Issue 9, 2020

NAMI-A preferentially reacts with the Sp1 protein: understanding the anti-metastasis effect of the drug

Abstract

NAMI-A is highly reactive to Sp1, a tumor metastasis related protein, resulting in the perturbation of the protein structure and disruption of the DNA recognition of Sp1. Interestingly, Sp1 is more susceptible than other zinc finger proteins to NAMI-A, suggesting that Sp1 could be the anti-metastasis target of NAMI-A.

Graphical abstract: NAMI-A preferentially reacts with the Sp1 protein: understanding the anti-metastasis effect of the drug

Supplementary files

Article information

Article type
Communication
Submitted
10 Nov 2019
Accepted
24 Dec 2019
First published
24 Dec 2019

Chem. Commun., 2020,56, 1397-1400

NAMI-A preferentially reacts with the Sp1 protein: understanding the anti-metastasis effect of the drug

S. Yuan, S. Chen, H. Wu, H. Jiang, S. Zheng, Q. Zhang and Y. Liu, Chem. Commun., 2020, 56, 1397 DOI: 10.1039/C9CC08775C

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements