Immunity
Volume 51, Issue 5, 19 November 2019, Pages 786-788
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Metabolite Sensing by Colonic ILC3s: How Far Is Too Ffar2 Go?

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It is poorly understood how group 3 innate lymphoid cells (ILC3s) recognize metabolites produced by the gut microbiota. In this issue of Immunity, Chun et al. show that short-chain fatty acids sensed through the G protein-coupled receptor Ffar2 promote ILC3 function in the colon.

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