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Alcohol-derived acetate modulates brain function

Nature Metabolism volume 1, pages 1036–1037 (2019)Cite this article

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The mechanism of alcohol-induced changes in the brain is multi-faceted. Acetate, the product of hepatic alcohol metabolism, might contribute to addictive behaviour by regulating gene expression.

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Fig. 1: Alcohol affects associative learning via ACSS2-mediated histone acetylation.

References

  1. Mews, P. et al. Nature https://doi.org/10.1038/s41586-019-1700-7 (2019).

    Article  CAS  Google Scholar 

  2. Pandey, S. C., Kyzar, E. J. & Zhang, H. Neuropharmacology 122, 74–84 (2017).

    Article  CAS  Google Scholar 

  3. Schug, Z. T., Vande Voorde, J. & Gottlieb, E. Nat. Rev. Cancer 16, 708–717 (2016).

    Article  CAS  Google Scholar 

  4. Jiang, L. et al. J. Clin. Invest. 123, 1605–1614 (2013).

    Article  CAS  Google Scholar 

  5. Schug, Z. T. et al. Cancer Cell 27, 57–71 (2015).

    Article  CAS  Google Scholar 

  6. Bulusu, V. et al. Cell Rep. 18, 647–658 (2017).

    Article  CAS  Google Scholar 

  7. Kriss, C. L. et al. Alcohol. Clin. Exp. Res. 42, 1909–1923 (2018).

    Article  CAS  Google Scholar 

  8. Huang, Z. et al. Proc. Natl Acad. Sci. USA 115, E9499–E9506 (2018).

  9. Mews, P. et al. Nature 546, 381–386 (2017).

    Article  CAS  Google Scholar 

  10. Cunningham, C. L., Gremel, C. M. & Groblewski, P. A. Nat. Protoc. 1, 1662–1670 (2006).

    Article  CAS  Google Scholar 

  11. Ferbinteanu, J. & McDonald, R. J. Hippocampus 11, 187–200 (2001).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Cell Biology and Cancer Science, The Ruth and Bruce Rappaport Faculty of Medicine, Technion–Israel Institute of Technology, Haifa, Israel

    Alia Ghrayeb, Eyal Gottlieb & Inbal Mor

Authors
  1. Alia Ghrayeb
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  2. Eyal Gottlieb
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  3. Inbal Mor
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Corresponding authors

Correspondence to Eyal Gottlieb or Inbal Mor.

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Competing interests

E.G. is a shareholder and a Director at MetaboMed Ltd. All other authors declare no competing interests.

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Ghrayeb, A., Gottlieb, E. & Mor, I. Alcohol-derived acetate modulates brain function. Nat Metab 1, 1036–1037 (2019). https://doi.org/10.1038/s42255-019-0139-3

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