Two new xanthones (1 and 2), together with three known xanthones (3–5), were isolated from the whole plants of Comastoma pulmonarium. Their structures were elucidated by spectroscopic methods, including extensive 1D and 2D NMR techniques. Compounds 1 and 2 were also evaluated for their anti-tobacco mosaic virus (anti-TMV) activity. The results showed that compounds 1 and 2 showed high anti-TMV activity with inhibition rates of 42.8% and 52.4%, respectively. These rates are higher than that of positive control.
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H. G. Sun, Y. Niu, Y. S. Chen, B. Song, C. Q. Liu, D. L. Peng, J. G. Chen, and Y. Yang, J. Syst. Evol., 52, 378 (2014).
T. N. He, S. W. Liu, and R. Wu, Flora of China, Vol. 62, Chinese Science Press, Beijing, 1988, p. 307.
B. X. Zhong, L. Tang, J. N. Jiao, L. Yang, and Y. Ma, J. Med. Pharm. Chin. Minorities, 6, 58 (2009).
X. C. Liu, Y. Zhao, Q. Y. Zeng, and P. C. Lin, Trad. Chin. Med., 9, 3760 (2016).
S. F. Fan, B. L. Hu, J. Y. Ding, and H. F. Sun, Acta Bot. Sin., 30, 307 (1988).
M. Zhou, K. Zhou, Y. L. Zhao, N. J. Xiang, T. D. Zhang, C. M. Zhang, Y. D. Wang, W. Dong, B. K. Ji, L. M. Li, J. Lou, G. P. Li, and Q. F. Hu, Heterocycles, 91, 604 (2015).
M. Zhou, K. Zhou, Y. L. Zhao, N. J. Xiang, T. D. Zhang, Y. D. Wang, W. Dong, B. K. Ji, L. M. Li, J. Lou, G. P. Li, and Q. F. Hu, Phytochem. Lett., 11, 245 (2015).
K. S. Masters and S. Brase, Chem. Rev., 112, 3717 (2012).
M. V. Ignatushchenko, R. W. Winter, H. P. Bachinger, D. J. Hinrichs, and M. K. Riscoe, FEBS Lett., 409, 67 (1997).
K. Likhitwitayawuid, T. Phadungcharoen, and J. Krungkrai, Planta Med., 64, 70 (1998).
W. Wang, Y. Liao, X. Huang, C. Tang, and P. Cai, Nat. Prod. Res., 32, 1769 (2018).
S. A. Suzy, H. Mieke, D. Warta, and S. Unang, Res. J. Chem. Environ, 22, 184 (2018).
Y. P. Wu, W. Zhao, Z. Y. Xia, G. H. Kong, X. P. Lu, Q. F. Hu, and X. M. Gao, Phytochem. Lett., 6, 629 (2013).
W. Jiang, D. L. Zhu, M. F. Wang, Q. S. Yang, M. Y. Zuo, L. Zeng, and G. P. Li, Nat. Prod. Res., 30, 1810 (2015).
H. Y. Yang, D. Y. Niu, L. Wang, S. J. Wang, C. M. Zhang, X. M. Gao, G. Du, and Q. F. Hu, J. Asian. Nat. Prod. Res., 17, 319 (2015).
Q. F. Hu, D. Y. Niu, X. L. Li, Y. H. Qin, G. L. Zhao, Z. Y. Yang, X. M. Gao, and Z. Y. Chen, Heterocycles, 87, 1127 (2013).
Y. H. Duan, Y. Dai, G. H. Wang, X. Zhang, H. F. Chen, J. B. Chen, X. S. Yao, and X. K. Zhang, J. Nat. Prod., 73, 1283 (2010).
A. Rhodes, B. Boothroyd, M. P. M. Gonacle, and G. A. Somerfield, Biochem. J., 81, 28 (1961).
R. R. Sun, F. P. Miao, J. Zhang, G. Wang, X. L. Yin, and N. Y. Jia, Magn. Reson. Chem., 51, 65 (2013).
H. H. Xing, N. J. Xiang, L. X. Liu, G. R. Yang, Y. F. Shen, Y. Yang, L. Zhou, H. Y. Ma, M. Zhou, H. Y. Wu, G. P. Li, and Q. F. Hu, Chem. Nat. Compd., 53, 1052 (2017).
Q. F. Hu, B. Zhou, J. M. Huang, X. M. Gao, L. D. Shu, G. Y. Yang, and C. T. Che, J. Nat. Prod., 76, 292 (2013).
M. Zhou, K. Zhou, X. M. Gao, Z. Y. Jiang, J. J. Lv, Z. H. Liu, G. Y. Yang, M. M. Miao, C. T. Che, and Q. F. Hu, Org. Lett., 17, 2638 (2015).
Acknowledgment
This research was supported by the National Natural Science Foundation of China (No. 21562047), the Research Foundation of China Tobacco Company (No. 110201502006), and the Research Foundation of China Tobacco Yunnan Industrial Co., Ltd. (No. 2017JC05).
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Published in Khimiya Prirodnykh Soedinenii, No. 6, November–December, 2019, pp. 896–898.
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Hu, QF., Wang, XL., Zeng, WL. et al. Two New Xanthones from Comastoma pulmonarium and Their Anti-Tobacco Mosaic Virus Activity. Chem Nat Compd 55, 1039–1042 (2019). https://doi.org/10.1007/s10600-019-02888-0
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DOI: https://doi.org/10.1007/s10600-019-02888-0