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Bioconjugated Plasmonic Nanoparticles for Enhanced Skin Penetration

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Abstract

Plasmonic nanoparticles (NPs) are one of the most promising and studied inorganic nanomaterials for different biomedical applications. Plasmonic NPs have excellent biocompatibility, long-term stability against physical and chemical degradation, relevant optical properties, well-known synthesis methods and tuneable surface functionalities. Herein, we review recently reported bioconjugated plasmonic NPs using different chemical approaches and loading cargoes (such as drugs, genes, and proteins) for enhancement of transdermal delivery across biological tissues. The main aim is to understand the interaction of the complex skin structure with biomimetic plasmonic NPs. This knowledge is not only important in enhancing transdermal delivery of pharmaceutical formulations but also for controlling undesired skin penetration of industrial products, such as cosmetics, sunscreen formulations and any other mass-usage consumable that contains plasmonic NPs.

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Acknowledgements

We apologize to authors whose work could not be included in this review due to space restrictions. Support from the Ministry of Science, Innovation and Universities of Spain is acknowledged through the MANA project CTQ2017-83961-R and JEANS project CTQ2017-92264-EXP. J. J. G.-C. acknowledges the Ministry of Science, Innovation and Universities of Spain for a “Ramon y Cajal” contract (#RyC-2014-14956). M. C. thanks the “Plan Propio de Investigación” from the Universidad de Córdoba (UCO) and the “Programa Operativo de fondos FEDER Andalucía” for its financial support through both postdoctoral contracts (Modality 5.2.A).

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  1. Department of Physical Chemistry and Applied Thermodynamics, Institute of Nanochemistry (IUNAN), University of Córdoba, Campus Universitario de Rabanales, Ed. Marie Curie, 14014, Córdoba, Spain

    David Alba-Molina, Juan J. Giner-Casares & Manuel Cano

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  1. David Alba-Molina
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Correspondence to Juan J. Giner-Casares or Manuel Cano.

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This article is part of the Topical Collection “Surface-modified Nanobiomaterials for Electrochemical and Biomedicine Applications”; edited by “Alain R. Puente-Santiago, Daily Rodríguez-Padrón”.

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Alba-Molina, D., Giner-Casares, J.J. & Cano, M. Bioconjugated Plasmonic Nanoparticles for Enhanced Skin Penetration. Top Curr Chem (Z) 378, 8 (2020). https://doi.org/10.1007/s41061-019-0273-0

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