Cdr1p highlights the role of the non-hydrolytic ATP-binding site in driving drug translocation in asymmetric ABC pumps
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Graphical abstract
Abbreviations
ABC
ATP-binding cassette
ANI
anisomycin
Cdr1p
Candida drug resistance 1 protein
Cdr2p
Candida drug resistance 2 protein
CFTR
cystic fibrosis transmembrane conductance regulator
CHX
cycloheximide
CnH
connecting helix
CpH
coupling helix
CTZ
clotrimazole
DMSO
dimethyl sulfoxide
ECL
extracellular loop
ICL
intracellular loop
ITR
itraconazole
KTZ
ketoconazole
MCZ
miconazole
MDR
multidrug resistance
MRP1
Multidrug Resistance Protein 1
NR
Nile red
NBD
nucleotide-binding domain
NBS
Nucleotide Binding Site
OM
oligomycin
Pdr5p
Pleiotropic drug resistance 5 protein
PBS
phosphate-buffered saline
PM
plasma membrane
PMSF
phenylmethanesulfonyl fluoride
RB
resuspension buffer
R6G
rhodamine 6G
R123
rhodamine 123
TAP
transporter associated with antigen processing
TMD
transmembrane domain
TMH
transmembrane helix
TLCK
p-tosyl-l-lysine chloromethyl ketone
TPCK
tosyl phenylalanyl chloromethyl ketone
TCSPC
time-correlated single photon counting
VOR
voriconazole
WT
wild-type
Keywords
Antifungal drug resistance
Candida albicans
ABC transporter
ABC signature sequence
Non-hydrolytic nucleotide-binding site
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