Original ArticleNon–Small Cell Lung CancerFinal Overall Survival and Other Efficacy and Safety Results From ASCEND-3: Phase II Study of Ceritinib in ALKi-Naive Patients With ALK-Rearranged NSCLC
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Disclosure: Dr. Viraswami-Appanna and Dr. Passos are employees of and own stocks in Novartis. Dr. Chen was an employee of Novartis at the time of analysis and initiation of the manuscript and owned stock in Novartis. Dr. Nishio has received research funding from Novartis, Ono Pharmaceutical, MSD, Chugai Pharmaceutical, BMS, Taiho Pharmaceutical, Eli Lilly, Pfizer, Astellas Pharma, and AZ, and has acted as an advisor and a consultant for MSD, Novartis, Pfizer, BMS, Ono Pharmaceutical, Chugai Pharmaceutical, Eli Lilly, Taiho Pharmaceutical, Astellas, and AZ. Dr. Felip has acted as an advisor and a consultant for AbbVie, AZ, BerGenBio, Blue Print Medicines, BI, BMS, Celgene, Eli Lilly, Guardant Health, Janssen, Medscape, Merck KGaA, MSD, Novartis, Pfizer, Prime Oncology, Roche, Samsung, Takeda, and Touchtime; received research funding from Fundacion Merck Salud and Grant for Oncology Innovation EMD Serono; and has been compensated for a leadership role at Grifols. Dr. Orlov has acted as an advisor and a consultant for BMS, BI, MSD, Novartis, and Roche. Dr. Park has acted as an advisor and a consultant for Amgen, Astellas, AZ, BluePrint Medicines, BI, BMS, Clovis, Eli Lilly, Hanmi, KHK, Loxo, Merck KGaA, MSD, Novartis, Ono Pharmaceutical, and Roche; participated in a speakers’ bureau for AZ and BI; and received research funding from AZ and MSD. Dr. Yu has acted as an advisor and a consultant for AZ, BI, Novartis, GSK, MSD, Ono Pharmaceutical, and Roche. Dr. Tsai has acted as an advisorand a consultant for Novartis, Pfizer, Roche, Eli Lilly, MSD, BMS, and AZ and has received honoraria from Novartis, Pfizer, Roche, Eli Lilly, MSD, BMS, and AZ. Dr. McKeage has acted as an advisor and a consultant for Novartis and Pfizer and has received research funding from Pfizer. Dr. Mok is a current employee at The Chinese University of Hong Kong; has been compensated for a leadership role at AZ PLC and Hutchison Chi-Med; owns stocks of Hutchison Chi-Med and Sanomics; has received honoraria from ACEA Pharma, Alpha Biopharma Co., Amgen, Amoy Diagnostics Co., AZ, Bayer, BI, Blueprint Medicines, BMS, Celgene, CStone Pharmaceuticals, Eli Lilly, Fishawack Facilitate, Hengrui Therapeutics, Ignyta, Incyte Corporation, InMed Medical Communication, IQVIA, Janssen, Loxo Oncology, Merck Serono, MSD, MoreHealth, Novartis, OncoGenex Pharmaceuticals, OrigiMed, PeerVoice, Pfizer, Prime Oncology, Roche and Genentech, Sanofi-Aventis R&D, SFJ Pharmaceutical, Takeda Pharmaceuticals HK, Vertex Pharmaceuticals, and Yuhan Corporation; has acted as an advisor and a consultant for ACEA Pharma, Alpha Biopharma Co., Amgen, Amoy Diagnostics Co., AZ, Bayer, BI, Blueprint Medicines, BMS, Celgene, Cirina, CStone Pharmaceuticals, Eli Lilly, Fishawack Facilitate, geneDecode Co., Hengrui Therapeutics, Ignyta, Incyte Corporation, InMed Medical Communication, IQVIA, Janssen, Loxo Oncology, Merck Serono, MSD, MoreHealth, Novartis, OncoGenex Pharmaceuticals, OrigiMed, PeerVoice, Pfizer, Prime Oncology, Roche and Genentech, Sanofi-Aventis R&D, SFJ Pharmaceutical, Takeda Pharmaceuticals HK, Vertex Pharmaceuticals, and Yuhan Corporation; has participated in a speakers’ bureau for ACEA Pharma, Alpha Biopharma Co., Amgen, Amoy Diagnostics Co., AstraZeneca, BI, BMS, Eli Lilly, InMed Medical Communication, MSD, Novartis, Pfizer, Prime Oncology, Roche and Genentech, Taiho, and Takeda Oncology; and has received research funding from AZ, BMS, Clovis Oncology, MSD, Novartis, Pfizer, Roche, SFJ, and XCovery. Dr. Scagliotti has acted as a consultant for MSD and Eli Lilly and has received honoraria from Eli Lilly, AZ, Roche, and AbbVie. Dr. Spigel has been compensated for a leadership role at the Centennial Medical Center; has acted as an advisor and a consultant for Genentech and Roche, Novartis, Celgene, BMS, AZ, Pfizer, BI, AbbVie, Foundation Medicine, GSK, Lilly, Merck, Moderna Therapeutics, Nektar, Takeda, Amgen, TRM Oncology, Precision Oncology, Evelo Therapeutics, Illumina, and PharmaMar; has received research funding from Genentech and Roche, Novartis, Celgene, BMS, Lilly, AZ, Pfizer, BI, University of Texas Southwestern Medical Center-Simmons Cancer Center, Merck, AbbVie, GSK, G1 Therapeutics, Neon Therapeutics, Takeda, Foundation Medicine, Nektar, Celldex, Clovis Oncology, Daiichi Sankyo, EMD Serono, Acerta Pharma, Oncogenex, Astellas Pharma, Grail, Transgene, Aeglea Biotherapeutics, Tesaro, Ipsen, ARMO BioSciences, Amgen, and Millennium; and has received travel support from AZ, BI, Celgene, Lilly, EMD Serono, BMS, Genentech, Genzyme, Intuitive Surgical, Merck, Pfizer, Purdue Pharma, Spectrum Pharmaceuticals, and Sysmex. Dr. Shaw has served as a compensated consultant or received honoraria from Achilles, ARIAD, Bayer, Blueprint Medicines, Chugai, Daiichi Sankyo, EMD Serono, Foundation Medicine, Genentech/Roche, Guardant, Ignyta, KSQ Therapeutics, Loxo, Natera, Novartis, Pfizer, Servier, Taiho Pharmaceutical, Takeda, and TP Therapeutics; has received research funding from Daiichi Sankyo, Ignyta, Novartis, Pfizer, Roche and Genentech, and TP Therapeutics; and has received travel support from Pfizer and Genentech and Roche. The remaining authors have nothing to disclose.
ClinicalTrials.gov identifier: NCT01685138