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New Synthetic Method and Antioxidant Activity of Betulin Diformate and Allobetulin Formate

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Chemistry of Natural Compounds Aims and scope

A simple and effective method for formylation of betulin using formic acid and 3a,6a-diphenylthioglycoluril is reported. The yield of betulin diformate was 87%. Allobetulin formate (95%) was prepared by reacting betulin diformate with trifluoroacetic acid. The structures of betulin diformate and allobetulin formate were confirmed by IR and NMR spectroscopy. The antioxidant activity of the synthesized compounds was studied.

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Acknowledgment

The work was sponsored by the Ministry of Education and Science of the Russian Federation (Grant No. 05-13108). Antioxidant activity was studied in the framework of state task “Nauka” No. 4.5752.2017 and a program for increasing the competency of Tomsk Polytechnic University.

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Authors and Affiliations

  1. National Research Tomsk State University, Chemistry Faculty, 36 Prosp. Lenina, Tomsk, 634050, Russia

    Salah Arrous, Imene Boudebouz & I. Parunov

  2. National Research Tomsk Polytechnic University, Chemistry Faculty, 30 Prosp. Lenina, Tomsk, 634050, Russia

    E. Plotnikov & O. Voronova

Authors
  1. Salah Arrous
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  2. Imene Boudebouz
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  3. I. Parunov
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  4. E. Plotnikov
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  5. O. Voronova
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Correspondence to Salah Arrous.

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Translated from Khimiya Prirodnykh Soedinenii, No. 6, November−December, 2019, pp. 941−944.

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Arrous, S., Boudebouz, I., Parunov, I. et al. New Synthetic Method and Antioxidant Activity of Betulin Diformate and Allobetulin Formate. Chem Nat Compd 55, 1094–1097 (2019). https://doi.org/10.1007/s10600-019-02902-5

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  • DOI: https://doi.org/10.1007/s10600-019-02902-5

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