Issue 1, 2020
From the journal:

Nanoscale Advances

Photo/thermo-responsive and size-switchable nanoparticles for chemo-photothermal therapy against orthotopic breast cancer†

Ying Bi,‡ab   Miao Wang,‡ab   Lirong Peng,‡a   Lifo Ruan,bc   Mengxue Zhou,bc   Yi Hu, ORCID logo *bc   Jun Chen ORCID logo *bc  and  Jimin Gao*a  

* Corresponding authors

a Zhejiang Provincial Key Laboratory for Technology & Application of Model Organisms, School of Laboratory Medicine and Life Science, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China
E-mail: jimingao64@163.com

b CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Multi-disciplinary Research Division, Institute of High Energy Physics, Chinese Academy of Sciences (CAS), Beijing 100049, China
E-mail: chenjun@ihep.ac.cn, huyi@ihep.ac.cn

c University of Chinese Academy of Sciences, Beijing 100049, China

Abstract

Tumor penetration of nanocarriers is still an unresolved challenge for effective drug delivery. Herein, we described a size-switchable nanoplatform in response to an external near-infrared (NIR) laser for transcellular drug delivery. The nanoplatform was constructed with a poly(N-isopropylacrylamide) (PNIPAM)-based nanogel encapsulating chitosan-coated single-walled carbon nanotubes, followed by loading a chemotherapeutic drug, doxorubicin (DOX). In mice bearing orthotopic breast tumors, the photothermal effect from single-walled carbon nanotubes upon NIR irradiation potently inhibited tumor growth. The antitumor effect of the nanomedicine with NIR irradiation might be attributed to its capability of transcellular transport and tumor penetration in mice. In addition, the nanomedicine with NIR irradiation could elicit an antitumor response by increasing cytotoxic T cells and decreasing myeloid-derived suppressor cells. These results validated the application of photo/thermo-responsive nanomedicine in the orthotopic model of breast cancer.

Graphical abstract: Photo/thermo-responsive and size-switchable nanoparticles for chemo-photothermal therapy against orthotopic breast cancer

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Article information

DOI
https://doi.org/10.1039/C9NA00652D
Article type
Communication
Submitted
14 Oct 2019
Accepted
16 Dec 2019
First published
17 Dec 2019
This article is Open Access
Creative Commons BY-NC license

Nanoscale Adv., 2020,2, 210-213

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Photo/thermo-responsive and size-switchable nanoparticles for chemo-photothermal therapy against orthotopic breast cancer

Y. Bi, M. Wang, L. Peng, L. Ruan, M. Zhou, Y. Hu, J. Chen and J. Gao, Nanoscale Adv., 2020, 2, 210 DOI: 10.1039/C9NA00652D

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