鞠熀先 - 南京大学 - 化学化工学院

个人简介

鞠熀先教授，1964年11月生，1986、1989、1992年分别获南京大学理学学士、硕士与博士学位后留校任教，1996-1997年为加拿大Montreal大学博士后，1999年任南京大学教授，2003年获国家杰出青年科学基金，2007年教育部教授、2009年为“973”计划项目首席科学家，2011年获国务院政府特殊津贴，现为生命分析化学国家重点实验室主任，国际电化学会会士、英国皇家化学会会士。曾为国家自然科学基金创新研究群体的负责人，现兼任中国仪器仪表学会分析仪器分会副理事长、电分析化学专家组主任、化学传感器专家组副主任；中国化学会分析化学学科委员会副主任、有机分析专业委员会副主任、化学生物学专业委员会委员、糖化学专业委员会委员；中国生物工程学会生物传感-生物芯片-纳米生物技术专业委员会副主任，中国药理学会分析药理学专业委员会副主任，中国产学研合作促进会生物检测监测产业技术创新战略联盟副理事长；江苏省化学化工学会常务理事、分析化学专业委员会主任、质谱专业委员会副主任；江苏省分析测试协会副理事长。《Front. Chem.: Anal. Chem.》主编，《Sensors》、《J. Anal. Testing》、《Telomere & Telomerase》副主编，《Electroanalysis》、《Trends Anal. Chem.》、《Anal. Lett.》、《Chemosensors》、《中国科学：化学》（2006-2018）、《化学学报》、《Chin. J. Chem.》，《分析化学》、《Open Biomarkers J.》等刊编委。获中国化学会青年化学奖、梁树权分析化学基础研究奖、江苏省青年科学家奖称号，2019年获中国化学传感器首届雷磁杰出成就奖，2001、2009、2013年获教育部自然科学一等奖3项，2011、2014、2016年江苏省科学技术一等奖3项（2项合作），2008、2009、2019年江苏省科学技术二等奖3项，2015、2018年江苏省科学技术三等奖2项（合作），2017年重庆市科学技术一等奖（合作），2008、2009、2014年获中国分析测试协会科学技术一等奖3项，曾获教育部科技进步三等奖（第二完成人）2项。

研究领域

研究方向为生物分析化学与分子诊断，主要研究领域为免疫分析、细胞分析化学、纳米生物传感、生物成像和临床分子诊断

近期论文

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Junjie Hu, Fei Liu, Yunlong Chen, Guoqiang Shangguan, Huangxian Ju*, Mass spectrometric biosensing: A powerful approach for multiplexed analysis of clinical biomolecules, ACS Sensors https://doi.org/10.1021/acssensors.1c01394 Published: on Sept. 17 2021 Yue Zhang, Weiwei Chen, Xiaobo Zhang, Yuling He, Ying Liu*, Huangxian Ju*, Activating DNA nanomachine via computation across cancer cell membrane for precise therapy of solid tumor, J. Am. Chem. Soc. https://doi.org/10.1021/jacs.1c06361 Published: on Sept. 12, 2021 Huipu Liu, Yunlong Chen, Jiawei Wang, Yuanjiao Yang, Huangxian Ju*, Tug-of-war: Molecular dynamometers against living cells for analyzing sub-piconewton interaction of specific protein with cell membrane, Chem. Sci. 10.1039/D1SC03059K Published: on Sept. 2, 2021 Siqiao Li, Anwen Mao, Xiaojian Wang, Yuna Guo, Lu Liu, Lin Ding*, Huangxian Ju, A localized glyco-editing probe for revelating of protein-specific glycan functions on live cells, Materials Today https://doi.org/10.1016/j.mattod.2021.04.015 accepted on April 9, published online May 20, 2021 Jielin Chen, Mingpan Cheng, Gilmar Salgado, Petr Stadlbauer, Xiaobo Zhang, Samir Amrane, Aurore Guédin, Jiří Šponer, Huangxian Ju*, Jean-Louis Mergny*, Jun Zhou*, The beginning and the end: Flanking nucleotides incluce a paralle G-quadruplex topology, Nucleic Acids Res. 49(16), 9548-9559 (2021) 10.1093/nar/gkab681 Yuanjiao Yang, Yunlong Chen, Jingxing Guo, Huipu Liu, Huangxian Ju*, A perforation-induced SERS strategy for dynamic visualization of plasma membrane repair, iScience 24,102980 (2021) Xue Dong, Yu Du, Guanhui Zhao, Wei Cao, Dawei Fan, Xuan Kuang, Qin Wei*, Huangxian Ju*, Dual-signal electrochemiluminescence immunosensor for neuron-specific enolase detection based on “dual-potential” emitter Ru(bpy)32+ functionalized zinc-based metal-organic frameworks Biosens. Bioelectron. 192, 113505 (2021) Jinling Fu, Jie Wu, Rui Zhang, Qiang Wu*, Huangxian Ju*, Electrochemical biosensing of DENV nucleic acid amplified with triplet nanostructure-mediated dendritic hybridization chain reaction, Sens. Actuat. B 345, 130436 (2021) Rui Zhang, Jie Wu, Hang Ao, Jinling Fu, Bing Qiao, Qiang Wu*, Huangxian Ju*, Rolling circle amplified G-quadruplex/hemin DNAzyme for chemiluminescence immunoassay of SARS-CoV-2 protein, Anal. Chem. 93, 9933–9938 (2021) Yuling He, Xinyu Jin, Shuwen Guo, Hongxia Zhao, Ying Liu*, Huangxian Ju, Conjugated polymer-ferrocence nanoparticle as NIR-II light powered nano-amplifier to enhance chemodynamic therapy, ACS Applied Mater. Interf. 13, 31452–31461 (2021) Lizhen Chen, Jie Wu, Feng Yan, Huangxian Ju*, Monose modified organic electrochemical transistors for cell surface glycan analysis via competitive recognition to enzyme-labelled lectin, Microchim. Acta 188, 252 (2021) Yue Zhang, Xiaobo Zhang, Weiwei Chen, Yuling He, Ying Liu*, Huangxian Ju*, Self-assembled micelle responsive to quick NIR light irradiation for fast drug release and highly efficient cancer therapy, J. Controlled Release 336, 469–479 (2021) Yuling He, Shuwen Guo, Yue Zhang, Ying Liu*, Huangxian Ju, NIR-II reinforced intracellular cyclic reaction to enhance chemodynamic therapy with abundant H2O2 supply, Biomaterials 275, 120962 (2021) Mingpan Cheng, Jielin Chen, Huangxian Ju, Jun Zhou*, Jean-Louis Mergny*, Drivers of i-DNA formation in a variety of environments revealed by four-dimensional UV melting and annealing, J. Am. Chem. Soc. 143(20), 7792-7807 (2021) Xiaobo Zhang, Weiwei Chen, Xiaoyu Xie, Yue Zhang, Haibo Ma, Ying Liu*, Huangxian Ju*, Energy pumping by surface collectors on upconversion nanoparticle for extended transfer and efficient self-evaluable photodynamic therapy, CCS Chemistry 3, 1510–1521 (2021) Yanyun Fang, Yuyi Li, Rong He, Yue Zhang, Xiaobo Zhang, Ying Liu*, Huangxian Ju, In situ protease secretion visualization and metastatic lymph nodes imaging via a cell membrane anchored upconversion nanoprobe, Anal. Chem. 93(19), 7258–7265 (2021) Mingpan Cheng, Dehui Qiu, Liezel Tamon, Eva Maturová, Pavlína Víšková, Samir Amrane, Aurore Guédin, Jielin Chen, Laurent Lacroix, Huangxian Ju, Lukas Trantirek, Aleksandr B. Sahakyan, Jun Zhou*, Jean-Louis Mergny*, Thermal and pH stabilities of i-DNA: confronting in vitro experiments with models and in-cell NMR data, Angew. Chem. Int. Ed. 60(18), 10286-10294 (2021) Ningning Wang, Lizhen Chen, Weiwei Chen, Huangxian Ju*, Potential and color resolved electrochemiluminescence of polymer dots for array imaging of multiplex microRNA, Anal. Chem. 93(12), 5327–5333 (2021) Da Zhu, Yong Zhang, Songsong Bao, Ningning Wang, Siqi Yu, Rengan Luo, Jing Ma*, Huangxian Ju, Jianping Lei*, Dual intrareticular oxidation of mixed-ligand metal-organic frameworks for stepwise electrochemiluminescence, J. Am. Chem. Soc. 143(8), 3049-3053 (2021) Ningning Wang, Hang Gao, Yunzhi Li, Guangming Li, Weiwei Chen, Zhongchao Jin, Jianping Lei, Qin Wei, Huangxian Ju*, Dual intramolecular electron transfer for in situ coreactant-embedded electrochemiluminescence microimaging of membrane protein, Angew. Chem. Int. Ed. 60, 197–201 (2021)