Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

BIOCATALYSIS

Identifying an iodinase

Nature Chemistry volume 11, pages 1076–1078 (2019)Cite this article

Subjects

Flavin-dependent halogenases catalyse the regioselective formation of carbon–chlorine and carbon–bromine bonds using oxygen and inorganic halide salts. Now, genome mining has led to the discovery of a previously unknown viral halogenase that catalyses the iodination of arenes, thereby providing a rare biocatalytic tool for the formation of carbon–iodine bonds.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Mining of novel halogenases using a bioinformatics-based approach.

References

  1. Gkotsi, D. S. et al. Nat. Chem. https://doi.org/10.1038/s41557-019-0349-z (2019).

    Article  PubMed  PubMed Central  Google Scholar 

  2. Weichold, V., Milbredt, D. & van Pée, K.-H. Angew. Chem. Int. Ed. 55, 6374–6389 (2016).

    Article  CAS  Google Scholar 

  3. Dong, C. et al. Science 309, 2216–2219 (2005).

    Article  CAS  Google Scholar 

  4. Ismail, M. et al. Adv. Synth. Catal. 361, 2475–2486 (2019).

    Article  CAS  Google Scholar 

  5. Mori, S., Pang, A. H., Chandrika, N. T., Garneau-Tsodikova, S. & Tsodikov, O. V. Nat. Commun. 10, 1–11 (2019).

    Article  Google Scholar 

  6. Payne, J. T., Poor, C. B. & Lewis, J. C. Angew. Chem. Int. Ed. 54, 4226–4230 (2015).

    Article  CAS  Google Scholar 

  7. Latham, J. et al. Nat. Commun. 7, 11873 (2016).

    Article  Google Scholar 

  8. Schnepel, C., Minges, H., Frese, M. & Sewald, N. Angew. Chem. Int. Ed. 55, 14159–14163 (2016).

    Article  CAS  Google Scholar 

  9. Frese, M. & Sewald, N. Angew. Chem. Int. Ed. 54, 298–301 (2015).

    Article  CAS  Google Scholar 

  10. Rudroff, F. et al. Nat. Catal. 1, 12–22 (2018).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. School of Chemistry, The University of Manchester, Manchester Institute of Biotechnology, Manchester, UK

    Christian Schnepel & Nicholas J. Turner

Authors
  1. Christian Schnepel
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Nicholas J. Turner
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Nicholas J. Turner.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Schnepel, C., Turner, N.J. Identifying an iodinase. Nat. Chem. 11, 1076–1078 (2019). https://doi.org/10.1038/s41557-019-0379-6

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41557-019-0379-6

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing