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IMMUNOLOGY

Characterizing the BCR repertoire in immune-mediated diseases

Nature Reviews Rheumatology volume 16, pages 7–8 (2020)Cite this article

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B cells can assume protective or pathogenic roles in immune-mediated diseases (IMDs). Analysis of the B cell receptor (BCR) repertoires in six IMDs provides insights into the diversity of B cell repertoires across diseases as well as into potential pathological mechanisms and the effects of different treatments.

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Fig. 1: Model for the role of B cells in immune-mediated diseases.

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Acknowledgements

The authors would like to thank their funding sources, namely, NIH NIAMS R01 AR063676, NIH NIAID U19 AI11049103, and NIH NIAID U01 AI101981 (all awarded to W.H.R.).

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Authors and Affiliations

  1. Division of Immunology and Rheumatology, Department of Medicine, Stanford University, Stanford, CA, USA

    Nitya S. Ramadoss & William H. Robinson

  2. Geriatric Research, Education, and Clinical Center (GRECC), VA Palo Alto Health Care System, Palo Alto, CA, USA

    Nitya S. Ramadoss & William H. Robinson

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  1. Nitya S. Ramadoss
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  2. William H. Robinson
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Correspondence to William H. Robinson.

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The authors declare no competing interests.

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Ramadoss, N.S., Robinson, W.H. Characterizing the BCR repertoire in immune-mediated diseases. Nat Rev Rheumatol 16, 7–8 (2020). https://doi.org/10.1038/s41584-019-0339-y

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