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Renal functional markers in extremely premature infants with and without twin–twin transfusion syndrome

Journal of Perinatology volume 40, pages 256–262 (2020)Cite this article

Subjects

Abstract

Objective

Describe renal function of preterm infants <29 weeks of gestational age (GA) with twin–twin transfusion syndrome (TTTS) who received laser therapy.

Design

Retrospective analysis of premature TTTS compared with dichorionic–diamniotic (di–di) twins from 2006 to 2015. Primary outcome was biomarkers of renal injury.

Results

Thirty-three TTTS-laser and 101 di–di newborns with similar GA at birth (26.4 ± 1.4 vs 26.9 ± 1.6 weeks, p = 0.07) were included. Creatinine and urea levels were higher in TTTS-laser group at day of life (DOL) 2–7 (123.5 ± 12.4 vs 75.8 ± 2 μmol/L, p = 0.0001 and 11.9 ± 1.1 mmol/L vs 8.7 ± 0.3 mmol/L, p = 0.0001) and DOL 8–14, (98.1 ± 14.2 vs 64.8 ± 2.3 μmol/L, p = 0.0001 and 9.1 ± 1.2 vs 5.4 ± 0.3 mmol/L, p = 0.0001). There was a significant effect of TTTS status on creatinine level at DOL 8–14.

Conclusion

In extremely preterm with TTTS treated by laser, biomarkers of renal function were higher compared with di–di twins in the first 2 weeks of life.

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Author notes

  1. These authors contributed equally: Anie Lapointe, Gabriel Altit

Authors and Affiliations

  1. Division of Neonatology, Department of Pediatrics, Hôpitaux Universitaires de Genève — Université de Genève, Geneva, Switzerland

    Julie Sommer

  2. Division of Neonatology, Department of Pediatrics, CHU Sainte-Justine—Université de Montréal, 3175, Chemin de la Côte-Sainte-Catherine, Montreal, QC, H3T 1C5, Canada

    Anne-Monique Nuyt, Véronique Dorval & Anie Lapointe

  3. Department of Obstetrics and Gynecology, CHU Sainte-Justine—Université de Montréal, Montreal, QC, Canada

    François Audibert & Sandrine Wavrant

  4. Division of Neonatology, Department of Pediatrics, Montreal Children’s Hospital, McGill University Health Centre, McGill University, 1001 Décarie, B05.2513, Montreal, QC, Canada

    Gabriel Altit

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Sommer, J., Nuyt, AM., Audibert, F. et al. Renal functional markers in extremely premature infants with and without twin–twin transfusion syndrome. J Perinatol 40, 256–262 (2020). https://doi.org/10.1038/s41372-019-0524-5

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