and Imines to Construct 2,5-trans-Imidazolidines, Chem. Eur. J. 2023, 29, 10.1002/chem.202203757 Shunxi Dong, Xiaohua Liu,* Xiaoming Feng,* Asymmetric Catalytic Rearrangements with α‑Diazocarbonyl Compounds, Acc. Chem. Res. 2022, 55, 415−428. Xiaobin Lin,# Maoping Pu,# Xinpeng Sang, Shiyang Li, Xiaohua Liu,* Yun-Dong Wu,* Xiaoming Feng,* Asymmetric Catalytic (2+1) Cycloaddition of Thioketones to Synthesize Tetrasubstituted Thiiranes, Angew. Chem. Int. Ed. 2022, 61, e202201151. Wanlong Xiao, Lichao Ning, Shuang Xin, Shunxi Dong, Xiaohua Liu,* XiaomingFeng,* Enantioselective [2+2] Cycloaddition of Allenyl Imidewith Mono-, or Disubstituted Alkenes, Angew. Chem. Int. Ed. 2022, 61, e202211596. Lifeng Wang, Yuqiao Zhou, Zhishan Su, Fengcai Zhang, Weidi Cao, Xiaohua Liu,* Xiaoming Feng,* [3,3]-Sigmatropic Rearrangements of Naphthyl 1-Propargyl Ethers: para-Propargylation and Catalytic Asymmetric Dearomatization, Angew. Chem. Int. Ed. 2022, 61, e202211785. Han Yu, Tangyu Zhan, Yuqiao Zhou, Long Chen, Xiaohua Liu,* Xiaoming Feng,* Visible-Light-Activated Asymmetric Addition of Hydrocarbons to Pyridine-Based Ketones, ACS Catal. 2022, 12, 5136−5144. Yao Luo, Qi Wei, Liangkun Yang, Yuqiao Zhou, Weidi Cao, Zhishan Su, Xiaohua Liu,* Xiaoming Feng,* Enantioselective Radical Hydroacylation of α,β-Unsaturated Carbonyl Compounds with Aldehydes by Triplet Excited Anthraquinone, ACS Catal. 2022, 12, 12984−12992. Jiawen Lang, Siyuan Wang, Changli He, Xiaohua Liu,* Xiaoming Feng,* Asymmetric Synthesis of Isochromanone Derivatives via Trapping Carboxylic Oxonium Ylides and Aldol Cascade, Chem. Sci. 2022, 13, 1163−1168. Linfeng Hu, Jinzhao Li, Yongyan Zhang, Xiaoming Feng, Xiaohua Liu,* Enantioselective [1,2]-Stevens Rearrangement of Thiosulfonates to Construct Dithio-substituted Quaternary Carbon Centers, Chem. Sci. 2022, 13, 4103–4108. Yi Li, Shuang Xin, Rui Weng, Xiaohua Liu,* Xiaoming Feng,* Asymmetric Synthesis of Chromanone Lactones via Vinylogous Conjugate Addition of Butenolide to 2-Ester Chromones, Chem. Sci. 2022, 13, 8871–8875. Peiran Ruan, Qiong Tang, Zun Yang, Xiaohua Liu,* Xiaoming Feng,* Enantioselective Formal [2+2+2] Cycloaddition of 1,3,5-Triazinanes to Construct Tetrahydropyrimidin-4-one Derivatives, Chem. Commun. 2022, 58, 1001−1004. Chaoqi Ke, Qiuhui Cao, Yao Luo, Xiaohua Liu,* Xiaoming Feng,* Catalytic Asymmetric Amination of Azlactones with Azobenzenes, Chem. Commun. 2022, 58, 5881−5884. Qingfa Tan, Qianping Chen, Zitong Zhu, Xiaohua Liu,* Asymmetric Organocatalytic Sulfenylation for the Construction of a Diheteroatom-bearing Tetrasubstituted Carbon Centre, Chem. Commun. 2022, 58, 9686–9689. Yi Li, Wang-Yuren Li, Xiaoxue Tang, Xiaohua Liu,* Xiaoming Feng,* Synthesis of Chiral Pyridine-oxazolines via Catalytic Asymmetric Heine Reaction of meso-N-(2-picolinoyl)-aziridines, Org. Chem. Front. 2022, 9, 1531−1535. Jinzhao Li, Lichao Ning, Qingfa Tan, Xiaoming Feng, Xiaohua Liu,* Asymmetric Sonogashira C(sp3 )-C(sp) Bond Coupling Enabled by Copper(I) Complex of New Guanidine-hybrid Ligand, Org. Chem. Front. 2022, 9, 6312−6318. Fei Tan,# Maoping Pu,# Jun He, Jinzhao Li, Jian Yang, Shunxi Dong, Xiaohua Liu,* Yun-Dong Wu,* Xiaoming Feng,* Catalytic Asymmetric Homologation of Ketones with α-Alkyl-α-diazoesters, J. Am. Chem. Soc. 2021, 143, 2394−2402. Wei Yang,# Maoping Pu,# Xiaobin Lin, Min Chen, Yanji Song, Xiaohua Liu,* Yun-Dong Wu,* Xiaoming Feng,* Enantioselective Formal Vinylogous N−H Insertion of Secondary Aliphatic Amines Catalyzed by a High-Spin Cobalt(II) Complex, J. Am. Chem. Soc. 2021, 143, 9648−9656. Wen Liu,# Maoping Pu,# Jun He, Tinghui Zhang, Shunxi Dong, Xiaohua Liu,* Yun-Dong Wu,* Xiaoming Feng,* Iron-Catalyzed Enantioselective Radical Carboazidation and Diazidation of , a,b-Unsaturated Carbonyl Compounds, J. Am. Chem. Soc. 2021, 143, 11856−11863. Long Chen,# Maoping Pu,# Shiyang Li, Xinpeng Sang, Xiaohua Liu,* Yun-Dong Wu,* and Xiaoming Feng,* Enantioselective Synthesis of Nitriles Containing a Quaternary Carbon Center by Michael Reactions of Silyl Ketene Imines with 1‑Acrylpyrazoles, J. Am. Chem. Soc. 2021, 143, 19091–19098. Yong Xia, Xiaohua Liu,* Xiaoming Feng,* Asymmetric Catalytic Reactions of Donor-Acceptor Cyclopropanes, Angew. Chem. Int. Ed. 2021, 60, 9192–9204. Jinzhao Li, Yuhao Mo, Liqiao Yan, Xiaoming Feng, Zhishan Su,* Xiaohua Liu,* Organocatalytic Stereoselective [8+2] Cycloaddition of Tropones with Azlactones, CCS Chem. 2021, 3, 784–793. Xia Zhong, Ziwei Zhong, Zhikun Wu, Zhen Ye, Yuxiang Feng, Shunxi Dong, Xiaohua Liu,* Qian Peng,* Xiaoming Feng,* Chiral Lewis Acid-bonded Picolinaldehyde Enables Enantiodivergent Carbonyl Catalysis in Mannich/Condensation Reaction of Glycine Ester, Chem. Sci. 2021, 12, 4353–4360. Lihua Xie, Yi Li, Shunxi Dong, Xiaoming Feng, Xiaohua Liu,* Catalytic Asymmetric Formal [3+2] Cycloaddition of Isatogens with Azlactones to Construct Indolin-3-one Derivatives, Chem. Commun., 2021, 57, 239−242. Qingfa Tan, Han Yu, Yao Luo, Fenzhen Chang, Xiaohua Liu,* Yuqiao Zhou,* Xiaoming Feng,* Asymmetric Catalytic [4+3] Cycloaddition of ortho-Quinone Methides with Oxirances, Chem. Commun., 2021, 57, 3018−3021. Linfeng Hu, Weidi Cao, Kaixuan Wang, Xiaohua Liu,* Xiaoming Feng,* Asymmetric Synthesis of Dihydrocarbazoles through Friedel-Crafts Alkylation/annulation Sequential Reaction of Indoles, Chem. Commun., 2021, 57, 13138−13141. Jian Xu, Runze Li, Nian Xu, Xiaohua Liu,* Fei Wang,* Xiaoming Feng,* Enantioselective [4 + 2] Cycloaddition/Cyclization Cascade Reaction and Total Synthesis of cis-Bis(cyclotryptamine) Alkaloids, Org. Lett. 2021, 23, 1856−1861. Qianwen He, Dong Zhang, Fengcai Zhang, Xiaohua Liu,* Xiaoming Feng,* Asymmetric Catalytic Epoxidation of Terminal Enones for the Synthesis of Triazole Antifungal Agents, Org. Lett. 2021, 23, 6961−6966. Wenkun Yang, Pei Dong, Jian Xu, Jian Yang, Xiaohua Liu,* Xiaoming Feng,* Enantioselective synthesis of 3-substituted 3-amino-2-oxindoles via amination with anilines, Chem. Eur. J. 2021, 27, 9272−9275. Chaoqi Ke, Zhenzhong Liu, Sai Ruan, Xiaoming Feng, Xiaohua Liu,* Organocatalytic Asymmetric Synthesis of Benzothiazolopyrimidines via a [4 + 2] Cycloaddition of Azlactones with 2-Benzothiazolimines, Org. Chem. Front. 2021, 8, 5705−5709. Peng Zhao, Zegong Li, Jun He, Xiaohua Liu,* Xiaoming Feng,* Asymmetric Catalytic 1,3-Dipolar Cycloaddition of α-Diazoesters for Synthesis of 1-Pyrazoline-based Spirochromanones and Beyond, Sci. China Chem. 2021, 64, 1355−1360. Peng Zhao, Zi Zeng, Xiaoming Feng,* Xiaohua Liu,* Multisubstituted Pyrazole Synthesis via [3+2] Cycloaddition/Rearrangement/N-H Insertion Cascade Reaction of α-Diazoesters and Ynones, Chin. Chem. Lett. 2021, 32, 132−135. Yi Li, Hao Pan, Wangyuren Li, Xiaoming Feng, Xiaohua Liu,* Enantioselective Nucleophilic Aromatic Substitution Reaction of Azlactones to Synthesize Quaternary α-Amino Acid Derivatives, Synlett 2021, 32, 587−592. Weidi Cao, Xiaohua Liu,* Asymmetric Formal Hetero-Ene Reaction of Allylgold Intermediates, Chin. J. Org. Chem. 2021, 41, 857−858. Dong Zhang, Zhisan Su, Qianwen He, Zhikun Wu, Yuqiao Zhou, Chenjing Pan, Xiaohua Liu,* Xiaoming Feng,* Diversified Transformations of Tetrahydroindolizines to Construct Chiral 3-Arylindolizines and Dicarbofunctionalized 1,5-Diketones, J. Am. Chem. Soc. 2020, 142, 15975−15985. Xiying Zhang, Wangbin Wu, Weidi Cao, Han Yu, Xi Xu, Xiaohua Liu,* Xiaoming Feng,* Enantioselective Radical-Polar Crossover Reactions of Indanonecarboxamides with Alkenes, Angew. Chem. Int. Ed. 2020, 59, 4846−4850. Tengfei Kang, Liuzhen Hou, Sai Ruan, Weidi Cao, Xiaohua Liu,* Xiaoming Feng,* Lewis acid-catalyzed asymmetric reactions of β,γ-unsaturated 2-acyl imidazoles, Nat. Commun. 2020, 11, 3869. Xiaobin Lin, Zheng Tan, Wenkun Yang, Wei Yang, Xiaohua Liu,* Xiaoming Feng,* Chiral Cobalt(ΙΙ) Complex Catalyzed Asymmetric [2,3]-Sigmatropic Rearrangement of Allylic Selenides with α-Diazo Pyrazoleamides, CCS Chem. 2020, 2, 1423–1433. Jian Xu, Ziwei Zhong, Mingyi Jiang, Yuqiao Zhou, Xiaohua Liu,* Xiaoming Feng,* Asymmetric Catalytic Concise Synthesis of Hetero-3,3ʹ-Bisoxindoles for the Construction of Bispyrroloindoline Alkaloids, CCS Chem. 2020, 2, 1894–1902. Zhen Wang, Xiaohua Liu,* Xiaoming Feng,* Asymmetric Catalysis Enabled by Chiral N,N'-Dioxide–Nickel(II) Complexes, Aldrichimica ACTA, 2020, 53, 3−10. Qianchi Lin, Bowen Hu, Xi Xu, Shunxi Dong, Xiaohua Liu,* Xiaoming Feng,* Chiral N,Nʹ-Dioxide/Mg(OTf)2 Complex-Catalyzed Asymmetric [2,3]-Rearrangement of in situ Generated Ammonium Salts, Chem. Sci. 2020, 11, 3068−3073. Bin Shen, Qianwen He, Shunxi Dong, Xiaohua Liu,* Xiaoming Feng,* Chiral Cobalt(II) Complex Catalyzed Enantioselective Aza-Piancatelli Rearrangement/Diels-Alder Cascade Reaction, Chem. Sci. 2020, 11, 3862−3867. Lifeng Wang, Pengfei Zhou, Qianchi Lin, Shunxi Dong, Xiaohua Liu,* Xiaoming Feng,* Chiral Fe(II) Complex Catalyzed Enantioselective [1,3] O-to-C Rearrangement of Alkyl Vinyl Ethers and Synthesis of Chromanols and Beyond, Chem. Sci. 2020, 11, 10101−10106. Sai Ruan, Xia Zhong, Quangang Chen, Xiaoming Feng, Xiaohua Liu,* An Asymmetric Hydrocyanation/Michael reaction of a-Diazoacetates via Cu(I)/Chiral Guanidine Catalysis, Chem. Commun. 2020, 56, 2155−2158. Wei Yang, Xiaobin Lin, Yongyan Zhang, Weidi Cao, Xiaohua Liu,* Xiaoming Feng,* Nickel(II)-catalyzed asymmetric thio-Claisen rearrangement of α-diazo pyrazoleamides with thioindoles, Chem. Commun. 2020, 56, 10002−10005. Dong Zhang, Shunxi Dong, Qianwen He, Yao Luo, Yun Liu, Xiaohua Liu,* Xiaoming Feng,* Enantioselective Dicarbofunctionalization of (E)-Alkenyloxindoles with Pyridinium Salts by Chiral Lewis Acid/Photo Relay Catalysis, Chem. Commun. 2020, 56, 12757−12760. Haipeng Hu, Jinxiu Xu, Fang Wang, Shunxi Dong, Xiaohua Liu,* Xiaoming Feng,* Chiral ScIII-N,N′‑Dioxide-Catalyzed 1,3-Dipolar Cycloaddition of Diaziridines with Chalcones, Org. Lett. 2020, 22, 93−97. Xi Xu, Shunxi Dong, LiLi Feng, Sijing Wang, Xiaohua Liu,* Xiaoming Feng,* Kinetic Resolution of Propargylic Ethers via [2,3]-Wittig Rearrangement to Synthesize Chiral α‑Hydroxyallenes, Org. Lett. 2020, 22, 2692−2696. Hang Zhang, Yao Luo, Chenhao Zhu, Shunxi Dong, Xiaohua Liu,* Xiaoming Feng,* Catalytic Asymmetric Addition Reactions of Formaldehyde N,Nʹ‑Dialkylhydrazone to Synthesize Chiral Nitrile Derivatives, Org. Lett. 2020, 22, 5217−5222. Xiaobin Lin, Wei Yang, Wenkun Yang, Xiaohua Liu,* Xiaoming Feng,* Asymmetric Catalytic [2,3] Stevens and Sommelet–Hauser Rearrangements of a-Diazo Pyrazoleamides with Sulfides, Angew. Chem. Int. Ed. 2019, 58, 13492–13498. Qian Xiong, Shunxi Dong, Yushuang Chen, Xiaohua Liu,* Xiaoming Feng,* Asymmetric Synthesis of Tetrazole and Dihydroisoquinoline Derivatives by Isocyanidebased Multicomponent Reactions, Nat. Commun. 2019, 10, 2116. Yu Zhang, Fengcai Zhang, Long Chen, Jian Xu, Xiaohua Liu,* Xiaoming Feng,* Asymmetric Synthesis of P-Stereogenic Compounds via Thulium(III)-Catalyzed Desymmetrization of Dialkynylphosphine Oxides, ACS Catal. 2019, 9, 4834−4840. Wangbin Wu, Weidi Cao, Linfeng Hu, Zhishan Su, Xiaohua Liu,* Xiaoming Feng,* Asymmetric Baeyer–Villiger Oxidation: Classical and Parallel Kinetic Resolution of 3-Substituted Cyclohexanones and Desymmetrization of meso-Disubstituted Cycloketones, Chem. Sci. 2019, 10, 7003−7008. Jian Yang, Peiran Ruan, Wei Yang, Xiaoming Feng, Xiaohua Liu,* Enantioselective carbene insertion into the N–H bond of benzophenone imine, Chem. Sci. 2019, 10, 10305−10309. Lihua Xie, Shunxi Dong, Qian Zhang, Xiaoming Feng, Xiaohua Liu,* Asymmetric Construction of Dihydrobenzofuran-2,5-dione Derivatives via Desymmetrization of p-Quinols with Azlactones, Chem. Commun. 2019, 55, 87−90. Pengfei Zhou, Xiaohua Liu,* Wangbin Wu, Chaoran Xu, Xiaoming Feng,* Catalytic Asymmetric Construction of β‑Azido Amides and Esters via Haloazidation, Org. Lett. 2019, 21, 1170−1175. Hang Zhang, Yao Luo, Dawei Li, Qian Yao, Shunxi Dong, Xiaohua Liu,* Xiaoming Feng,* Enantioselective Synthesis of 4-Hydroxy-dihydrocoumarins via Catalytic Ring Opening/Cycloaddition of Cyclobutenones, Org. Lett. 2019, 21, 2388–2392. Jiawen Lang, Yi Li, Tengfei Kang, Xiaoming Feng, Xiaohua Liu,* Organocatalytic Asymmetric Michael/Dieckmann Cyclization Reaction of Alkynones To Construct Spirocyclopentene Oxindoles, Org. Lett. 2019, 21, 6897−6902. Weidi Cao, Xiaoming Feng, Xiaohua Liu,* Reversal of enantioselectivity in chiral metal complex-catalyzed asymmetric reactions, Org. Biomol. Chem. 2019, 17, 6538−6550.