近期论文
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近期论文
Synthesis and biological evaluation of novel quaternary ammonium antibody drug conjugates based on camptothecin derivatives, PLoS ONE, 2023, 18(12): e0292871
Development of HSP90 inhibitors-SN38 conjugates for cancer treatment, Bioorganic Chemistry 137 (2023) 106582
Design and synthesis of multivalent drug delivery system with CA IX inhibitors as ligands, Bioorganic & Medicinal Chemistry 93 (2023) 117456
Design, synthesis, and biological evaluation of BRD4 degraders, Bioorganic & Medicinal Chemistry 78 (2023) 117134
Design, synthesis, and biological evaluation of 4?(1H?1,2,3?triazol?1?yl) benzamides as HSP90 inhibitors, Molecular Diversity (2023) 27:239–248
代表性论文
给药系统
SN38-based albumin-binding prodrug for efficient targeted cancer chemotherapy, Journal of Controlled Release, 2021, 339, 297-306
A camptothecin-based albumin-binding prodrug enhances efficacy and safety in vivo, European Journal of Medicinal Chemistry, 2021, 226, 113851
An HSP90 inhibitor based fluorescent probe for selective tumor targeting, Dyes and Pigments, 2021, 196, 109783
A water-soluble probe with p-hydroxybenzyl quaternary ammonium linker for selective imaging in senescent cells, Analytica Chimica Acta, 2020, 133, 99-108
A Novel Multifunctional 2-Nitroinmidazole-based Bioreductive Linker and its Application in Hypoxia-Activated Prodrug, Bioorganic Chemistry, 2020, 101, 193975
Design, synthesis and biological evaluation of HSP90 inhibitor SN38 conjugates for targeted drug accumulation, Journal of Medicinal Chemistry, 2020, 53, 5421-5441
Optimized HSP90 mediated fluorescent probes for cancer-specific bioimaging, Journal of Materials Chemistry B, 2020, 8, 1878—1896
Enhanced cellular uptake efficiency of DCM probes or SN38 conjugating with phenylboronic acids, Bioorganic & Medicinal Chemistry, 2020, 28, 115377
Synthesis and biological evaluation of paclitaxel and vorinostat co-prodrugs for overcoming drug resistance in cancer therapy in vitro, Bioorganic & Medicinal Chemistry，2019, 27(7), 1405-1413
A series of camptothecin prodrugs exhibit HDAC inhibition activity, Bioorganic & Medicinal Chemistry, 2018, 26, 4706–4715
Synthesis and Biological Evaluation of Paclitaxel and Camptothecin Prodrugs on the Basis of 2-Nitroimidazole, ACS Medicinal Chemistry Letters, 2017, 8 (7), 762–765
Synthesis and biological evaluation of hypoxia-activated prodrugs of SN-38, European Journal of Medicinal Chemisty, 2017, 132, 135-141
Carbamoylmannose enhances the tumor targeting ability of supramolecular nanoparticles formed through host–guest complexation of a pair of homopolymers, Journal of Materials Chemistry B, 2017, 5, 83
10-Boronic acid substituted camptothecin as prodrug of SN-38, European Journal of Medicinal Chemistry, 2016, 116, 84-89
Design, Synthesis, and Biological Evaluation of New Cathepsin B-Sensitive Camptothecin Nanoparticles Equipped with a Novel Multifuctional Linker, Bioconjugate Chemistry, 2016, 27(5), 1267-1275
Synthesis and biological evaluation of bis and monocarbonate prodrugs of 10-hydroxycamptothecins, Bioorganic & Medicinal Chemistry, 2004, 12, 4003-4008
Camptothecin derivative-loaded poly(caprolactone-co-lactide)-b-PEG-b-poly(caprolactone-co-lactide) nanoparticles and their biodistribution in mice, Journal of Controlled Release, 2004, 96, 135-148
药物化学
Design, synthesis, and biological evaluation of Wee1 kinase degraders, European Journal of Medicinal Chemistry, 2022, 243, 114786
Synthesis and fluorescent studies of a low molecular weight rotor for living cancer cell imaging, Dyes and Pigments, 2020, 178,108353
Design, synthesis and biological evaluation of the thioether-containing lenalidomide analogs with anti-proliferative activities, European Journal of Medicinal Chemistry, 2019, 176，419-430
Pyrazolo[4,3-b]pyrimido[4,5-e][1,4]diazepine derivatives as new multi-targeted inhibitors of Aurora A/B and KDR, European Journal of Medicinal Chemistry, 2018, 158, 428-441
Design and synthesis of aryloxypropanolamine as b3-adrenergic receptor antagonist in cancer and lipolysis, European Journal of Medicinal Chemistry, 2018, 150, 757-770
Design, synthesis and biological evaluation of colchicine derivatives as novel tubulin and histone deacetylase dual inhibitors, European Journal of Medicinal Chemistry, 2015, 95, 127-135.
Design, synthesis and biological evaluation of novel homocamptothecin analogues as potent antitumor agents, Bioorganic & Medicinal Chemistry, 2015, 23,1950-1962
Suzuki coupling based synthesis and in vitro cytotoxic evaluation of 7-heteroaryl-substituted camptothecin analogs, Bioorganic & Medicinal Chemistry Letters, 2014, 24, 1597-1599
The discovery and optimization of novel dual inhibitors of topoisomerase ii and histone deacetylase, Bioorganic & Medicinal Chemistry, 2013, 21, 6981-6995
Synthesis and biological evaluation of novel 1,6-diaryl pyridin-2(1H)-one analogs, European Journal of Medicinal Chemistry, 2013, 64, 613-620
The discovery of colchicine-SAHA hybrids as a new class of antitumor agents, Bioorganic & Medicinal Chemistry, 2013, 21, 3240-3244.
Evolution in medicinal chemistry of E-ring-modified Camptothecin analogs as anticancer agents, European Journal of Medicinal Chemistry, 2013, 63, 746-757
Synthesis and biological evaluation of new homocamptothecin analogs, European Journal of Medicinal Chemistry, 2012, 54, 417-422.
Total Synthesis of Camptothecin and SN-38, The Journal of Organic Chemistry, 2012, 77(1), 713-717
Synthesis and Biological Evaluation of Piper Amide Analogues as HDAC Inhibitors, Bioorganic & Medicinal Chemistry Letters,2011, 21, 4844-4866
Design and synthesis of novel benzimidazole derivatives as inhibitors, Bioorganic & Medicinal Chemistry, 2010, 18, 5048-5055.
Chimmitecan, a novel 9-substituted camptothecin, with improved anticancer pharmacologic profiles in vitro and in vivo, Clinic Cancer Research, 2007, 13, 1298-1237.
Identification of 1-isopropylsulfonyl-2-amine benzimidazoles as a new class of inhibitors of hepatitis B virus, European Journal of Medicinal Chemistry, 2007, 42, 1358-1364.
Synthesis and anti-hepatitis B virus activity of novel benzimidazole derivatives, Journal of Medicinal Chemistry, 2006, 49, 4790-4794.
Synthesis and antitumor activity of the hexacyclic camptothecin derivatives, Bioorganic & Medicinal Chemistry Letters,2005, 15, 3233-3236.
Synthesis and antitumor activity of 7-ethyl-9-alkyl derivatives of Camptothecin, Bioorganic & Medicinal Chemistry Letters,2005, 15, 2003-2006.
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