ORIGINAL ARTICLEIdentification of bioactive anti-angiogenic components targeting tumor endothelial cells in Shenmai injection using multidimensional pharmacokinetics
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Graphical abstract
Shenmai injection (SMI) enhanced the anti-tumor effect of 5FU and normalized tumor vessels. Pharmacokinetic (PK) differences among the various components in SMI resulted in Rd being the most abundant component in tumor endothelial cells (TECs). This study proves that Rd may be an important active form to normalize tumor vessels.
Key words
Shenmai injection
Ginsenoside Rd
Multidimensional pharmacokinetics
Anti-angiogenic
Tumor endothelial cell
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Peer review under the responsibility of Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences.
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These authors made equal contributions to this work.
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