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A New Isochromeno[4,3-b]Chromen-7(5H)-One Derivative and Bioactive Constituents of Filipendula kiraishiensis

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A new isochromeno[4,3-b]chromen-7(5H)-one derivative, 8-hydroxy-3,10-dimethoxyisochromeno [4,3-b]chromen-7(5H)-one (1), has been isolated from the aerial part of Filipendula kiraishiensis, together with seven known compounds. The structure of the new compound 1 was determined through spectroscopic and MS analyses. Among the isolates, luteolin (2), rutin (3), quercetin (4), and isoquercitrin (5) showed potent inhibition with IC50 values of 24.2 ± 1.2, 18.6 ± 1.3, 10.2 ± 0.5, and 12.2 ± 1.0 μM, respectively, against LPS-induced NO generation. In addition, 8-hydroxy-3,10-dimethoxyisochromeno[4,3-b]chromen-7(5H)-one (1) exhibited anti-Dengue virus activities with IC50 value of 22.4 ± 1.6 μM against Dengue virus serotype 2 strain PL046.

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Acknowledgment

This research was supported by a grant from the Ministry of Science and Technology, Taiwan (MOST 106-2320-B-010-033-MY3), awarded to Prof. J.-J. Chen. This work was also supported by grants from Zuoying Branch of Kaohsiung Armed Forces General Hospital (ZBH 107-26 and ZBH 107-27). Chih-Wun Fang, Li-Chai Chen, Hui-Chu Huang, and Tsung-Hsien Chang have contributed equally in this manuscript.

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Authors and Affiliations

  1. Division of Pharmacy, Zuoying Branch of Kaohsiung Armed Forces General Hospital, 813, Kaohsiung, Taiwan

    Chih-Wun Fang

  2. Department of Pharmacy, Tajen University, 907, Pingtung, Taiwan

    Li-Chai Chen

  3. Department of Respiratory Care, Zuoying Branch of Kaohsiung Armed Forces General Hospital, 813, Kaohsiung, Taiwan

    Hui-Chu Huang

  4. Department of Medical Education and Research, Kaohsiung Veterans General Hospital, 813, Kaohsiung, Taiwan

    Tsung-Hsien Chang

  5. Department of Biological Sciences, National Sun Yat-Sen University, 804, Kaohsiung, Taiwan

    Chun-Lin Chen

  6. Bioresource Collection and Research Center (BCRC), Food Industry Research and Development Institute (FIRDI), 300, Hsinchu, Taiwan

    Ming-Jen Cheng

  7. Faculty of Pharmacy, School of Pharmaceutical Sciences, National Yang-Ming University, 112, Taipei, Taiwan

    Jih-Jung Chen

  8. Department of Medical Research, China Medical University Hospital, 404, Taichung, Taiwan

    Jih-Jung Chen

Authors
  1. Chih-Wun Fang
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  2. Li-Chai Chen
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  3. Hui-Chu Huang
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  4. Tsung-Hsien Chang
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  5. Chun-Lin Chen
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  6. Ming-Jen Cheng
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  7. Jih-Jung Chen
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Corresponding author

Correspondence to Jih-Jung Chen.

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Published in Khimiya Prirodnykh Soedinenii, No. 5, September–October, 2019, pp. 708–710.

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Fang, CW., Chen, LC., Huang, HC. et al. A New Isochromeno[4,3-b]Chromen-7(5H)-One Derivative and Bioactive Constituents of Filipendula kiraishiensis. Chem Nat Compd 55, 821–824 (2019). https://doi.org/10.1007/s10600-019-02823-3

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  • DOI: https://doi.org/10.1007/s10600-019-02823-3

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