Histidine-containing dipeptides reduce central obesity and improve glycaemic outcomes: A systematic review and meta-analysis of randomized controlled trials
Kirthi Menon
Monash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia
Search for more papers by this authorClara Marquina
Monash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia
Search for more papers by this authorDanny Liew
Monash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia
Search for more papers by this authorAya Mousa
Monash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia
Search for more papers by this authorCorresponding Author
Barbora de Courten
Monash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia
Correspondence
Barbora de Courten, Monash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine, Monash University, 43-51 Kanooka Grove, Clayton, Melbourne, VIC 3168.
Email: barbora.decourten@monash.edu
Search for more papers by this authorKirthi Menon
Monash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia
Search for more papers by this authorClara Marquina
Monash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia
Search for more papers by this authorDanny Liew
Monash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia
Search for more papers by this authorAya Mousa
Monash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia
Search for more papers by this authorCorresponding Author
Barbora de Courten
Monash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia
Correspondence
Barbora de Courten, Monash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine, Monash University, 43-51 Kanooka Grove, Clayton, Melbourne, VIC 3168.
Email: barbora.decourten@monash.edu
Search for more papers by this authorSummary
Supplementation with histidine-containing dipeptides has been shown to improve obesity and glycaemic outcomes in animal and human studies. We conducted a systematic review and meta-analysis of randomized controlled trials to examine these effects. Electronic databases were searched investigating the effects of histidine-containing dipeptides supplementation on anthropometric and glycaemic outcomes. Meta-analyses were performed using random-effects models to calculate the weighted mean difference and 95% confidence interval. There were 30 studies for the systematic review and 23 studies pooled for meta-analysis. Histidine-containing dipeptide groups had a lower waist circumference (WMD [95% CI] = −3.53 cm [−5.65, −1.41], p = 0.001) and HbA1c level (WMD [95% CI] = −0.76% (8.5 mmol/mol) [−1.29% (14.3 mmol/mol), −0.24% (2.8 mmol/mol)], p = 0.004) at follow-up compared with controls. In sensitivity analyses of studies with low risk of bias, waist circumference, HbA1c, and fasting glucose levels (WMD [95% CI] = −0.63 mmol/L [−1.09, −0.18], p = 0.006) were significantly lower in intervention groups versus controls. There was also a trend toward lower fat mass (p = 0.09), insulin resistance (p = 0.07), and higher insulin secretion (p = 0.06) in intervention versus control groups. Supplementation with histidine-containing dipeptides may reduce central obesity and improve glycaemic outcomes. Further studies exploring histidine-containing dipeptide use in obesity and diabetes prevention and treatment are warranted.
Supporting Information
| Filename | Description |
|---|---|
| OBR_12975_sup-0001-ONLINE SUPPLEMENTAL MATERIAL.pdfPDF document, 1.4 MB |
Table S1– Sample OVID-MEDLINE search strategy Table S2– PICO for study inclusion Table S3–Risk of bias assessment of studies included in a systematic review of the effects of HCDon anthropometric and glycaemic parameters Table S4– GRADE assessment of the effect of HCDs on anthropometric and glycaemic outcomes meta-analyses |
| OBR_12975_sup-0001-ONLINE SUPPLEMENTAL MATERIAL.pdfPDF document, 1.4 MB |
Figure S1– Forest plot showing results of a meta-analysis of the effects of HCDs supplementation on body weight. Data reported as weighted mean differences with 95% CIs. Figure S2– Forest plot showing results of a meta-analysis of the effects of HCDs supplementation on body mass index. Data reported as weighted mean differences with 95% CIs. Figure S3– Forest plot showing results of a meta-analysis of the effects of HCDs supplementation on body fat. Data reported as weighted mean differences with 95% CIs. Figure S4– Forest plot showing results of a meta-analysis of the effects of HCDs supplementation on fat mass. Data reported as weighted mean differences with 95% CIs. Figure S5– Forest plot showing results of a meta-analysis of the effects of HCDs supplementation on fat free mass. Data reported as weighted mean differences with 95% CIs. Figure S6– Forest plot showing results of a meta-analysis of the effects of HCDs supplementation on fasting glucose. Data reported as weighted mean differences with 95% CIs. Figure S7– Forest plot showing results of a meta-analysis of the effects of HCDs supplementation on 2 hour glucose. Data reported as weighted mean differences with 95% CIs. Figure S8– Forest plot showing results of a meta-analysis of the effects of HCDs supplementation on fasting insulin. Data reported as weighted mean differences with 95% CIs. Figure S9– Forest plot showing results of a meta-analysis of the effects of HCDs supplementation on HOMA-IR. Data reported as weighted mean differences with 95% CIs. Figure S10– Forest plot showing results of a meta-analysis of the effects of HCDs supplementation on HOMA-S. Data reported as weighted mean differences with 95% CIs. Figure S11– Forest plot showing results of a meta-analysis of the effects of HCDs supplementation on HOMA-β. Data reported as weighted mean differences with 95% CIs. Figure S12– Funnel plots of all anthropometric outcomes with more than two studies for identification of publication bias Figure S13– Funnel plots of all glycaemic outcomes with more than two studies for identification of publication bias |
Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
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