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New azaphilones from Penicillium variabile, a fungal endophyte from roots of Aconitum vilmorinianum

The Journal of Antibiotics volume 73, pages 77–81 (2020)Cite this article

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Abstract

Two new azaphilone derivatives, comazaphilones G and H (1 and 2), together with eight known analogues (3–10), were isolated from an endophytic fungus Penicillium variabile. Their structures were established on the basis of extensive spectroscopic analysis. Compounds 1, 2 and 4–10 were tested their nitric oxide inhibitory activities in lipopolysaccharide-activated RAW 264.7 macrophage cells. Compounds 1, 2 and 4–9 showed significant nitric oxide inhibitory activities with IC50 values ranged from 4.35 ± 0.05 to 40.52 ± 0.47 μM.

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Acknowledgements

This work was supported by grants from Yunnan Provincial Science and Technology Department-Kunming Medical University Applied Basic Research Joint Special Fund Project [Nos. 2017FE468(-136), 2017FE468(-172)], grants from the National Natural Science Foundation of China (Nos. 31860095, 81860632), a grant from the Scientific Research Foundation of Yunnan Provincial Department of Education (No. 2019J1191), and a grant from the Science and Technology Project of Zunyi City in China (No. ZSKHSZ(2017)05).

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Authors and Affiliations

  1. School of Pharmaceutical Science & Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming, PR China

    Yating Shao, Zhongwen Sun, Huiding Xie, Liudong Song, Kongchun Sun & Wei Li

  2. Institute of Agricultural Environment and Resources, Yunnan Academy of Agricultural Sciences, Beijing Road2238, Kunming, Yunnan, PR China

    Hui Yan

  3. Zhuhai Key Laboratory of Fundamental and Applied Research in Traditional Chinese Medicine, Zhuhai Campus of Zunyi Medical University, Zhuhai, PR China

    Tianpeng Yin

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  1. Yating Shao
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Correspondence to Tianpeng Yin or Wei Li.

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Shao, Y., Yan, H., Yin, T. et al. New azaphilones from Penicillium variabile, a fungal endophyte from roots of Aconitum vilmorinianum. J Antibiot 73, 77–81 (2020). https://doi.org/10.1038/s41429-019-0250-4

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