Issue 8, 2020

Bright carbon nanodots for miRNA diagnostics coupled with concatenated hybridization chain reaction

Abstract

We developed a bright carbon nanodot-based miRNA detection method with signal amplification by concatenated hybridization chain reaction (CHCR). In the presence of target miRNA, CHCR was triggered and a frond-like DNA product was formed, which recovered remarkable fluorescence. The location and level of the target miRNA were then indicated.

Graphical abstract: Bright carbon nanodots for miRNA diagnostics coupled with concatenated hybridization chain reaction

Supplementary files

Article information

Article type
Communication
Submitted
08 Nov 2019
Accepted
02 Jan 2020
First published
02 Jan 2020

Chem. Commun., 2020,56, 1175-1178

Bright carbon nanodots for miRNA diagnostics coupled with concatenated hybridization chain reaction

G. Liu, H. Chai, Y. Tang and P. Miao, Chem. Commun., 2020, 56, 1175 DOI: 10.1039/C9CC08753B

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