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A metal-organic zeolitic framework with immobilized urease for use in a tapered optical fiber urea biosensor

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A Correction to this article was published on 29 December 2021

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Abstract

A tapered single-mode coreless single-mode (SCS) structure with high sensitivity for sensing refractive index is described. In order to achieve high specificity of optical biosensors, here enzyme capsulation film was achieved by embedding urease in zeolitic imidazolate framework (ZIF-8/urease) through in situ growth approach on the coreless fibers. Determination of urea is achieved through online monitoring of its binding to the urease in zeolitic imidazolate framework. Refractive index change result in wavelength shifts of the optical fiber biosensor. The resonance wavelength exhibits a good linear relationship with urea concentration in the range of 1 to 10 mM with detection limit of 0.1 mM and sensitivity of 0.8 mM/RIU (refractive index unit) if operated with broadband light ranging from 1525 nm to 1590 nm. Final assessment of optical biosensor in real sample was performed where excellent performance in terms of sensitivity and selectivity was observed.

Schematic representation of experimental setup and mechanism for urea detection. A tapered single-mode coreless single-mode (SCS) structure is placed between a broadband light source ranging (BBS) and optical spectrum analyzer (OSA). ZIF-8/urease composites are applied as a recognition layer for urea detection.

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Acknowledgments

The authors acknowledge financial support from the following sources: National Natural Science Foundation of China Grant (61805016; 61735002); National Key R&D Program of China (2018YFF01012000); Research Fund from Beijing Innovation Center for Future Chips, General Project of Science and Technology Plan of Beijing Education Commission and Key Cultivation Projects of Beijing Information Science and Technology University.

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Authors and Affiliations

  1. School of Instrument Science and Opto-electronics Engineering, Beijing information Science and Technology University, Beijing, 100192, China

    Guixian Zhu, Lin Cheng, Mizhen Zhang, Lianqing Zhu & Mingli Dong

  2. Department of Nanomedicine, Houston Methodist Research Institute, Houston, TX, 77030, USA

    Ruogu Qi

  3. Beijing Innovation Center for Future Chips, Tsinghua University, Beijing, 100084, China

    Jiahao Zhao

  4. School of Instrument and Opto-electronics Engineering, Hefei University of Technology, Anhui, 230009, China

    Lianqing Zhu

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  1. Guixian Zhu
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  2. Lin Cheng
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  4. Mizhen Zhang
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  5. Jiahao Zhao
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  6. Lianqing Zhu
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Correspondence to Guixian Zhu or Mingli Dong.

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Zhu, G., Cheng, L., Qi, R. et al. A metal-organic zeolitic framework with immobilized urease for use in a tapered optical fiber urea biosensor. Microchim Acta 187, 72 (2020). https://doi.org/10.1007/s00604-019-4026-0

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