许华平 - 清华大学

个人简介

Work experience 2014.12- Professor, Department of Chemistry, Tsinghua University, China 2009.12-2014.12 Associate Professor, Department of Chemistry, Tsinghua University, China 2008.7-2009.12 Lecturer, Department of Chemistry, Tsinghua University, China 2006.8-2008.7 Postdoc. at MESA+ Institute for Nanotechnology, University of Twente, the Netherlands (Supervised by Prof. David N. Reinhoudt and Prof. Jurriaan Huskens) Education 2001.9-2006.7 PhD student in Polymer Chemistry and Physics, College of Chemistry, Jilin University, China (Supervised by Prof. Xi Zhang) 2004.4-2005.3 Exchange PhD student in University of Leuven, Belgium 1997.9-2001.7 Bachelor student in Polymer Materials & Engineering, College of Chemistry, Jilin University, China Awards and Honors 2023 XPLORER Prize 2021 Polymer Science Innovation Paper Award of Chinese Chemical Society 2018 Nano Research Young Innovator Awards in NanoBiotech 2018 2017 Leading Talent of National High-level personnel of special support program (” people plan “) 2016 Innovative Talents Cultivate Program (Youth Science and Technology Innovation Leader) from Ministry of Science and Technology 2015 Outstanding Young Talents of National High-level personnel of special support program (” people plan “) 2014 Natural Science Fund for Outstanding Young Scholars from NSFC 2012 Special Program for Fundamental Research of Young Faculties, Tsinghua University 2011 New Century Excellent Talents in University (Ministry of Education, China) 2011 Young Chemists Award of Chinese Chemical Society

研究领域

The synthesis and performance exploration of new polymer materials play a crucial role in advancing both fundamental scientific research and engineering applications. In 2010, we first reported the selenium-containing polymers with redox dual responsiveness, significantly contributing to the development of Se-containing polymers. In 2021, we prepared polytelluoxane in cells, an inorganic main-chain polymer composed entirely of VI group elements, for the first time. This discovery of polytelluoxanes bridges the gap between inorganic oxides and organic polymers. Moving forward, we plan to design and synthesize new non-carbon main-chain polymers and explore their material properties: 1. Exploration of novel polymerization methods and bonding mechanisms for selenium/tellurium-containing polymers. 2. Investigation of dynamic covalent bonds within chalcogen groups and corresponding dynamic materials with responsive properties. 3. Development of selenium/tellurium-containing nanomedicines, intracellular polymerization and catalysis. 4. Exploration of the potential applications of selenium/tellurium-containing polymers in the fields of recyclable degradation, radiation protection and detection, semiconductors, photocatalysis, optical materials, dielectric elastomers, Neutrino free double beta decay detection, etc. 5. Investigation of other novel non-carbon main-chain polymers.

近期论文

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He, C.; Liu, C.; Pan, S.; Tan, Y.; Guan, J.; Xu, H.*; Polyurethane with β-Selenocarbonyl Structure Enabling the Combination of Plastic Degradation and Waste Upcycling. Angew. Chem. Int. Ed.; 2023, 10.1002/anie.202317558. Xianyu, B.; Pan, S.; Gao, S.; Xu, H.*; Li, T.*; Selenium-Containing Nanocomplexes Achieve Dual Immune Checkpoint Blockade for NK Cell Reinvigoration. Small; 2023, 10.1002/smll.202306225. Tan, Y.; Guan, J.; Xu, H.*; Hyper-stable cholesteric heliconical architectures for monochromatic light separation. Matter; 2023, 6, 3121. Chen, N.; Li, S.; Zhao, P.; Liu, R.; Xie, Y.; Lin, J.; Nijhuis, C.; Xu, B.; Zhang, L.*; Xu, H.*; Li, Y.*; Extremelong-lifetimeself-assembledmonolayerforair-stablemolecularjunctions. Sci. Adv.; 2023, 9, eadh3412. Liu, C.; Si, J.; Cao, M.; Zhao, P.; Dai, Y.; Xu, H.*; Visualizing Chain Growth of Polytelluoxane via Polymerization Induced Emission. Adv. Sci.; 2023, 202304518. Bai, B.; Qi, S.; Yang, K.; Yu, X.; Jian, R.; Zhang, T.; Wang, D.; Meng, H.; Zhao, Y.; Xia, Y.*; Xu, H.*; Yu, G.*; Chen, Z.*; Self-Assembly of Selenium-Doped Carbon Quantum Dots as Antioxidants for Hepatic Ischemia-Reperfusion Injury Management. Small; 2023, 19, 202300217. Dai, Y.; Zhang, Z.; Daniels, M.; Bao, Y.; Guan, J.; Zhang, S.; Zhou, R.; Tan, Y; Liu, L.; Xiao, H.; Cui, S.; Xu, H.*; Polytelluoxane: A chalcogen polymer that bridges the gap between inorganic oxides and macromolecules. Chem; 2023, 9, 2006. Liu, C.; Xianyu, B.; Dai, Y.; Pan, S.; Li, T.; Xu, H.*; Intracellular Hyperbranched Polymerization for Circumventing Cancer Drug Resistance. ACS Nano; 2023, 17, 11905. Dai, Y.; Guan, J.; Zhang, S.; Pan, S.; Xianyu, B.; Ge Z.; Si, J.; He, C.; Xu, H.*; Tellurium-containing Polymers: Recent Developments and Trends. Prog. Polym. Sci. 2023, doi.org/10.1016/j.progpolymsci.2023.101678. Pan, S.; Guan, J.; Xianyu, B.; Tan, Y.; Li, T.*; Xu, H.*: A Nanotherapeutic Strategy to Reverse NK Cell Exhaustion. Adv. Mater., 2023, adma.202211370. Cao, M.; Tan, Y.; Xu, H.*: Mechanochemistry of dynamic chalcogen-containing polymers: a minireview. New Journal of Chemistry, 2023, 47, 5582. Li, X.; Yang, F.; Li, Y.; Liu, C.; Zhao, P.; Cao, Y.; Xu, H.*; Chen, Y.*: Diselenide as a Dual Functional Mechanophore Capable of Stress Self-reporting and Self-strengthening in Polyurethane Elastomers. CCS Chemistry, 2023, 5, 925. Si, J.; Zhao, P.; Guan, J.*; Ji, S.; Xu, H.*: Dynamic Fluorescent Patterning Based on Visible-light-responsive Diselenide Metathesis. Langmuir, 2022, 38, 13272. Zhao, P.; Cao, M.; Liu, C.; Dai, Y.; Tan, Y.; Ji, S.; Xu, H.*: Water-Enhanced and Remote Self-Healing Elastomers in Various Harsh Environments. ACS Appl. Mater. Interfaces, 2022, 14, 27413. Liu, C.; Ji, S.*; Xu, H.*: Rapidly reprogrammable actuation of liquid crystal elastomers. Matter, 2022, 3, 2397. Han, Y.; Liu, C.; Xu, H.*; Cao, Y.*: Engineering reversible hydrogels for 3D cell culture and release using diselenide catalyzed fast disulfide formation. Chin. J. Chem. 2022, 40, 1578. He, C.; Cao, M.; Liu, J.; Ge, Z.; Zhou, R.; Xu, H.*: Nanotechnology in the Olympic Winter Games and Beyond. ACS Nano 2022, 16, 4981. Zhang, L.; Dai, Y.; Pan, S.; Tan, Y.; Sun, C.; Cao, M.; Xu, H.*: Copper-Selenocysteine Quantum Dots for NIR-II Photothermally Enhanced Chemodynamic Therapy. ACS Appl. Bio. Mater. 2022, 5, 1794. Cao, M.; Zhao, P.; Liu, C.; Xia, J.; Xu, H.*: When Dynamic Diselenide Bonds meet Dynamic Imine Bonds in Polymeric Materials. Macromol. Rapid Commun. 2022, 2200083. Liu, C.; Tan, Y.; Xu, H.*: Functional Polymer Materials Based On Dynamic Covalent Chemistry. Science China Materials, 2022, 65, 2017. Pan, S.; Li, T.; Tan, Y.; Xu, H.*: Selenium-containing Nanoparticles Synergistically Enhance Pemetrexed&NK Cell-Based Chemoimmunotherapy. Biomaterials, 2022, 280, 121321. Zhao, P.; Xia, J.; Liu, J.; Tan, Y.; Ji, S.; Xu, H.*: Laser-Induced Remote Healing of Stretchable Diselenide-Containing Conductive Composites. ACS Appl. Mater. Interfaces, 2021, 13, 50422. Liu, C.#; Tan, Y.#; He, C.; Ji, S.*; Xu, H.*: Unconstrained 3D Shape Programming with Light-Induced Stress Gradient. Adv. Mater., 2021, 33, 2105194. Zhang, L.; Sun, C.; Tan, Y.; Xu, H.*: Selenium-Sulfur-Doped Carbon Dots with Thioredoxin Reductase Activity. CCS Chem., 2021, 3, 2249. Dai, Y.; Li, T.; Zhang, Z.; Tan, Y.; Pan, S.; Zhang, L.; Xu, H.*: Oxidative Polymerization in Living Cells. J. Am. Chem. Soc., 2021, 143, 10709. Pan, S.; Xu, H.*: ROS-responsive Tellurium-containing Polymers. Acta Polymerica Sinica, 2021, 52, 857. Sun, C.; Gao, S.; Tan, Y.; Zhang, Z.; Xu, H.*: Side-Chain Selenium-Grafted Polymers Combining Antiangiogenesis Treatment with Photodynamic Therapy and Chemotherapy. ACS Biomater. Sci. Eng., 2021, 7, 3201. Xia, J.; Xu, H.*: Selenium-containing Surface/interface Chemistry. Chemical Journal of Chinese Universities, 2021, 42, 997. Chen, Q.; Yang, Y.; Yu, Y.; Xu, H.*: “Reprocessable Thermosets”: Synthesis and Characterization of Vitrimer in the Undergraduate Lab Course. J. Chem. Edu., 2021, 98, 1429. Yang, J.; Pan, S.; Gao, S.; Li, T.; Xu, H.*: CO/chemosensitization/antiangiogenesis Synergistic Therapy with H2O2-responsive Diselenide-containing Polymer. Biomaterials, 2021, 271, 120721. Liu, C.#; Zhang, Z.#; Fan, Z.; He, C.; Tan, Y.; Xu, H.*: Adaptive Se-Te Metathesis Controlled by Cucurbituril-Based Host-Guest Interaction. Chem. Asian J. 2020, 15, 4321. Zhao, P.; Xu, C.*; Sun, C.; Xia, J.; Sun, L.; Li, J.; Xu, H.*: Exploring the Difference of Bonding Strength Between Silver(I) and Chalcogenides in Block Copolymer Systems. Polym. Chem. 2020, 11, 7087. Wu, Q.#; Yuan, Y.#; Chen, F.; Sun, C.; Xu, H.*; Chen, Y.*: Diselenide-Linked Polymers under Sonication. ACS Macro Lett., 2020, 9, 1547. Xia, J.; Tan, Y.; Xu, H.*: Selenium-containing Dynamic Covalent Polymers. Acta Polymerica Sinica, 2020, 51, 1190. Sun, C.; Tan, Y.; Xu, H.*: From Selenite to Diselenide-Containing Drug Delivery Systems. ACS Materials Lett. 2020, 2, 1173. Li, T.; Xu, H.*: Selenium-Containing Nanomaterials for Cancer Treatment. Cell Reports Physical Science, 2020, 1, 100111. Yang, J.; Pan, S.; Gao, S.; Dai, Y.; Xu, H.*: Anti-recurrence/metastasis and Chemosensitization Therapy with Thioredoxin Reductase-interfering Drug Delivery System. Biomaterials, 2020, 249, 120054. Dai, Y.; Zheng, K.; Tan, Y.; Xiang, W.; Xianyu, B.; Xu, H.*: Fischesserite-inspired Recyclable Se-Polyurethanes for Selective Gold Extraction. Advanced Sustainable Systems, 2020, 4, 2000072. Pan, S.; Yang, J.; Ji, S.; Li, T.; Gao, S.; Sun C.; Xu, H.*; Cancer Therapy by Targeting Thioredoxin Reductase Based on Selenium-Containing Dynamic Covalent Bond. CCS Chem., 2020, 2, 225. Gao, S.; Li, T.; Guo, Y.; Sun, C.; Xianyu, B.; Xu, H.*: Selenium-Containing Nanoparticles Combine the NK Cells Mediated Immunotherapy with Radiotherapy and Chemotherapy. Adv. Mater., 2020, 1907568. Liu, C.; Fan, Z., Tan, Y.; Fan, F.; Xu, H.*: Tunable Structural Color Patterns Based on the Visible-Light-Responsive Dynamic Diselenide Metathesis. Adv. Mater., 2020, 1907569. Li, T.; Pan, S.; Zhuang, H.; Gao, S; Xu, H.*: Selenium-Containing Carrier-Free Assemblies with Aggregation-Induced Emission Property Combine Cancer Radiotherapy with Chemotherapy. ACS Appl. Bio Mater., 2020, 3, 1283. Zhao, P.; Xia, J.; Cao, M.; Xu, H.*: Wavelength-Controlled Light-Responsive Polymer Vesicle Based on Se–S Dynamic Chemistry. ACS Macro Lett., 2020, 9, 163. Li, T.; Pan, S.; Gao, S.*; Xiang, W.; Sun, C.; Cao, W.; Xu, H.*: Diselenide-Pemetrexed Assemblies for Combined Cancer Immuno-, Radio-, and Chemotherapies. Angew. Chem. Int. Ed., 2020, 132, 2722. Xia, J.; Li, H.*; Xu, H.*: Measuring the Strength of S/Se Based Dynamic Covalent Bonds. Acta Polym. Sin., 2020, 2, 205. Fan, Z.; Xu, H.*: Recent Progress in the Biological Applications of Reactive Oxygen Species-Responsive Polymers. Polym. Rev. 2020, 60, 114. Sun, C.; Wang, L.; Xianyu, B.; Li, T.; Gao, S.*; Xu, H.*: Selenoxide Elimination Manipulate the Oxidative Stress to Improve the Antitumor Efficacy. Biomaterials, 2019, 119514. Cao, W.*; Xu, H.*: Selenium Containing Supra-amphiphiles. Mater. Chem. Front., 2019, 3, 2010. Fan, F.; Liu, C.; Wang, S.; Lv, J.; Li, W.*; Fu, Y.*; Xu, H.*: Swelling-Induced 3D Photopatterning on a Diselenide-Containing Elastomer. J. Mater. Chem. C 2019, 7, 10777. Xia, J.; Zhao, P.; Pan, S.; Xu, H.*: Diselenide-Containing Polymeric Vesicles with Osmotic Pressure Response. ACS Macro Letters 2019, 8, 629. Wang, L.; Zhu, K.; Cao, W.*; Sun, C.; Lu, C.; Xu, H.*: ROS-triggered Degradation of Selenide-containing Polymers Based on Selenoxide Elimination. Polym. Chem. 2019, 10, 2039. Xiang, W.; Li, Z.; Xu, C.; Li, J.*; Zhang, W.*; Xu, H.*: Quantifying the Bonding Strength of Gold-chalcogen Bonds in Block Copolymer Systems. Chem. Asian J. 2019, 14, 1481. Liu, C.; Xia, J.; Ji, S.; Fan, Z.; Xu, H.*: Visible-Light-Induced Metathesis Reaction between Diselenide and Ditelluride. Chem. Commun., 2019, 55, 2813. Xia, J.; Zhao, P.; Zheng, K.; Lu, C.; Yin, S.; Xu, H.*: Surface Modification Based on Diselenide Dynamic Chemistry: Towards Liquid Motion and Surface Bioconjugation. Angew. Chem. Int. Ed., 2019, 58, 542. Li, F.*; Yang, D.; Xu, H.*: Nonmetal Heteroatom Doped Carbon dots: Synthesis and Property. Chem. Eur. J., 2019, 25, 1165. Fan, F.; Ji, S.; Sun, C.; Liu, C.; Yu, Y.; Fu, Y.; Xu, H.*: Wavelength-Controlled Dynamic Metathesis: A Light-Driven Exchange Reaction Between Disulfide and Diselenide Bonds. Angew. Chem. Int. Ed., 2018, 57, 16426. Fan, F.; Gao, S.; Ji, S.; Fu, Y.*; Zhang, P.*; Xu, H.*: Gamma Radiation Responsive Side-chain Tellurium-containing Polymer for Cancer Therapy. Mater. Chem. Front., 2018, 2, 2109. Xia, J.; Li, T.; Lu, C.; Xu, H.*: Selenium-containing Polymer: Perspectives toward Diverse Applications in both Adaptive and Biomedical Materials. Macromolecules, 2018, 51, 7435. Li, F.; Li, Y.; Yang, X.; Han, X.; Jiao, Y.; Wei, T.; Yang, D.; Xu, H.*; Nie, G.*: Highly Fluorescent Chiral N-S-Doped Carbon Dots from Cysteine: Affecting Cellular Energy Metabolism. Angew. Chem. Int. Ed., 2018, 57, 2377. (VIP paper) Li, T.; Xiang, W.; Li, F.; Xu, H.*: Self-assembly Regulated Anticancer Activity of Platinum Coordinated Selenomethionine. Biomaterials, 2018, 157, 17. Li, F.; Li, T.; Han, X.; Zhuang, H.; Nie, G.; Xu, H.*: Nanomedicine Assembled by Coordinated Selenium-Platinum Complexes Can Selectively Induce Cytotoxicity in Cancer Cells by Targeting the Glutathione Antioxidant Defense System. ACS Biomaterials Science & Engineering, 2018, 4, 1954(Biomaterials Science and Engineering in China Special Issue) Zhou, W.; Li, H.; Xia, B.; Ji, W.; Ji, S.; Zhang, W.; Huang, W.*; Huo, F.*; Xu, H.*: Selenium-functionalized Metal-Organic Frameworks for Enzyme Mimics. Nano Research, 2018, 11, 5761. Ji, S.; Fan, F.; Sun, C.; Yu, Y.; Xu, H.*: Visible Light Induced Plasticity of Shape Memory Polymers. ACS Appl. Mater. Interfaces, 2017, 9, 33169. Wang, L.; Wang, W.; Cao, W.; Xu, H.*: Multi-hierarchical Responsive Polymers: Stepwise Oxidation of a Selenium- and Tellurium-Containing Block Copolymer with Sensitivity to both Chemical and Electrochemical Stimuli. Polym. Chem., 2017, 8, 4520. Li, F.; Li, T.; Sun, C.; Xia, J.; Jiao, Y.; Xu, H.*: Selenium-Doped Carbon Quantum Dots (Se-CQDs) for Free Radical Scavenging. Angew. Chem. Int. Ed., 2017, 56, 9910. Xia, J.; Li, F.; Ji, S.; Xu, H.*: Selenium-functionalized Graphene Oxide that Can Modulate the Balance of Reactive Oxygen Species. ACS Appl. Mater. Interfaces, 2017, 9, 21413. Li, F.; Li, T.; Sun, C.; Xia, J.; Xu, H.*: Near-Infrared Light Stimuli-responsive Synergistic Therapy Nanoplatforms Based on the Coordination of Tellurium-containing Block Polymer and Cisplatin for Cancer Treatment. Biomaterials, 2017, 133, 208. Ji, S.; El Mard, H.; Smet, M.; Dehaen, W.; Xu, H.*: Selenium Containing Macrocycles: Transformation between Se-N/Se-S/SeSe Bonds. Sci. China Chem., 2017, 60, 1191. Sun, C.; Ji, S.; Li, F.*; Xu, H.*: Diselenide-Containing Hyperbranched Polymer with Light-Induced Cytotoxicity. ACS Appl. Mater. Interfaces, 2017, 9, 12924. Zhou, W.; Wang, L.; Li, F.; Zhang, W.; Huang, W.*; Huo, F.*; Xu, H.*: Selenium-containing Polymer@metal-organic Frameworks Nanocomposites as an Efficient Multi-responsive Drug Delivery System. Adv. Funct. Mater., 2017, 27, 1605465. Xia, J.; Ji, S.; Xu, H.*: Diselenide Covalent Chemistry at the Interface: Stabilizing Asymmetric Diselenide-containing Polymer via Micelle Formation, Polym. Chem., 2016, 7, 6708. Cao, W.; Li, F.; Chen, R.; Xu, H.*: Tellurium-containing Nanoparticles for Controlled Delivery of Cisplatin Based on Coordination Interaction, RSC Adv., 2016, 6, 94033. Li, T.; Li, F.; Xiang, W.; Yi, Y.; Chen, Y.; Cheng, L.; Liu, Z.*; Xu., H.*: Selenium-containing Amphiphiles Reduced and Stabilized Gold Nanoparticles: Kill Cancer Cells via Reactive Oxygen Species, ACS Appl. Mater. Interfaces, 2016, 8, 22106. Fan, F.; Wang, L.; Li, F.; Fu, Y.*; Xu, H.*: Stimuli-Responsive Layer-by-Layer Tellurium-Containing Polymer Films for the Combination of Chemotherapy and Photodynamic Therapy. ACS Appl. Mater. Interfaces, 2016, 8, 17004. Wang, L.; Cao, W.; Xu, H.*: Tellurium-Containing Polymers: Towards Biomaterials and Optoelectronic Materials. ChemNanoMat, 2016, 2, 479. Ji, S.; Xia, J.; Xu, H.*: Dynamic Chemistry of Selenium: Se–N and Se–Se Dynamic Covalent Bonds in Polymeric Systems. ACS Macro Lett., 2016, 5, 78. Li, T.; Smet, M.; Dehaen, W. and Xu, H.*: Selenium–Platinum Coordination Dendrimers with Controlled Anti-Cancer Activity. ACS Appl. Mater. Interfaces, 2016, 8, 3609. (“Applied Materials and Interfaces in China” Special Issue) Cao, W.; Wang, L.; Xu, H.*: Selenium/tellurium Containing Polymer Materials in Nanobiotechnology. Nano Today, 2015, 10, 717. Ji, S.; Cao, W.; Yu, Y. and Xu, H.*: Visible-Light-Induced Self-Healing Diselenide-Containing Polyurethane Elastomer. Adv. Mater., 2015, 27, 7740. Wang L.; Fan F.; Cao W. and Xu H.*: Ultra-sensitive ROS-responsive Coassemblies of Tellurium-Containing Molecules and Phospholipids, ACS Appl. Mater. Interfaces, 2015, 7, 16054. Cao, W.; Gu, Y.; Li, T.; Xu, H.*: Ultra-sensitive ROS-responsive Tellurium-containing Polymers. Chem. Commun., 2015, 51, 7069. Fang, R.; Xu, H.*; Cao, W.; Yang, L.; Zhang, X.*: Reactive Oxygen Species (ROS)-responsive Tellurium-containing Hyperbranched Polymer. Polym. Chem., 2015, 6, 2817. Cao, W.; Wang, L.; Xu, H.*: Coordination Responsive Tellurium-containing Multilayer Film for Controlled Delivery. Chem. Commun., 2015, 51, 5520. Huang, X.; Fang, R.; Wang, D.; Wang, J.; Xu, H.*; Wang, Y.*; Zhang, X.: Tuning Polymeric Amphiphilicity via Se-N Interactions: towards One-step Double Emulsion for Highly Selective Enzyme Mimics. Small, 2015, 11, 1537.

学术兼职

ACS Biomaterials Science & Engineering副主编 ACS Macro Letters编委 Supramolecular Materials编委 Organics副主编 Nanomaterials编委《化学教育》编委会委员《大学化学》编委会委员《高等学校化学学报》青年执行编委北京市化学会副秘书长中国化学会化学学科教育委员会副主任中国化学会青年工作者委员会委员中国生物材料学会生物医用高分子材料分会委员中国生物材料学会生物材料表界面工程分会第一届常务委员中国生物物理学会纳米酶分会委员