Issue 12, 2019
From the journal:

MedChemComm

Recent developments on zinc(ii) metal–organic framework nanocarriers for physiological pH-responsive drug delivery

Weicong Liu,†a   Ying Pan,†a   Weiwei Xiao,b   Hongjia Xu,a   Dong Liu,*c   Fei Ren, ORCID logo d   Xinsheng Peng*a  and  Jianqiang Liu ORCID logo *a  

* Corresponding authors

a Guangdong Key Laboratory for Research and Development of Natural Drugs, Dongguan Key Laboratory of Drug Design and Formulation Technology, Key Laboratory of Research and Development of New Medical Materials of Guangdong Medical University and School of Pharmacy, Guangdong Medical University, Dongguan, P. R. China
E-mail: xspeng@gdmu.edu.cn, jianqiangliu8@gdmu.edu.cn
Fax: +86 769 22896560
Tel: +86 769 22896560

b Biosafety Level-3 Laboratory, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou 510515, Guangdong, China

c Shenzhen Huachuang Bio-pharmaceutical Technology Co. Ltd., Shenzhen 518112, China
E-mail: liudong@szhcsk.com

d Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China

Abstract

The high storage capacities and excellent biocompatibilities of zinc(II) metal–organic frameworks (Zn-MOFs) have made them outstanding candidates as drug delivery carriers. Recent studies on the pH-responsive processes based on carrier–drug interactions have proven them to be the most efficient and effective way to control the release profiles of drugs. To satisfy the ever-growing demand in cancer therapy, great efforts are being devoted to the development of methods to precisely control drug release and achieve targeted use of an active substance at the right time and place. In this review article, we discuss the diverse stimuli based on Zn-MOFs carriers that have been achieved upon external activation from single pH-stimulus-responsive or/and multiple pH-stimuli-responsive viewpoints. Also, the perspectives and future challenges in this type of carrier system are discussed.

Graphical abstract: Recent developments on zinc(ii) metal–organic framework nanocarriers for physiological pH-responsive drug delivery

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Article information

DOI
https://doi.org/10.1039/C9MD00400A
Article type
Review Article
Submitted
14 Aug 2019
Accepted
29 Sep 2019
First published
17 Oct 2019

Med. Chem. Commun., 2019,10, 2038-2051

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Recent developments on zinc(II) metal–organic framework nanocarriers for physiological pH-responsive drug delivery

W. Liu, Y. Pan, W. Xiao, H. Xu, D. Liu, F. Ren, X. Peng and J. Liu, Med. Chem. Commun., 2019, 10, 2038 DOI: 10.1039/C9MD00400A

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