Issue 10, 2020

Peptide-based short single β-strand mimics without hydrogen bonding or aggregation

Abstract

Generation of short peptides with a single β-strand structure in solution is difficult. Herein, we design a new class of single β-strand peptidic mimics that are stable without self-aggregation in protic and non-protic solvents. Introduction of one present β-strand mimic can induce and propagate the β-strand structure for at least a penta-peptide sequence.

Graphical abstract: Peptide-based short single β-strand mimics without hydrogen bonding or aggregation

Supplementary files

Article information

Article type
Communication
Submitted
26 Oct 2019
Accepted
19 Dec 2019
First published
19 Dec 2019

Chem. Commun., 2020,56, 1573-1576

Peptide-based short single β-strand mimics without hydrogen bonding or aggregation

L. Zhai, Y. Otani, Y. Hori, T. Tomita and T. Ohwada, Chem. Commun., 2020, 56, 1573 DOI: 10.1039/C9CC08378B

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