Issue 2, 2020

Palladium-catalyzed oxidative dehydrogenative carbonylation reactions using carbon monoxide and mechanistic overviews

Abstract

Carbon monoxide, which is an abundant and inexpensive carbonyl source, has been widely applied to synthesize carbonyl-containing compounds, for example ketones, esters, and amides. These types of compounds are ubiquitous in natural products, pharmaceuticals, as well as in functional materials. This review focuses on the palladium-catalyzed dehydrogenative C–H/X–H (X = C, N, O) carbonylation transformations under oxidative conditions. The related C–H bonds here include C(sp)–H, C(sp2)–H, and C(sp3)–H bonds. From a step- and atom-economy perspective, transition metal-catalyzed oxidative dehydrogenative C–H/X–H carbonylation reactions with CO constitute one of the most efficient strategies for the construction of versatile carbonyl groups, without the requirement of pre-functionalized substrates.

Graphical abstract: Palladium-catalyzed oxidative dehydrogenative carbonylation reactions using carbon monoxide and mechanistic overviews

Article information

Article type
Tutorial Review
Submitted
28 Aug 2019
First published
18 Dec 2019
This article is Open Access
Creative Commons BY-NC license

Chem. Soc. Rev., 2020,49, 341-353

Palladium-catalyzed oxidative dehydrogenative carbonylation reactions using carbon monoxide and mechanistic overviews

C. Zhu, J. Liu, M. Li and Jan-E. Bäckvall, Chem. Soc. Rev., 2020, 49, 341 DOI: 10.1039/C9CS00397E

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