The engineering of progressive nanostructures with subtle construction and abundant active sites is a key factor for the advance of highly efficient energy storage devices. Nanostructured metal chalcogenides confined in hollow structures possess abundant electroactive sites, more ions and electron pathways, and high local conductivity, as well as large interior free space in a quasi-closed structure, thus showing promising prospects for boosting energy-related applications. This review focuses on the most recent progress in the creation of diverse confined hollow metal chalcogenides (CHMCs), and their electrochemical applications. Particularly, by highlighting certain typical examples from these studies, a deep understanding of the formation mechanism of confined hollow structures and the decisive role of microstructure engineering in related performances are discussed and analyzed, aiming at prompting the nanoscale engineering and conceptual design of some advanced confined metal chalcogenide nanostructures. This will appeal to not only the chemistry-, energy-, and materials-related fields, but also environmental protection and nanotechnology, thus opening up new opportunities for applications of CHMCs in various fields, such as catalysis, adsorption and separation, and energy conversion and storage.