SCHEDULED MAINTENANCE
Fluorinated alcohol mediated N,N′-dialkylation of amino acid derivatives via cascade [1,5]-hydride transfer/cyclization for concise synthesis of tetrahydroquinazoline†
Liang
Wang, 
*ab
Shuai-Shuai
Li
*ab
*ab
Shuai-Shuai
Li
*ab
Abstract
Structurally diverse amino acids and their ester derivatives were conveniently N,N′-dialkylated via a TFE-promoted cascade condensation/[1,5]-hydride transfer/cyclization for straightforward construction of pharmeutically significant tetrahydroquinazolines incorporating various amino acids, which featured broad substrate scope, the use of TFE as a sole solvent, additive-free and mild conditions.
![Graphical abstract: Fluorinated alcohol mediated N,N′-dialkylation of amino acid derivatives via cascade [1,5]-hydride transfer/cyclization for concise synthesis of tetrahydroquinazoline](/en/Image/Get?imageInfo.ImageType=GA&imageInfo.ImageIdentifier.ManuscriptID=C9OB02498K&imageInfo.ImageIdentifier.Year=2020)
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