A new triterpene, pogostem (1), and a new phloroglucinol derivative, pogostemon D (2), were isolated from the aerial parts of Pogostemon auricularius (L.) Hassk. Their structures were determined from a combination of 1D NMR, 2D NMR, and HR-ESI-MS. Furthermore, pogostem (1) inhibited the proliferation of five human cancer cell lines, KB, SW-480, AGS, Hep-G2, and LU-1, with IC50 values ranging from 45.92 ± 5.65 to 65.83 ± 7.05 μg/mL.
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Acknowledgment
The authors received no direct funding for this research. We are grateful to Mr. Anh Tuan Le (Mientrung Inst. for Scientific Research, VAST, Quang Tri, Vietnam) for collecting the plant material and Mr. Luong Vu Dang (Institute of Chemistry, VAST, Hanoi, Vietnam). We thank Renee Mosi, PhD, from Edanz Group (www.edanzediting.com/ac) for editing a draft of this manuscript.
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Published in Khimiya Prirodnykh Soedinenii, No. 5, September–October, 2019, pp. 766–769.
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Ho, D.V., Tran, L.T.T., Le, D.V. et al. A New Triterpene and a New Phloroglucinol Derivative from the Aerial Parts of Pogostemon auricularius. Chem Nat Compd 55, 890–894 (2019). https://doi.org/10.1007/s10600-019-02839-9
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DOI: https://doi.org/10.1007/s10600-019-02839-9