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A mathematical model that combines chemotherapy and oncolytic virotherapy as an alternative treatment against a glioma

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Abstract

In this paper, we propose a mathematical model that combines chemotherapy and oncolytic virotherapy as an alternative to treatment of a glioma. The main idea is to incorporate the virotherapy after the first or second chemotherapy session using a specialist virus that attacks only tumor cells. Some simulations are presented. Based on the results, we conclude that with this combined therapy may reduce the number of chemotherapy sessions and may lead to obtain better results in the fight against gliomas.

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Acknowledgements

This manuscript is an extended version of a paper presented in July 2019 at the XIX International Conference “Computational and Mathematical Methods is Science and Engineering”, in Rota, Spain. One of us (EUC) wishes to thank CONACYT for the financial support granted through scholarship 390634 and to the Universidad de Guadalajara for PROINPEP support.

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Authors and Affiliations

  1. Departamento de Ciencias Exactas y Tecnología, Centro Universitario de los Lagos, Universidad de Guadalajara, Enrique Díaz de León 1144, Colonia Paseos de la Montaña, Lagos de Moreno, Jalisco, Mexico

    E. Urenda-Cázares & A. Gallegos

  2. Departamento de Matemáticas y Física, Universidad Autónoma de Aguascalientes, Avenida Universidad 940, Ciudad Universitaria, 20131, Aguascalientes, Ags., Mexico

    J. E. Macías-Díaz

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  1. E. Urenda-Cázares
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  2. A. Gallegos
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  3. J. E. Macías-Díaz
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Correspondence to E. Urenda-Cázares.

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Urenda-Cázares, E., Gallegos, A. & Macías-Díaz, J.E. A mathematical model that combines chemotherapy and oncolytic virotherapy as an alternative treatment against a glioma. J Math Chem 58, 544–554 (2020). https://doi.org/10.1007/s10910-019-01084-3

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  • DOI: https://doi.org/10.1007/s10910-019-01084-3

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