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Insight on nano-platinum-catalyzed dehydrogenation of quercetin in presence of peroxide

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Abstract

Quercetin (Qu), a noted polyphenolic flavonol molecule, exhibits remarkable antioxidant properties against bioenzymes like peroxidase and tyrosinase. However, it was found that under pH = 3.5–5.5 and room temperature, Qu cannot reduce hydrogen peroxide (HP) which is a well-perceived reactive oxygen species (ROS) responsible for oxidative stress. We found that in presence of noble-metal nano-particles, such redox interactions can be accomplished. We thus synthesized homogenous PVP-coated nano-platinum particles (PNP) to catalyze the oxidation of Qu by HP. On reaction, Qu is oxidized by HP to ortho-quinone (QQ) following the first-order kinetics. The observed rate constant, ko, gradually increases and tends to saturate with increasing [HP]T where T represents the analytical concentrations of the reactant. The saturation kinetics indicates that the activities of PNP resemble to that of bioenzymes and similarly, the nano-particles host the reactants on its active surface during the redox interactions. The estimated value of the kcat reveals that the extent of catalysis of even 10−10 M PNP is nearly comparable with the rate constants of oxidation of Qu in presence of enzymes like horseradish peroxidase and tyrosinase.

Quercetin (Qu) is a ubiquitous natural antioxidant. However, in acidic buffer media (pH = 3.5–5.5), hydrogen peroxide (HP) cannot oxidize Qu. Strikingly, in presence of nano-platinum particles (PNP), Qu is promptly oxidized by HP to ortho-quinone following the first-order kinetics. PNP hosts the reactants on its active surface during the redox interactions. The saturation kinetics with respect to HP resembles to enzyme-like activities of PNP, and indeed, the calculated value of the rate constant, kcat, is comparable with those of the rate constants of enzyme-mediated oxidation of Qu.

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  1. Department of Chemistry, Ranaghat College, Nadia, West Bengal, 741201, India

    Ranendu Sekhar Das

  2. Department of Chemistry, Visva-Bharati, Santiniketan, 731235, India

    Bula Singh

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Das, R.S., Singh, B. Insight on nano-platinum-catalyzed dehydrogenation of quercetin in presence of peroxide. J Nanopart Res 21, 273 (2019). https://doi.org/10.1007/s11051-019-4712-1

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