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Engineered nanostructured materials: benefits and risks

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Abstract

Engineered nanostructured materials have widespread applications in multiple fields ranging from diagnosis to treatment of diseases. These materials are used in bioimaging, drug delivery and beauty care products. The preparation of nanostructured materials does not involve specific methods but different types of materials are synthesized by various strategies to reach a nanoscale dimension, so their range of effect will also vary depending upon the material and strategy involved. In recent years, nanostructured materials and their effect on human health has become a debatable issue. The conclusion is that most nanostructured materials have toxicity issues with one or more cell lines or organisms, though very few are lethal at very low concentration. This review updates the information on a wide range of nanostructured materials and studies showing associated health benefits and risks.

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References

  • Aillon KL, Xie Y, El-Gendy N, Berkland CJ, Forrest ML (2009) Effects of nanomaterial physicochemical properties on in vivo toxicity. Adv Drug Deliv Rev 61(6):457–466

    Article  CAS  Google Scholar 

  • Alarifi S, Ali D, Alkahtani S, Verma A, Ahamed M, Ahmed M, Alhadlaq HA (2013) Induction of oxidative stress, DNA damage, and apoptosis in a malignant human skin melanoma cell line after exposure to zinc oxide nanoparticles. Int J Nanomedicine 8:983–993

    Article  CAS  Google Scholar 

  • Augustus EN, Allen ET, Nimibofa A, Donbebe W (2017) A review of synthesis, characterization and applications of functionalized dendrimers. Am J Polym Sci 7(1):8–14

    CAS  Google Scholar 

  • Barhoumi L, Dewez D (2013) Toxicity of superparamagnetic iron oxide nanoparticles on green alga Chlorella vulgaris. Biomed Res Int 2013:647974. https://doi.org/10.1155/2013/647974

    Article  CAS  Google Scholar 

  • Bera D, Qian L, Tseng TK, Holloway PH (2010) Quantum dots and their multimodal applications: a review. Materials 3(4):2260–2345

    Article  CAS  Google Scholar 

  • Bhatt I, Tripathi BN (2011) Interaction of engineered nanoparticles with various components of the environment and possible strategies for their risk assessment. Chemosphere 82(3):308–317

    Article  CAS  Google Scholar 

  • Daniel MC, Astruc D (2004) Gold nanoparticles: assembly, supramolecular chemistry, quantum-size-related properties, and applications toward biology, catalysis, and nanotechnology. Chem Rev 104(1):293–346

    Article  CAS  Google Scholar 

  • de Lima R, Seabra AB, Durán N (2012) Silver nanoparticles: a brief review of cytotoxicity and genotoxicity of chemically and biogenically synthesized nanoparticles. J Appl Toxicol 32(11):867–879

    Article  CAS  Google Scholar 

  • Doktorovova S, Souto EB, Silva AM (2014) Nanotoxicology applied to solid lipid nanoparticles and nanostructured lipid carriers—a systematic review of in vitro data. Eur J Pharm Biopharm 87(1):1–18

    Article  CAS  Google Scholar 

  • Duclaux L (2002) Review of the doping of carbon nanotubes (multiwalled and single-walled). Carbon 40(10):1751–1764

    Article  CAS  Google Scholar 

  • Dykes GM (2001) Dendrimers: a review of their appeal and applications. J Chem Technol Biotechnol 76(9):903–918

    Article  CAS  Google Scholar 

  • Ekambaram P, Sathali AAH, Priyanka K (2012) Solid lipid nanoparticles: a review. Sci Rev Chem Commun 2(1):80–102

    CAS  Google Scholar 

  • Gajbhiye V, Vijayaraj KP, Kumar TR, Jain N (2007) Pharmaceutical and biomedical potential of PEGylated dendrimers. Curr Pharm Des 13(4):415–429

    Article  CAS  Google Scholar 

  • Gleiter H (2000) Nanostructured materials: basic concepts and microstructure. Acta Mater 48(1):1–29

    Article  CAS  Google Scholar 

  • Gupta AK, Gupta M (2005) Cytotoxicity suppression and cellular uptake enhancement of surface modified magnetic nanoparticles. Biomaterials 26(13):1565–1573

    Article  CAS  Google Scholar 

  • Hardman R (2005) A toxicologic review of quantum dots: toxicity depends on physicochemical and environmental factors. Environ Health Perspect 114(2):165–172

    Article  Google Scholar 

  • Jain K, Kesharwani P, Gupta U, Jain N (2010) Dendrimer toxicity: let's meet the challenge. Int J Pharm 394(1):122–142

    Article  CAS  Google Scholar 

  • Khampieng T, Aramwit P, Supaphol P (2015) Silk sericin loaded alginate nanoparticles: preparation and anti-inflammatory efficacy. Int J Biol Macromol 80:636–643

    Article  CAS  Google Scholar 

  • Kołodziejczak-Radzimska A, Jesionowski T (2014) Zinc oxide—from synthesis to application: a review. Materials 7(4):2833–2881

    Article  CAS  Google Scholar 

  • Lai F, Wissing SA, Müller RH, Fadda AM (2006) Artemisia arborescens L essential oil-loaded solid lipid nanoparticles for potential agricultural application: preparation and characterization. AAPS Pharm Sci Tech 7(1):E10–E18

    Article  Google Scholar 

  • Mahmoudi M, Milani AS, Stroeve P (2010) Synthesis, surface architecture and biological response of superparamagnetic iron oxide nanoparticles for application in drug delivery: a review. Int J Biomed Nanosci Nanotechnol 1(2–4):164–201

    Article  CAS  Google Scholar 

  • Mahmoudi M, Hofmann H, Rothen-Rutishauser B, Petri-Fink A (2011) Assessing the in vitro and in vivo toxicity of superparamagnetic iron oxide nanoparticles. Chem Rev 112(4):2323–2338

    Article  CAS  Google Scholar 

  • Martins M, Azoia NG, Melle-Franco M, Ribeiro A, Cavaco-Paulo A (2017) Permeation of skin with (C60) fullerene dispersions. Eng Life Sci 17(7):732–738

    Article  CAS  Google Scholar 

  • Mironava T, Hadjiargyrou M, Simon M, Rafailovich MH (2014) Gold nanoparticles cellular toxicity and recovery: adipose derived stromal cells. Nanotoxicology 8(2):189–201

    Article  CAS  Google Scholar 

  • Peralta-Videa JR, Zhao L, Lopez-Moreno ML, de la Rosa G, Hong J, Gardea-Torresdey JL (2011) Nanomaterials and the environment: a review for the biennium 2008–2010. J Hazard Mater 186(1):1–15

    Article  CAS  Google Scholar 

  • Prabhu S, Poulose EK (2012) Silver nanoparticles: mechanism of antimicrobial action, synthesis, medical applications, and toxicity effects. Int Nano Lett 2(1):32

    Article  Google Scholar 

  • Prina-Mello A, Crosbie-Staunton K, Salas G, del Puerto Morales M, Volkov Y (2013) Multi parametric toxicity evaluation of SPIONs by high content screening technique: identification of biocompatible multifunctional nanoparticles for nanomedicine. IEEE Trans Magn 49(1):377–382

    Article  Google Scholar 

  • Selim ME, Hendi AA (2012) Gold nanoparticles induce apoptosis in MCF-7 human breast cancer cells. Asian Pac J Cancer Prev 13(4):1617–1620

    Article  Google Scholar 

  • Shi H, Magaye R, Castranova V, Zhao J (2013) Titanium dioxide nanoparticles: a review of current toxicological data. Part Fibre Toxicol 10(1):15

    Article  CAS  Google Scholar 

  • Singh S, Kumar S, Yata VK (2019) Health benefits and potential risks of nanostructured materials. In: Dasgupta N, Ranjan S, Lichtfouse E (eds) Environmental nanotechnology Environmental chemistry for a sustainable world, vol 21. Springer, Cham.

    Google Scholar 

  • Sirelkhatim A, Mahmud S, Seeni A, Kaus NHM, Ann LC, Bakhori SKM, Hasan H, Mohamad D (2015) Review on zinc oxide nanoparticles: antibacterial activity and toxicity mechanism. Nano-Micro Lett 7(3):219–242

    Article  CAS  Google Scholar 

  • Suman T, Rajasree SR, Kirubagaran R (2015) Evaluation of zinc oxide nanoparticles toxicity on marine algae Chlorella vulgaris through flow cytometric, cytotoxicity and oxidative stress analysis. Ecotoxicol Environ Saf 113:23–30

    Article  CAS  Google Scholar 

  • Thostenson ET, Ren Z, Chou TW (2001) Advances in the science and technology of carbon nanotubes and their composites: a review. Compos Sci Technol 61(13):1899–1912

    Article  CAS  Google Scholar 

  • Wang Z, Wang K, Lu X, Li C, Han L, Xie C, Liu Y, Qu S, Zhen G (2015) Nanostructured architectures by assembling polysaccharide-coated BSA nanoparticles for biomedical application. Adv Healthc Mater 4(6):927–937

    Article  CAS  Google Scholar 

  • Weir A, Westerhoff P, Fabricius L, Hristovski K, Von Goetz N (2012) Titanium dioxide nanoparticles in food and personal care products. Environ sci technol 46(4):2242–2250

    Article  CAS  Google Scholar 

  • Yata VK, Ghosh SS (2011) Synthesis and characterization of a novel chitosan based E. coli cytosine deaminase nanocomposite for potential application in prodrug enzyme therapy. Biotechnol Lett. 33(1):153–157

    Article  CAS  Google Scholar 

  • Yiu HHP, Keane MA (2011) Enzyme–magnetic nanoparticle hybrids: new effective catalysts for the production of high value chemicals. J Chem Technol Biotechnol 87(5):583–594

    Article  CAS  Google Scholar 

  • Zhao D, Zhao X, Zu Y, Li J, Zhang Y, Jiang R, Zhang Z (2010) Preparation, characterization, and in vitro targeted delivery of folate-decorated paclitaxel-loaded bovine serum albumin nanoparticles. Int J Nanomed 5:669

    CAS  Google Scholar 

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Correspondence to Vinod Kumar Yata.

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Yata, V.K. Engineered nanostructured materials: benefits and risks. Environ Chem Lett 17, 1523–1527 (2019). https://doi.org/10.1007/s10311-019-00893-x

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