朱守非 - 南开大学 - 元素有机化学国家重点实验室

个人简介

Educational Background 1996.09-2000.06 B.Sc., Nankai University (Advisor: Prof. Shou-He Xiang) 2000.09-2005.06 Ph.D., Nankai University (Advisor: Prof. Qi-Lin Zhou) 2012.03-2013.03 Postdoctoral Fellow, the University of Tokyo (Advisor: Prof. Eiichi Nakamura) Professional Career 2005.07-2008.12 Lecturer, Nankai University 2008.12-2013.12 Associate Professor, Nankai University 2013.12-present Professor, Nankai University Honors & Awards 2023 Outstanding Young Graduate Mentor Award Fund 2023 National Teaching Achievement Award (the Second Rank, R1) 2022 XPLORER PRIZE 2022 CCS-BASF Youth Knowledge Innovation Award 2019 The National Natural Science Award (the First-Rank, R3) 2019 Asian Rising Stars Lectureship Award, Federation of Asian Chemical Societies 2018 Chiral Chemistry Award for Your Investigates, Chinese Chemical Society 2018 Tianjin 131 Creative Team Leader 2017 National Program for Support of Science and Technology Innovation Leader 2016 The National Science Fund for Distinguished Young Scholars 2016 Tianjin Youth Wu-Si Medal 2015 Youth Science and Technology Innovation Leader (Ministry of Science and Technology of China) 2015 Tianjin Youth Science and Technology Innovation Leader 2015 Tianjin 131 Creative Talents Cultivation Project (First Class) 2015 Asian Core Program Lectureship Awards (from Hong Kong and Korea) 2015 Nankai-Jebsen Scholarships for Teachers 2014 Tianjin 131 Creative Talents Cultivation Project (Second Class) 2013 National Program for Support of Top-notch Young Professionals 2013 The 12th Tianjin Youth Award for Science and Technology 2013 Tianjin Natural Science Award (the First-Rank, R3) 2013 The 100 Young-Academic-Leader Project of Nankai University 2012 The Science Funds for Excellent Youth (National Natural Science Foundation of China) 2012 Young Chemist Award of Chinese Chemical Society 2010 the Program for New Century Excellent Talents in University (Ministry of Education of China) 2007 Tianjin Natural Science Award (the First-Rank, R3) 2004 Hong Kong Qiu-Shi Award for Graduate Students

研究领域

The hydrogen transfer processes are ubiquitous in catalytic organic reactions and many of them involving in the rate-determining or selectivity-determining steps. The development of efficient catalysts for controlling of hydrogen transfer in organic reactions is of critical for improving their efficiency but is still a significant challenge nowadays. Our group mainly studied three kinds of catalytic organic synthesis reactions with hydrogen transfer as the key step. We proposed the concept of "chiral proton shuttle catalyst", which realized a variety of challenging asymmetric proton transfer reactions. We developed a catalytic B-H bond insertion reaction, which provides a new opportunity for the structural diversity synthesis of organic boron. We developed a variety of new catalysts for hydride transfer reactions, which improved synthetic efficiency of many pharmaceuticals. The above findings have triggered the follow-up research from famous research institutions and been used in the production of chiral drugs by well-known pharmaceutical companies.

近期论文

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Qiao Zhang, Xiang-Yu Liu, Yan-Dong Zhang, Ming-Yao Huang, Xin-Yu Zhang, Shou-Fei Zhu*. Iron-catalyzed C(sp3)-C(sp3) coupling to construct quaternary carbon centers. J. Am. Chem. Soc. 2024, DOI: 10.1021/jacs.3c14032. Peng He, Meng-Yang Hu, Jin-Hong Li, Tian-Zhang Qiao, Yi-Lin Lu, Shou-Fei Zhu*. Spin effect on redox acceleration and regioselectivity in Fe-catalyzed alkyne hydrosilylation. Natl. Sci. Rev. 2023, DOI: 10.1093/nsr/nwad324. https://doi.org/10.1093/nsr/nwad324 Lu-Jie Li#, Yuli He#, Yunhui Yang#, Jun Guo#, Zhan Lu*, Congyang Wang*, Shaolin Zhu*, Shou-Fei Zhu*. Recent advances in Mn, Fe, Co, Ni-catalyzed organic reactions. CCS Chem. 2023, DOI: 10.31635/ccschem.023.202303412. Wei Sun, Meng-Yang Hu, Zhan-Sheng Lu, Ming-Yao Huang, Xin-Yu Zhang, Shou-Fei Zhu*. Iron-Catalyzed Stereoconvergent 1,4-Hydrosilylation of Conjugated Dienes. Angew. Chem. Int. Ed. 2023, e202315473. Hao Shao#, Wenheng Liu#, Muhan Liu, Haibing He, Qi-Lin Zhou, Shou-Fei Zhu*, Shuanhu Gao*. Asymmetric synthesis of cyclopamine, a Hedgehog (Hh) signaling pathway inhibitor. J. Am. Chem. Soc. 2023, DOI: https://doi.org/10.1021/jacs.3c10362. Yan-Mei He#, Yuan-Zheng Cheng#, Yingdong Duan#, Yan-Dong Zhang#, Qing-Hua Fan*, Shu-Li You*, Sanzhong Luo*, Shou-Fei Zhu*, Xue-Feng Fu*, Qi-Lin Zhou*. Recent progress of asymmetric catalysis from a chinese perspective. CCS Chem. 2023, DOI: 10.31635/ccschem.023.202303347. https://doi.org/10.31635/ccschem.023.202303347 Feng-Kai Guo, Yi-Lin Lu, Ming-Yao Huang, Ji-Min Yang, Jia-Lei Guo, Zi-Yi Wan, Shou-Fei Zhu*, Wittig/B–H insertion reaction: a unique access to trisubstituted Z-alkenes, Sci. Adv. 2023, 9, eadj2486. Hua-Wei Liu, Peng He, Wen-Tao Li, Wei Sun, Kai Shi, You-Qin Wang, Qian-Kun Mo, Xin-Yu Zhang, Shou-Fei Zhu*, Catalyst-oriented design based on elementary reactions (CODER) for triarylamine synthesis, Angew. Chem. Int. Ed. 2023, e202309111. Wei-Na Wang, Qiang Huang, Ye Jin, Qi-Lin Zhou, Shou-Fei Zhu*, Iron-catalyzed alkenylzincation of internal alkynes, Chin. J. Chem. 2023, DOI: 10.1002/cjoc.202300356. Hui-Na Zou, Meng-Lin Huang, Ming-Yao Huang, Yu-Xuan Su, Jing-Wei Zhang, Xin-Yu Zhang, Shou-Fei Zhu*, Chiral gem-difluoroalkyl reagents: gem-difluoroalkyl propargylic borons and gem-difluoroalkyl α-allenols, Chem. Sci. 2023, 14, 9186–9190. Wen-Tao Li, Qiao Zhang, Meng-Yang Hu, Shou-Fei Zhu*, Iron-catalyzed alkene hydroalumination, Org. Lett. 2023, 25, 5646–5649. 孙伟，朱守非，铁系金属催化烯烃与三级硅烷的硅氢化反应研究进展，《有机化学》，2023，DOI: 10.6023/cjoc202305016.（Wei Sun, Shou-Fei Zhu, Hydrosilylation reactions of alkene with tertiary silanes catalyzed by iron-series metals, Chin. J. Org. Chem. 2023, DOI: 10.6023/cjoc202305016） Yu-Xuan Su; Ming-Yao Huang; Shou-Fei Zhu*, Catalytic N-H insertion reactions with α-diazoacetates: an efficient method for enantioselective amino acid synthesis. ChemCatChem 2023, e202300539. Yan-Dong Zhang, Shou-Fei Zhu*, Perspective for phosphine ligands with cyclopropane backbone, Acta Chim. Sinica 2023, 81, 777-783. (张艳东朱守非*, 环丙烷骨架膦配体的研究展望, 《化学学报》 2023, 81, 777-783.) Xiao Xiao, Kai-Ni Xu, Zhong-Hua Gao, Zhou-Hao Zhu, Chang-Qing Ye, Bao-Guo Zhao*, San-Zhong Luo*, Song Ye*, Yong-Gui Zhou*, Sen-Miao Xu*, Shou-Fei Zhu*, Hong-Li Bao*, Wei Sun*, Xiao-Ming Wang*, Kui-Ling Ding*, Biomimetic asymmetric catalysis. Sci China Chem, 2023, 66, 1553–1633. Jin Cao, Yu-Xuan Su, Xin-Yu Zhang, Shou-Fei Zhu*, Highly Enantioselective Brønsted Acid Catalyzed Heyns Rear-rangement, Angew. Chem. Int. Ed. 2023, 62, e202212976. Jin Cao, Shou-Fei Zhu*, Chiral proton-transfer shuttle catalysts promoted enantioselective Nazarov cyclization, Synlett 2023, 34, 29-39. Ming-Yao Huang, Shou-Fei Zhu*, Catalytic reactions for enantioselective transfers of donor-substituted carbenes, Chem Catalysis 2022, DOI: 10.1016/j.checat.2022.10.016. Jin Cao, Yu-Xuan Su, Xin-Yu Zhang, Shou-Fei Zhu*, Highly Enantioselective Brønsted Acid Catalyzed Heyns Rear-rangement, Angew. Chem. Int. Ed. 2022, DOI:10.1002/anie.202212976 Jin Cao, Shou-Fei Zhu*, Chiral proton-transfer shuttle catalysts promoted enantioselective Nazarov cyclization, Synlett 2022, DOI: 10.1055/a-1967-1175. You Li#, Yu-Xuan Su#, Yu-Tao Zhao, Lu Liu, Mao-Lin Li, Shou-Fei Zhu*, Enantioselective synthesis of unnatural carbamate-protected α-alkyl amino esters via N–H bond insertion reactions, ACS Catal. 2022, 12, 13143–13148. Hui-Na Zou, Yu-Tao Zhao, Liang-Liang Yang, Ming-Yao Huang, Jing-Wei Zhang, Meng-Lin Huang, Shou-Fei Zhu*, Catalytic asymmetric synthesis of chiral propargylic boron com-pounds through B–H bond insertion reactions, ACS Catal. 2022, 12, 10654–10660. Yan-Dong Zhang, Xiao-Yu Li, Qian-Kun Mo, Wen-Bin Shi, Jia-Bao Zhao, Shou-Fei Zhu*, Highly Regioselective Cobalt-Catalyzed Hydroboration of Internal Alkynes, Angew. Chem. Int. Ed. 2022, 61, e202208473 Wen-Tao Li, Meng-Yang Hu, Jun-Wen Xiong, Xin-Yu Zhang, Shou-Fei Zhu*, Iron-Catalyzed Hydroalumination of Internal Alkynes, Chem. Sci. 2022, 13, 7873-7879. Ming-Yao Huang, Yu-Tao Zhao, Cheng-Da Zhang, Shou-Fei Zhu*, Highly Regio-, Stereo-, and Enantioselective Copper-Catalyzed B–H Bond Insertion of α-Silylcarbenes: Efficient Access to Chiral Allylic gem-Silylboranes, Angew. Chem. Int. Ed. 2022, 61, e202203343. Wei Sun, Ming-Peng Li, Lu-Jie Li, Qiang Huang, Meng-Yang Hu, Shou-Fei Zhu*, Phenanthroline-Imine Ligands for Iron-Catalyzed Alkene Hydrosilylation, Chem. Sci. 2022,13, 2721-2728. Qiang Huang, Wei-Na Wang, Shou-Fei Zhu*, Iron-Catalyzed Alkylzincation of Terminal Alkynes, ACS Catal. 2022, 12, 2581–2588. Qiang Huang,Yu-Xuan Su,Wei Sun,Meng-Yang Hu,Wei-Na Wang,Shou-Fei Zhu*, Iron-Catalyzed Vinylzincation of Terminal Alkynes,J. Am. Chem. Soc. 2022, 144, 515-526. Peng He, Meng-Yang Hu, Xin-Yu Zhang, Shou-Fei Zhu*, Transition-metal catalyzed stereo- and regioselective hydrosilylation of unsymmetrical alkynes, Synthesis 2022,54,49-66. Ming-Yao Huang, Shou-Fei Zhu*, Uncommon carbene insertion reactions, Chem. Sci. 2021,12,15790-15801. Yu-Tao Zhao,Yu-Xuan Su, Xiao-Yu Li,Liang-Liang Yang,Ming-Yao Huang,Shou-Fei Zhu*,Dirhodium-Catalyzed Enantioselective B–H Bond Insertion of gem-Diaryl Carbenes: Efficient Access to gem-Diarylmethine Boranes.Angew. Chem. Int. Ed. 2021,60,24214-24219. Shou-Fei Zhu*, Catalytic hydrogen transfer reactions,Chin.J.Chem.2021,39,3211-3218. Ming-Yao Huang†, Yu-Tao Zhao†, Hao Chai, Cheng-Da Zhang, Shou-Fei Zhu*, Copper-catalyzed ring-opening/borylation of cyclopropenes, CCS Chem. 2021, 3, 1721-1726. (Ming-Yao Huang and Yu-Tao Zhao contributed equally to this work) Liang-Liang Yang, Jin Cao, Tian-Yuan Zhao, Shou-Fei Zhu*, Qi-Lin Zhou*, Chiral dirhodium tetraphosphate - catalyzed enantioselective Si–H bond insertion of α-aryldiazoacetates, J. Org. Chem. 2021, 86, 9692-9698. Yan-Dong Zhang, Shou-Fei Zhu*, Chromium-Catalyzed Deoxygenative Hydroboration of Nitro Compounds, Chin. J. Org. Chem. 2021, 41, 1255-1256. Tian-Yuan Zhao, Ke Li, Liang-Liang Yang, Shou-Fei Zhu, Qi-Lin Zhou*, Nickel-catalyzed desymmetrizing cyclization of 1,6-dienes to construct quaternary stereocenters, Org. Lett. 2021, 23, 3814-3817. Chu Gong, Yutao Zhao, Dongmei Zhang, Jie Wang, Chaonan Mu, Wei Wang, Shoufei Zhu, Xinxing Zhang*, Investigation of the Acid-Mediated Photosensitized Reactions of Amphiphilic α‑Keto Acids at the Air−Water Interface Using FieldInduced Droplet Ionization. J. Am. Soc. Mass Spectrom. 2021, DOI: 10.1021/jasms.1c00022.