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Shuan-Jing Wang, Jiahui Zhang, Jin-Zan Zhang, Ruo-Nan Ning, Chen-Chen Li, Xing Xu*, Min Jiang*, Wen-Wei Qiu*. Synthesis and Biological Evaluation of Heterocyclic Ring-Fused 20(S),Protopanaxadiol Derivatives as Potent Antiosteoporosis Agents. J. Med. Chem. 2023, 66, 11965-11984.
Xing-Zi Li, Shi-You Jiang, Guo-Qiang Li, Qian-Ru Jiang, Jue-Wan Li, Chen-Chen Li, Yu-Qin Han, Bao-Liang Song, Xin-Ran Ma*, Wei-Qi*, Wen-Wei Qiu*. Synthesis of heterocyclic ring-fused analogs of HMG499 as novel degraders of HMG-CoA reductase that lower cholesterol. Eur. J. Med. Chem. 2022, 236, 114323.
Ao Hu, Jing-Zan Zhang, Jie Wang, Chen-Chen Li, Meng Yuan, Gang Deng, Zi-Cun Lin, Zhi-Ping Qiu, Hu-Yue Liu, Xian-Wei Wang, Peng-Cheng Wei, Xiao He, Xiaolu Zhao*, Wen-Wei Qiu* and Bao-Liang Song*. Cholesterylation of Smoothened is a calcium-accelerated autoreaction involving an intramolecular ester intermediate. Cell Research 2022, 32, 288-301.
Xing-Zi Li, Chen-Chen Li, Cheng-Yu Jiang, Zhi-Liang Jing, Xiang-Zhong Gu, Hao-Jie Ni, Wen-Wei Qiu*. Synthesis of plant-derived cholesterol from bisnoralcohol. Steroids 2022, 178, 108967.
Dandan Guo, Liming He, Yaoxin Gao, Chenxu Jin, Haizhen Lin, Li Zhang, Liting Wang, Ying Zhou, Jie Yao, Yixin Duan, Renzheng Yang, Wenwei Qiu*, Wenzheng Jiang*. Obeticholic Acid Derivative, T-2054 Suppresses Osteoarthritis via Inhibiting NF-κB-Signaling Pathway. Int. J. Mol. Sci. 2021, 22(8), 3807.
Huang Chen, Aiwu Bian, Lian-Fang Yang, Xuan Yin, Jie Wang, Chaowen Ti, Ying Miao, Shihong Peng, Shifen Xu, Mingyao Liu*, Wen-Wei Qiu*, Zhengfang Yi*. Targeting STAT3 by a small molecule suppresses pancreatic cancer progression. Oncogene 2021, 40(8), 1440-1457.
Shihong Peng, Jie Wang, Huang Chen, Pan Hu, Xiao-Long He, Yundong He, Minna Wang, Wenshu Tang, Qiurui He, Ying-Ying Wang, Jiayi Xie, Dandan Guo, Shancheng Ren, Mingyao Liu, Wen-Wei Qiu*, Zhengfang Yi*. Regression of castration-resistant prostate cancer by a novel compound QW07 targeting androgen receptor N-terminal domain. Cell Biol. Toxicol.2020, 36(5), 399-416.
Jie Wang, Xiang-Zhong Gu, Li-Ming He, Chen-Chen Li, Wen-Wei Qiu*. Synthesis of ursodeoxycholic acid from plant-source (20S)-21-hydroxy-20-methylpregn-4-en-3-one. Steroids 2020, 157, 108600.
Jinhua Wang, Yajing Xing, Yingying Wang, Yundong He, Liting Wang, Shihong Peng, Lianfang Yang, Jiuqing Xie, Xiaotao Li, Wen-Wei Qiu*, Zhengfang Yi1* and Mingyao Liu*. A novel BMI-1 inhibitor QW24 for the treatment of stem-likecolorectalcancer. J. Exp. Clin. Cancer Res. 2019, 38, 422.
Huiqing Chen, Yajing Xing, Jia Xie, Jiuqing Xie, Dong Xing, Jie Tang, Fan Yang, Zhengfang Yi* and Wen-Wei Qiu*. Synthesis and biological evaluation of 3-nitro-4-chromanone derivatives as potential antiproliferative agents for castration-resistant prostate cancer. RSC Advances 2019, 9, 33794–33799.
Zhen Chen, TuoShao, Wei Gao, Hualong Fu, ThomasLee Collier, Jian Rong, Xiaoyun Deng, Qingzhen Yu, Xiaofei Zhang, April T. Davenport, James B. Daunais, Hsiao-Ying Wey, Yihan Shao, Lee Josephson, Wen-Wei Qiu*, and StevenLiang*. Synthesis and Preliminary Evaluation of [11C]GNE-1023 as a Potent PET Probe for Imaging Leucine-Rich Repeat Kinase 2(LRRK2) in Parkinson’s Disease. ChemMedChem 2019, 14, 1580-1585.
Jie Bai, Jia Xie, Yajing Xing, Li-Ting Wang, Jiuqing Xie, Fan Yang, Ting Liu, MingyaoLiu, Jie Tang, Zhengfang Yi, Wen-Wei Qiu*, Synthesis and biological evaluation of methylpyrimidine-fused tricyclic diterpene analogs as novel oralanti-late-onset hypogonadism agents, Eur. J. Med. Chem. 2019, 176, 21-40.
Jie Bai, Jia Xie, Li-Ting Wang, Yajing Xing, Qian-Ru Jiang, Fan Yang, Jie Tang, Zhengfang Yi*, Wen-Wei Qiu*. Discoveryof methylpyrimidine ring-fused diterpenoid analogs as a novel testosterone synthesis promoter. RSC Advances 2019, 9, 9709–9717.
Huiqing Chen, Jia Xie, Dong Xing, Jinping Wang, Jie Tang, Zhengfang Yi, Fei Xia, Wen-Wei Qiu*, Fan Yang*, Diastereoselective synthesis of 3,3-disubstituted-3-nitro-4-chromanone derivatives as potential antitumor agents. Org. Biomol. Chem. 2019, 17, 1062-1066.
Shi-You Jiang, Hui Li, Jing-Jie Tang, Jie Wang,Jie Luo, Bing Liu, Jin-Kai Wang, Xiong-Jie Shi,Hai-Wei Cui, Jie Tang, Fan Yang,Wei Qi, Wen-Wei Qiu*, Bao-Liang Song*. Discovery of a potent HMG-CoA reductase degrader that eliminatesstatin-induced reductase accumulation and lowers cholesterol. Nat. Commun. 2018, 9, 5138.
Xiao-Long He, Li-Ting Wang, Xiang-Zhong Gu,Jie-Xin Xiao, Wen-Wei Qiu*. A facilesynthesis of ursodeoxycholic acid and obeticholic acid from cholic Acid, Steroids 2018, 140, 173-178.
Lian-Fang Yang, Yajing Xing, Jie-Xin Xiao, JiaXie, Wei Gao, Jiuqing Xie, Li-Ting Wang, Jinhua Wang, Mingyao Liu, Zhengfang Yi*, Wen-WeiQiu*. Synthesis of Cyanoenone-Modified Diterpenoid Analogs as Novel Bmi-1-MediatedAntitumor Agents. ACS Med. Chem. Lett. 2018, 9, 1105-1110.
Xiao-Long He, Yajing Xing, Xiang-Zhong Gu, Jie-Xin Xiao, Ying-Ying Wang, Zhengfang Yi, Wen-Wei Qiu*. The synthesis and antitumor activity of lithocholic acid and its derivatives. Steroids 2017, 125, 54-60.
Xu Xiao, Jing-Jie Tang, Chao Peng, Yan Wang, Lin Fu, Zhi-Ping Qiu, Yue Xiong, Lian-Fang Yang, Hai-Wei Cui, Xiao-Long He, Lei Yin, Wei Qi, Catherine C.L. Wong, Yun Zhao, Bo-Liang Li, Wen-Wei Qiu*, Bao-Liang Song*. Cholesterol Modification of Smoothened Is Required for Hedgehog Signaling. Mol. Cell 2017, 66, 154-162.
Gao Wei, Yalan Wu, Xiao-Long He, Ting Liu, Mingyao Liu, Jian Luo*, Wen-Wei Qiu*. Synthesis of heterocyclic ring-fused tricyclic diterpene analogs as novel inhibitors of RANKL-induced osteoclastogenesis and bone resorption. Eur. J. Med. Chem. 2017, 131, 48-67.
Ying-Ying Wang, Yuan He, Lian-Fang Yang, Shi-Hong Peng, Xiao-Long He,Jin-Hua Wang, Fang Lv, Yun Hao, Ming-Yao Liu, Zhengfang Yi*, Wen-Wei Qiu*. Synthesis of novel diterpenoidanalogs with in-vivo antitumoractivity. Eur. J. Med. Chem. 2016, 120, 13-25.
Hai-Wei Cui, Shihong Peng, Xiang-Zhong Gu, Huang Chen, Yuan He, Wei Gao , Fang Lv,Jin-Hua Wang, Yan Wang, Jia Xie, Ming- Yao Liu, Zhengfang Yi*, Wen-Wei Qiu*. Synthesisand biological evaluation of D-ring fused 1,2,3-thiadiazole dehydroepiandrosteronederivatives as antitumor agents. Eur. J. Med. Chem. 2016, 111, 126-137.
Ying-Ying Wang, Yuan-Xue Gao, Wei Gao, Yuan Xu, Ya-Zhou Xu, Yun-Jie Wang, Sai Chang, Li-Gang Yu, Lu-Yong Zhang, Hong Liao, Lian-Fang Yang, Tao Pang*, Wen-Wei Qiu*. Design, synthesis and biological evaluation of tricyclic diterpene derivatives as novel neuroprotective agents against ischemic brain injury. Eur. J. Med. Chem. 2015, 103, 396-408.
Hai-Wei Cui, Yuan He, Jinhua Wang, Wei Gao, Ting Liu, Min Qin, Xue Wang, Cheng Gao, Yan Wang, Ming-Yao Liu, Zhengfang Yi *, Wen-Wei Qiu*. Synthesis of heterocycle-modified betulinic acid derivatives as antitumor agents. Eur. J. Med. Chem. 2015, 95, 240-248.
Li-Gang Yu, Teng-Feng Ni, Wei Gao, Yuan He, Ying-Ying Wang, Hai-Wei Cui, Cai-Guang Yang, Wen-Wei Qiu*. The synthesis and antibacterial activity of pyrazole-fused tricyclic diterpene derivatives. Eur. J. Med. Chem. 2015, 90, 10-20.
Gao Cheng, Dai Fu-Jun, Cui Hai-Wei, Peng Shi-Hong, He Yuan, Wang Xue, Yi Zheng-Fang*, Qiu Wen-Wei*. Synthesis of Novel Heterocyclic Ring-Fused 18β-Glycyrrhetinic Acid Derivatives with Antitumor and Antimetastatic Activity. Chem. Biol. Drug. Des.2014, 84, 223-233.
Jun Xu, Zhenxi Li, Jian Luo, Fan Yang, Ting Liu, Mingyao Liu,* Wen-Wei Qiu,* and Jie Tang*. Synthesis and Biological Evaluation of Heterocyclic Ring-fused Betulinic Acid Derivatives as Novel Inhibitors of Osteoclast Differentiation and Bone Resorption. J. Med. Chem. 2012, 55, 3122-3134. (Highlighted by "SicBX")
Hui Li, Hui Zou, Lixin Gao, Ting Liu, Fan Yang, Jingya Li, Jia Li,* Wen-Wei Qiu,* and Jie Tang. Synthesis and Biological Evaluation of Oleanolic Acid Derivatives as Novel Inhibitors of Protein Tyrosine Phosphatase 1B. Heterocycles2012, 85, 1117-1139.
Hui Li, Jin-Ping Wang, Fan Yang, Ting Liu, Wen-Wei Qiu, Jing-Ya Li, Jia Li,* Jie Tang. Design, synthesis and biological activity evaluation of 2-mercapto-4(3H)-quinazolinone derivatives as novel inhibitors of protein tyrosine phosphatase 1 B. Heterocycles2012, 85, 1897-1911.
Wu X, Li Z, Yang Z, Zheng C, Chen Y, Ye X, Lian X, Qiu Wen-Wei, Yang F, Tang J, Xiao J, Liu M, Luo J. CADPE suppresses RANKL-induced osteoclastogenesis and prevents ovariectomy-induced bone loss through inhibition of MAPKs/AP-1 and Ca2+-NFAT signaling pathways. J. Bone Miner. Res. 2012, 27, 1298-1308.
Jing-jie Tang, Jia-gui Li, Wei Qi, Wen-wei Qiu, Pei-shan Li, Bo-liang Li, and Bao-Liang Song. Inhibition of SREBP by a small molecule, betulin, improves hyperlipidemia and insulin resistance and reduces atherosclerotic plaques. Cell Metab. 2011, 13, 44-56.
Wen-wei Qiu, Karavadhi Surendra, Liang Yin, and E. J. Corey, Selective formation of six-membered oxa- and carbocycles by the In(III)-activated ring closure of acetylenic substrates. Org. Lett. 2011, 13, 5893-5895.
Karavadhi Surendra, Wen-wei Qiu, and E. J. Corey. A powerful new construction of complex chiral polycycles by an indium(III)-catalyzed cationic cascade. J. Am. Chem. Soc. 2011, 133, 9724-9726.
Chun Li, Wen-wei Qiu, Zhengfeng Yang, Jian Luo, Fan Yang*, Ming-yao Liu, Juan Xie and Jie Tang*. Steroslective synthesis of some methyl-substituted steroid hormones and their in vitro cytotoxic activity against human gastric cancer cell line MGC-803. Steroids, 2010, 75, 859-869.
Cheng-hai Li, Zheng-feng Yang, Zhen-xi Li, Yu Ma, Li-peng Zhang, Chun-bing Zheng, Wen-wei Qiu, Xian Wu, Xiu Wang, Hui Li, Jie Tang, Min Qian, Da-li Li1, Ping Wang, Jian Luo,, Ming-yao Liu. Maslinic acid suppresses osteoclastogenesis and prevents ovariectomy-induced bone loss by regulating RANKL-mediated NF-κB and MAPK signaling pathways. J. Bone. Miner. Res. 2011, 26, 644-656.
Cheng-hai Li, Zheng-feng Yang, Chun-yan Zhai, Wen-wei Qiu, Dali Li, Zheng-fang Yi, Lei Wang, Jie Tang, Min Qian, Jian Luo, and Ming-yao Liu. Maslinic acid potentiates the anti-tumor activity of tumor necrosis factor α by inhibiting NF-κB signaling pathway. Mol. Cancer. 2010, 9(73), 1-13.
Wen-wei Qiu, Qiang Shen, Fan Yang, Bo Wang, Hui Zou, Jing-ya Li, Jia Li*, Jie Tang*. Synthesis and biological evaluation of heterocyclic ring- substituted maslinic acid derivatives as novel inhibitors of protein tyrosine phosphatase 1B. Bioorg. Med. Chem. Lett. 2009, 19, 6618-6622.
Wen-wei Qiu, Linmei He, Qi Chen, Wanrong Luo, Zhichao Yu, Fan Yang*, Jie Tang*. Imidazolium-modified poly(L-leucine) catalyst: an efficient and recoverable catalyst for Juliá–Colonna reactions. Tetrahedron Lett. 2009, 50, 5225-5227.
Wen-wei Qiu, Jie Xu, Xin Li, Li Zhong, Jing-ya Li, Jia Li, Fa-jun Nan. Design and synthesis of matrix metalloprotease photoaffinity trimodular probes. Chin. J. Chem. 2009, 27, 825-833.
Bo Wang, Fan Yang, Yifan Shan, Wen-wei Qiu *, Jie Tang *.Highly efficient synthesis of capsaicin analogues by condensation of vanillylamine and acyl chlorides in a biphase H2O/CHCl3 system. Tetrahedron2009, 65, 5409-5412.
Chun Shen, Wen-wei Qiu* Jie Tang. Enantioselective cyano-ethoxycarbonylation of aldehydes catalyzed by bifunctional salen-Ti complex. Chin. J. Org. Chem. 2009, 29, 426-431.
Yong-hua Gong, Wen-wei Qiu, Fan Yang, Pierre Audebert, Gilles Clavier, Fabien Miomander, Jie Tang*. Pyridinium conjugated ferrocenes with thien and bithien bridges: synthesis and electrochemical properties. Chin. J. Chem.2009,27, 1515-1522.
Xiu-ling Xu, Wen-wei Qiu, Qing Zhou, Pierre Audebert, Jie Tang*, Fan Yang*, Zhen-rong Sun*, Nonlinear Optical Absorption Properties of Two ultisubstituted p-Dimethylaminophenyl- ethenyl Pyridiniums. J. Phy. Chem. B2008, 112, 4913-4917.
Wen-wei Qiu, Jie Xu, Jing-Ya Li, Jia Li, and Fa-Jun Nan. Activity-based protein profiling for type I methionine aminopeptidase by using photo-affinity trimodular probes. ChemBioChem. 2007, 8, 1351-1358.
Fan Yang, Xiu-Ling Xu, Yong-Hua Gong, Wen-Wei Qiu, Zhen-Rong Sun, Jin-Wei Zhou, Pierre Audebert and Jie Tang. Synthesis and nonlinear optical absorption properties of two new conjugated ferrocene-bridge-pyridinium compounds. Tetrahedron2007, 63, 9188-9194.
Wen-wei Qiu, Jie Xu, Da-Zhi Liu, Jing-Ya Li, Yang Ye, Xing-Zu Zhu, Jia Li and Fa-Jun Nan. Design and synthesis of a biotin-tagged photoaffinity probe of paeoniflorin. Bioorg. Med. Chem. Lett. 2006, 16, 3306-3309.
徐军, 王晋萍, 钱辰旭, 仇文卫*, 杨帆, 汤杰. 白桦脂酸的研究进展. 生命科学. 2011, 23, 503-510.
仇文卫, 汤杰. 化学小分子探针在药物发现中的应用. 化学教学. 2009, 9, 1-4.
王博, 仇文卫*, 喻艳华, 杨帆, 汤杰. 山楂酸的研究进展. 生命科学. 2009, 21, 264-269.
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