胡文浩 - 华东师范大学 - 化学与分子工程学院

个人简介

主要学历： 1983-1987 年：四川大学化学系学士学位 1987-1990 年：中国科学院成都有机化学研究所硕士学位 1995-1998 年：香港理工大学应用生物及化学科技学系博士学位科研工作简历和学术任职： 1993-1998 年：中国科学院成都有机化学研究所先后任实习研究员（1990）‚助理研究员（1993）‚ 副研究员（1997）。不对称合成联合开放实验室副主任（1992）‚课题组长（1992）‚其间公派到香港理工大学攻读博士学位； 1998-2001 年：美国亚利桑那大学化学系博士后； 2002-2003 年：美国GeneSoft制药公司‚新药研发‚美国旧金山； 2003-2006 年：美国施贵宝制药公司‚制药工艺研究‚美国新泽西。 2006-至今：华东师范大学化学系教授；上海市高校特聘教授（2009-）；华东师范大学小分子药物研究所所长（2010-）。荣誉及获奖 2010 年教育部自然科学二等奖； 2010 年 Asian Core Program Lectureship Award 2009 年上海市高校“东方学者”特聘教授； 2009 年 “上海市优秀学科带头人”； 2008 年 Thieme Chemistry Journal Award； 2007 年上海市“浦江计划”； 2006 年上海市“曙光学者”； 2005 年 “四川省学术和技术带头人”； 2002 年四川省科学技术进步一等奖； 1994 年四川省科学技术进步二等奖。

研究领域

近年来的研究方向集中在以下几个方面：1）多组分新反应及其在生理活性化合物高效合成中的应用；2）基于结构改造的小分子新药研究‚主要研究针对耐药菌的新型抗生素；3）非专利药的制药工艺研究。

近期论文

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A Rh(II)-catalyzed multicomponent reaction by trapping an a-amino enol intermediate in a traditional two-component reaction pathway. Shunying Liu,Wenfeng Yao, Yuan Liu, Qinghua Wei, Jianghui Chen,Xiang Wu, Fei Xia,* Wenhao Hu* Sci. Adv. 2017, 3, 1602467. A DFT Calculation-inspiring Rh(I)-catalyzed Reaction via Suppression of α-H Shift in α-Alkyldiazoacetates. Shunying Liu, Jun Jiang, Jianghui Chen, Qinghua Wei, Wenfeng Yao, Fei Xia and Wenhao Hu Chem. Sci., 2017, DOI: 10.1039/C7SC00257B Asymmetric Multicomponent Reactions Based on Trapping of Active Intermediates Dan Zhang and Wenhao Hu* Chem. Rec. 2017, 17, 1–16 Deactivating Influence of 3‑O‑Glycosyl Substituent on Anomeric Reactivity of Thiomannoside Observed in Oligomannoside Synthesis. Jun Zhou,† Siying Lv, Dan Zhang, Fei Xia,* and Wenhao Hu* J. Org. Chem. 2017. DOI: 10.1021/acs.joc.6b03017 An efficient stereoselective synthesis of six stereoisomers of 3, 4-diaminocyclohexane carboxamide as key intermediates for the synthesis of factor Xa inhibitors Xin Wang, Mingliang Ma, Alavala Gopi Krishna Reddy, Wenhao Hu* Tetrahedron. 2017, 73,1381-1388 Enantioselective Synthesis of α‑Mercapto-β-amino Esters via Rh(II)/Chiral Phosphoric Acid-Cocatalyzed Three-Component Reaction of Diazo Compounds, Thiols, and Imines Guolan Xiao, Chaoqun Ma, Dong Xing,* and Wenhao Hu* Org. Lett. 2016, 18, 6086−6089 Recent Advances in Asymmetric Metal-Catalyzed Carbene Transfer from Diazo Compounds Toward Molecular Complexity. Nilesh J. Thumar, Qinghua Wei, Wenhao Hu* Advances in Organometallic Chemistry. 2016. DOI:10.1016/bs.adomc.2016.08.002 Diastereoselective Intramolecular Aldol-Type Trapping of Zwitterionic Intermediates by Ketones for the Synthesis of Spiro[chroman-4,3’-oxindole] Derivatives Shikun Jia, Yubing Lei, Longlong Song,A. Gopi Krishna Reddy, Dong Xing ,and Wenhao Hu* Adv. Synth. Catal. 2016, DOI:10.1002/adsc.201600998 Enantioselective trapping of oxonium ylide intermediates by N-benzhydryl-a-imino ester: Synthesis of b-tetrasubstituted a-amino acids Shi-Kun Jia, Yu-Bing Lei, Long-Long Song, Shun-Ying Liu *, Wen-Hao Hu* Chinese Chemical Letters. 2016 dx.doi.org/10.1016/j.cclet.2016.06.053 Rh(II)-catalyzed three-component reaction of 3-diazooxindoles with N,N-disubstituted anilines and glyoxylates for the synthesis of 3-aryl-3-substituted oxindoles. Shi-Kun Jia, Long-Long Song, Yu-Bing Lei, A. Gopi Krishna Reddy, Dong Xing and Wen-Hao Hu* Org. Biomol. Chem., 2016, DOI: 10.1039/C6OB01907B Enantioselective Oxidative Functionalization of Csp3-H Bond Adjacent to Nitrogen Atom for Rapid Access to β- Hydroxyl-α-Amino Acid Derivatives Lin Qiu, Xin Guo, Yu Qian, Changcheng Jing, Chaoqun Ma, Shunying Liu,* and Wenhao Hu * ChemComm .2016, DOI: 10.1039/C6CC04710F New peptide deformylase inhibitors design, synthesis and pharmacokinetic assessment Fengping Lv , Chen Chen , Yang Tang , Jianhai Wei , Tong Zhu, Wenhao Hu* Bioorg. Med. Chem. Lett. 2016, 26, 3714–3718 Pd(II)/β-ICD Co-catalysed Asymmetric Route to Oxindole Scaffold via Cascade Reaction of Diazoacetamides and MBHCarbonates Yang Yang, Chaoqun Ma, Nilesh J. Thumar, Wenhao Hu* J. Org. Chem., Just Accepted Manuscript Double C−H Functionalization of Indoles via Three-Component Reactions/CuCl2‑Catalyzed Aerobic Dehydrogenative Coupling for the Synthesis of Polyfunctional Cyclopenta[b]indoles Liqin Jiang, Weifeng Jin, and Wenhao Hu* ACS Catal. 2016, 6, 6146−6150 Catalyst-Free Halogenation of α‑Diazocarbonyl Compounds with N‑Halosuccinimides: Synthesis of 3‑Halooxindoles or Vinyl Halides Chaoqun Ma, Dong Xing, and Wenhao Hu* Org Lett. 2016，18，3134-3137 A transformation of cyclopropyl carbene: a highly enantioselective three-component reaction via trapping oxonium ylide by imine Mingfeng Li‡ ,Qing Zheng‡ ,Weifeng Jin, Shunying Liu *, Wenhao Hu* (M.L. and Q.Z. equally contributed to the work.‡) Tetrahedron 2016, 72, 2929-2934 Diastereoselective Three-Component Cascade Reaction to Construct Oxindole-Fused Spirotetrahydrofurochroman Scaffolds for Drug Discovery Lin Qiu, Dongwei Wang, Yubing Lei, Lixin Gao, Shunying Liu,* Jia Li, and Wenhao Hu* European Journal of Organic Chemistry DOI:10.102/ejoc.20160315 Metal-Catalyzed Cross-Coupling of Terminal Alkynes with Different Carbene Precursors Jiuwei Che, Dong Xing* and Wenhao Hu* Current Organic Chemistry. 2016, 20, 41-60 An enantioselective three-component reaction of diazoacetates with indoles and enals by iridium/iminium co-catalysis Mingfeng Li‡,XinGuo‡,Weifeng Jin,Qing,Shunying Liu *and Wenhao Hu* (‡ Mingfeng Li and Xin Guo equally contributed to this work.) Chem. Commun..2016, 52, 2736-273 Rh2(OAc)4 and InCl3 co-catalyzed diastereoselective trapping of carbamate ammonium ylides with aldehydes for the synthesis of β-hydroxyl-α-amino acid derivatives Jian-Bei Xi, Ming-Liang Ma, Wenhao Hu* Tetrahedron 2016, 72,579-583