Issue 9, 2020
From the journal:

Chemical Communications

Cobaltaelectro-catalyzed oxidative allene annulation by electro-removable hydrazides†

Ruhuai Mei, ORCID logo *ab   Xinyue Fang,b   Liang He,a   Junmei Sun,a   Liang Zou,c   Wenbo Ma ORCID logo b  and  Lutz Ackermann ORCID logo *d  

* Corresponding authors

a College of Pharmacy and Biological Engineering, Chengdu University, Chengdu 610106, P. R. China
E-mail: rmei@cdu.edu.cn

b Antibiotics Research and Re-evaluation Key Laboratory of Sichuan Province, Sichuan Industrial Institute of Antibiotics, Chengdu University, Chengdu 610052, P. R. China

c Affiliated Hospital & Clinical Medical College of Chengdu University, Chengdu 610081, P. R. China

d Institute for Organic and Biomolecular Chemistry, Georg-August-Universität Göttingen, Tammannstr. 2, 37077 Göttingen, Germany
E-mail: Lutz.Ackermann@chemie.uni-goettingen.de

Abstract

An efficient C–H/N–H functionalization with allenes was enabled via versatile electro-oxidative cobalt catalysis. Thus, electrochemical C–H activations were accomplished with high levels of chemoselectivity and regioselectivity in an operationally simple undivided cell setup. The user-friendly nature of this protocol was highlighted by excellent functional group tolerance, an electro-reductive removable hydrazide directing group and easy scalability. Experimental mechanistic studies were indicative of a facile BIES C–H cobaltation event.

Graphical abstract: Cobaltaelectro-catalyzed oxidative allene annulation by electro-removable hydrazides

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Article information

DOI
https://doi.org/10.1039/C9CC09076B
Article type
Communication
Submitted
21 Nov 2019
Accepted
23 Dec 2019
First published
23 Dec 2019

Chem. Commun., 2020,56, 1393-1396

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Cobaltaelectro-catalyzed oxidative allene annulation by electro-removable hydrazides

R. Mei, X. Fang, L. He, J. Sun, L. Zou, W. Ma and L. Ackermann, Chem. Commun., 2020, 56, 1393 DOI: 10.1039/C9CC09076B

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