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Is brain iron trafficking part of the physiology of the amyloid precursor protein?

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Abstract

The amyloid precursor protein is so named, because a proteolytic fragment of it was found associated with a neuropathic disorder now known as Alzheimer’s disease. This fragment, Aβ, along with tau makes up the plaques and tangles that are the hallmark of AD. Iron (and other first-row transition metals) is found associated with these proteinaceous deposits. Much research has focused on the relationship of the plaques and iron to the etiology of the disease. This commentary asks another question, one only more recently addressed namely, what is the physiologic function of the amyloid precursor protein (APP) and of its secretase-generated soluble species? Overall, the data make clear that APP and its products have neurotrophic functions and some data indicate one of these may be to modulate the trafficking of iron in the brain.

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Acknowledgements

The work in the Kosman lab is supported by a grant from the National Institute of Neurological Disorders and Stroke, NS102337. This support is gratefully acknowledged.

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  1. Department of Biochemistry, Jacobs School of Medicine and Biomedical Sciences, The University at Buffalo, Suite 4250, 995 Main St., Buffalo, NY, 14203, USA

    Danielle K. Bailey & Daniel J. Kosman

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Correspondence to Daniel J. Kosman.

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Bailey, D.K., Kosman, D.J. Is brain iron trafficking part of the physiology of the amyloid precursor protein?. J Biol Inorg Chem 24, 1171–1177 (2019). https://doi.org/10.1007/s00775-019-01684-z

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