Biochemical reconstitution and genetic characterization of the major oxidative damage base excision DNA repair pathway in Thermococcus kodakarensis
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Abbreviations
BER
base excision repair
8oG
8-oxoguanine
Fpg
formamidopyrimidine DNA glycosylase
Ogg
8-oxoguanine DNA glycosylase
AGOG
archaeal GO glycosylase
AP
apurinic/apyrimidinic
3’-UA
3’-α,β-unsaturated aldehyde
3’-OH
3’-hydroxyl
HhH
helix-hairpin-helix
5’-dRP
5’-deoxyribose-phosphate
Pol B
DNA polymerase B
Pol D
DNA polymerase D
Keywords
Archaea
DNA repair
Base excision repair (BER)
8oxo-guanine (8-oxoG)
Nucleic acid enzymology
Genetics
DNA polymerase
DNA glycosylase
AP endonuclease
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© 2019 The Authors. Published by Elsevier B.V.